BAMBI / NMA Protein & Antibody

BMP and Activin Membrane-Bound Inhibitor Homolog

BAMBI / NMA Products

BAMBI / NMA Protein, Recombinant

Molecule	Species	Description	Cat. No
BAMBI/NMA	Human	BAMBI/NMA Protein, Recombinant	10890-H08H
BAMBI/NMA	Mouse	BAMBI Protein, Recombinant	50895-M08H

BAMBI / NMA Antibody

Molecule	Application	Description	Cat. No
Human BAMBI/NMA	WB	BAMBI/NMA Antibody, Mouse MAb	10890-MM04
Human BAMBI/NMA	ELISA	BAMBI/NMA Antibody, Mouse MAb	10890-MM06
Human BAMBI/NMA	WB, ELISA	BAMBI/NMA Antibody, Rabbit PAb	10890-RP01
Human BAMBI/NMA	WB, ELISA	BAMBI/NMA Antibody, Rabbit PAb (Antigen Affinity Purified)	10890-RP02

BAMBI / NMA Elisa Pair Set

Molecule	Application	Description	Cat. No
Human BAMBI/NMA	ELISA	BAMBI / NMA Elisa Pair Set	SEK10890

BAMBI / NMA cDNA Clone

Molecule	Species	Description	Cat. No
BAMBI/NMA	Human	Homo sapiens BAMBI/NMA cDNA Clone	HG10890-M
BAMBI/NMA	Mouse	Mouse BAMBI/NMA cDNA Clone / ORF Clone	MG50895-G

BAMBI / NMA Related Areas

Cancer>>Growth Factor & Receptor>>TGF-beta Superfamily>>BMP Family>>BAMBI/NMA

Cancer>>Growth Factor & Receptor>>TGF-beta Superfamily>>TGF-beta Family>>BAMBI/NMA

Immunology>>Cytokine & Receptor>>TGF-beta Superfamily>>TGF-beta Superfamily Modulators>>BAMBI/NMA

BAMBI / NMA Alternative Names

BAMBI, NMA [Homo sapiens]

Bambi, NMA, 2610003H06Rik [Mus musculus]

BAMBI / NMA Background

BMP and activin membrane-bound inhibitor (BAMBI) is a transmembrane glycoprotein that is a pseudoreceptor of type 1 receptors. BAMBI structurally lacks intracellular serine/ threonine kinase domain but with an extracellular domain and a short cytoplasmic region that share sequence similarities with type 1 receptors, whose members have functions in signal transduction in various developing and pathological processes. BAMBI competes with the type 1 receptor, a receptor of the transforming growth factor-beta (TGF-beta), through functioning as negative regulators of TGF-beta by limiting the signaling range of the TGF-beta family during early embryogenesis. The expression of BAMBI can be induced by accumulated beta-catenin and BMP. The expression level of BAMBI was found aberrantly elevated in most colorectal and hepatocellular carcinomas relative to the corresponding non-cancerous tissues. It suggestes that beta-catenin and TGF-beta interfere growth arrest by inducing the expression of BAMBI, and this may contribute to colorectal and hepatocellular tumorigenesis.

BAMBI / NMA Related Studies

1. Sekiya T, et al. (2003) Identification of BMP and Activin Membrane-bound Inhibitor (BAMBI), an Inhibitor of Transforming Growth Factor-β Signaling, as a Target of the β-Catenin Pathway in Colorectal Tumor Cells. The Journal of Biological Chemistry. 279:6840-6. 
2. Shi YG, et al. (2003) Mechanisms of TGF-β Signaling from Cell Membrane to the Nucleus. Cell. 113(6): 685-700.
3. Wanninger J, et al. (2011) Adiponectin induces the transforming growth factor decoy receptor BAMBI in human hepatocytes. FEBS Lett. 585(9):1338-44.