Anti-BAMBI Antibody

Cat: 10890-MM06
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Anti-BAMBI Antibody (Mouse Monoclonal antibody) General Information
Product name
Anti-BAMBI Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Human
Specificity
Human BAMBI
Immunogen
Recombinant Human BAMBI protein (Catalog#10890-H08H)
Preparation
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human BAMBI (rh BAMBI; Catalog#10890-H08H; NP_036474.1; Met 1-Ala 152). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
Source
Monoclonal Mouse IgG1 Clone #9E3G11A1
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-BAMBI Antibody (Mouse Monoclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:1000-1:2000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-BAMBI Antibody Alternative Names
Anti-NMA Antibody
BAMBI Background Information

BMP and activin membrane-bound inhibitor (BAMBI) is a transmembrane glycoprotein that is a pseudoreceptor of type 1 receptors. BAMBI structurally lacks intracellular serine/ threonine kinase domain but with an extracellular domain and a short cytoplasmic region that share sequence similarities with type 1 receptors, whose members have functions in signal transduction in various developing and pathological processes. BAMBI competes with the type 1 receptor, a receptor of the transforming growth factor-beta (TGF-beta), through functioning as negative regulators of TGF-beta by limiting the signaling range of the TGF-beta family during early embryogenesis. The expression of BAMBI can be induced by accumulated beta-catenin and BMP. The expression level of BAMBI was found aberrantly elevated in most colorectal and hepatocellular carcinomas relative to the corresponding non-cancerous tissues. It suggestes that beta-catenin and TGF-beta interfere growth arrest by inducing the expression of BAMBI, and this may contribute to colorectal and hepatocellular tumorigenesis.

Full Name
BMP and activin membrane-bound inhibitor
References
  • Sekiya T, et al. (2003) Identification of BMP and Activin Membrane-bound Inhibitor (BAMBI), an Inhibitor of Transforming Growth Factor- Signaling, as a Target of the -Catenin Pathway in Colorectal Tumor Cells. The Journal of Biological Chemistry. 279:6840-6.
  • Shi YG, et al. (2003) Mechanisms of TGF- Signaling from Cell Membrane to the Nucleus. Cell. 113(6): 685-700.
  • Wanninger J, et al. (2011) Adiponectin induces the transforming growth factor decoy receptor BAMBI in human hepatocytes. FEBS Lett. 585(9):1338-44.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-BAMBI Antibody Rabbit Polyclonal ELISA 50895-T16
    Anti-BAMBI Antibody Mouse Monoclonal ELISA 10890-MM04
    Anti-BAMBI Antibody Mouse Monoclonal ELISA(Cap) 10890-MM10
    Anti-BAMBI Antibody Rabbit Monoclonal ELISA 10890-R211
    Anti-BAMBI Antibody Rabbit Polyclonal WB,ELISA 10890-RP02
    Anti-BAMBI Antibody Rabbit Polyclonal ELISA 10890-T16
    Anti-BAMBI Antibody Mouse Monoclonal ELISA(Det) 10890-MM02
    Anti-BAMBI Antibody Rabbit Polyclonal ELISA 10890-RP01
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