- EGFR Signaling Pathway
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|Catalog||Size (Price)||Quantity||In Stock||Operation|
BMP and activin membrane-bound inhibitor, homolog (Xenopus laevis) Protein Datasheet
BAMBI / NMA Protein Price Inquiry ( Available Sizes )
BAMBI / NMA Protein Product Information
|Synonym :||BAMBI, Nma|
A DNA sequence encoding the mouse BAMBI (Q9D0L6)(Met1-Ala152) was expressed, fused with the Fc region of human IgG1 at the C-terminus.
|Expression Host:||Human Cells|
BAMBI / NMA Protein QC Testing
|Purity:||> 90% as determined by SDS-PAGE||SDS-PAGE:
BAMBI / NMA protein
|Endotoxin:||< 1.0 EU per μg of the protein as determined by the LAL method|
|Stability:||Samples are stable for up to twelve months from date of receipt at -70℃|
|Predicted N terminal:||Glu 27|
The recombinant mouse BAMBI /Fc is a disulfide-linked homodimer. The reduced monomer comprises 367 amino acids and has a predicted molecular mass of 41 kDa. The apparent molecular mass of the protein is approximately 45 kDa in SDS-PAGE under reducing conditions due to glycosylation.
|Formulation:||Lyophilized from sterile PBS, pH7.4
BAMBI / NMA Protein Usage Guide
|Storage:||Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.|
|Reconstitution:||A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.|
BAMBI / NMA Protein Related Products & Topics
|Molecule||Species||Description //For Detailed Info. and Price------CLICK!||Cat. No|
|BAMBI/NMA||Human||BAMBI/NMA Protein, Recombinant||10890-H08H|
|BAMBI/NMA||Mouse||BAMBI Protein, Recombinant||50895-M02H|
|BAMBI/NMA||Mouse||BAMBI Protein, Recombinant||50895-M08H|
|Molecule||Application||Description //For Detailed Info. and Price------CLICK!||Cat. No|
|WB||BAMBI/NMA Antibody, Mouse MAb||10890-MM04|
|ELISA||BAMBI/NMA Antibody, Mouse MAb||10890-MM06|
|WB, ELISA||BAMBI/NMA Antibody, Rabbit PAb||10890-RP01|
|WB, ELISA||BAMBI/NMA Antibody, Rabbit PAb (Antigen Affinity Purified)||10890-RP02|
|WB, ELISA||BAMBI / NMA Antibody||10890-R211|
BAMBI / NMA Protein Description
BMP and activin membrane-bound inhibitor (BAMBI) is a transmembrane glycoprotein that is a pseudoreceptor of type 1 receptors. BAMBI structurally lacks intracellular serine/threonine kinase domain but with an extracellular domain and a short cytoplasmic region that share sequence similarities with type 1 receptors, whose members have functions in signal transduction in various developing and pathological processes. BAMBI competes with the type 1 receptor, a receptor of the transforming growth factor- beta(TGF- beta) , through functioning as negative regulators of TGF-beta by limiting the signaling range of the TGF-beta family during early embryogenesis. The expression of BAMBI can be induced by accumulated beta- catenin and BMP. The expression level of BAMBI was found aberrantly elevated in most colorectal and hepatocellular carcinomas relative to the corresponding non-cancerous tissues. It suggestes that beta-catenin and TGF-beta interfere growth arrest by inducing the expression of BAMBI, and this may contribute to colorectal and hepatocellular tumorigenesis.
- Sekiya T. et al. 2003, The Journal of Biological Chemistry. 279: 6840-6.
- Shi YG. et al. 2003, Cell. 113 (6): 685-700.
- Wanninger J. et al. 2011, FEBS Lett. 585 (9): 1338-44.