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BAMBI / NMA Antibody, Mouse MAb

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    Human BAMBI/NMA Antibody Product Information
    Immunogen:Recombinant Human BAMBI protein (Catalog#10890-H08H)
    Clone ID:9E3G11A1
    Ig Type:Mouse IgG1
    Concentration:
    Endotoxin:
    Formulation:0.2 μm filtered solution in PBS with 5% trehalose
    Preparation:This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human BAMBI (rh BAMBI; Catalog#10890-H08H; NP_036474.1; Met 1-Ala 152). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
    Other BAMBI/NMA Antibody Products
    Reactivity: Human  
    Application: 
      10890-MM10-50
      10890-MM10-200
      10890-MM10-100
      10890-MM10-1
      50 µg 
      200 µg 
      100 µg 
      1 mg 
      Add to Cart
      Reactivity: Human  
      Application: 
        10890-MM02-50
        10890-MM02-200
        10890-MM02-100
        10890-MM02-1
        50 µg 
        200 µg 
        100 µg 
        1 mg 
        Add to Cart
        Reactivity: Human  
        Application: ELISA  
          10890-RP01-400
          10890-RP01-200
          10890-RP01-100
          400 µg 
          200 µg 
          100 µg 
          Add to Cart
          Reactivity: Human  
          Application: ELISA  
            10890-R211-50
            10890-R211-100
            50 µg 
            100 µg 
            Add to Cart
            Reactivity: Human  
            Application: ELISA  
              10890-MM04-50
              10890-MM04-200
              10890-MM04-100
              50 µg 
              200 µg 
              100 µg 
              Add to Cart
              Reactivity: Human  
              Application: ELISA  WB  
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              10890-RP02-50
              10890-RP02-200
              10890-RP02-100
              50 µg 
              200 µg 
              100 µg 
              Add to Cart
              Reactivity: Human  
              Application: ELISA  
                10890-T16-50
                10890-T16-200
                10890-T16-100
                50 µg 
                200 µg 
                100 µg 
                Add to Cart
                Reactivity: Mouse  
                Application: ELISA  
                  50895-T16-50
                  50895-T16-200
                  50895-T16-100
                  50 µg 
                  200 µg 
                  100 µg 
                  Add to Cart
                  Immunochemical staining of human CCNF in human brain with rabbit polyclonal antibody (1 µg/mL, formalin-fixed paraffin embedded sections).
                  BAMBI/NMA Background

                  BMP and activin membrane-bound inhibitor (BAMBI) is a transmembrane glycoprotein that is a pseudoreceptor of type 1 receptors. BAMBI structurally lacks intracellular serine/ threonine kinase domain but with an extracellular domain and a short cytoplasmic region that share sequence similarities with type 1 receptors, whose members have functions in signal transduction in various developing and pathological processes. BAMBI competes with the type 1 receptor, a receptor of the transforming growth factor-beta (TGF-beta), through functioning as negative regulators of TGF-beta by limiting the signaling range of the TGF-beta family during early embryogenesis. The expression of BAMBI can be induced by accumulated beta-catenin and BMP. The expression level of BAMBI was found aberrantly elevated in most colorectal and hepatocellular carcinomas relative to the corresponding non-cancerous tissues. It suggestes that beta-catenin and TGF-beta interfere growth arrest by inducing the expression of BAMBI, and this may contribute to colorectal and hepatocellular tumorigenesis.

                  Human BAMBI/NMA References
                • Sekiya T, et al. (2003) Identification of BMP and Activin Membrane-bound Inhibitor (BAMBI), an Inhibitor of Transforming Growth Factor- Signaling, as a Target of the -Catenin Pathway in Colorectal Tumor Cells. The Journal of Biological Chemistry. 279:6840-6.
                • Shi YG, et al. (2003) Mechanisms of TGF- Signaling from Cell Membrane to the Nucleus. Cell. 113(6): 685-700.
                • Wanninger J, et al. (2011) Adiponectin induces the transforming growth factor decoy receptor BAMBI in human hepatocytes. FEBS Lett. 585(9):1338-44.
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                  Catalog: 10890-MM06-50
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                  Datasheet & Documentation

                  All information of our products is subject to change without notice. Please refer to COA enclosed in shipped package for the newest information.
                  Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"