BAX (Protein | Antibody | cDNA Clone | ELISA Kit)

All BAX reagents are produced in house and quality controlled, including 3 BAX Antibody, 16 BAX Gene, 1 BAX qPCR. All BAX reagents are ready to use.

BAX Antibody (3)

BAX cDNA Clone (16)

NM_007527.3

In expression vector

BAX qPCR Primer (1)

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BAX Background

BCL2 associated X (BAX) is traditionally thought to be regulated by anti-apoptotic BCL-2 family members. BCL-2-associated X protein (BAX) is a critical apoptotic regulator that can be transformed from a cytosolic monomer into a lethal mitochondrial oligomer, The pro-apoptotic BCL-2 protein BAX commits human cells to apoptosis by permeabilizing the outer mitochondrial membrane. BAX activation has been suggested to require the separation of helix alpha5 from alpha6 - the 'latch' from the 'core' domain - among other conformational changes. BCL-2-associated X (BAX) protein acts as a gatekeeper in regulating mitochondria-dependent apoptosis. Under cellular stress, BAX becomes activated and transforms into a lethal oligomer that causes mitochondrial outer membrane permeabilization (MOMP).