BAFFR / TNFRSF13C Protein (CD268 Protein)
B cell-activating factor receptor / Tumor necrosis factor receptor superfamily, member 13C (Cluster of Differentiation 268)
BAFFR / TNFRSF13C Products
BAFFR / TNFRSF13C Protein, Recombinant
BAFFR / TNFRSF13C cDNA Clone
BAFFR / TNFRSF13C Related Areas
Immunology>>Cytokine & Receptor>>TNF Superfamily>>BAFFR/TNFRSF13C
Immunology>>Adaptive Immunity>>Costimulation & Costimulatory Molecule>>BAFFR/TNFRSF13C
Immunology>>Cluster of Differentiation>>B Cell CD Antigen>>BAFFR/TNFRSF13C/CD268
BAFFR / TNFRSF13C Alternative Names
BAFFR, TNFRSF13C, CTA-250D10.7, BAFF-R, CD268, CVID4, MGC138235 [Homo sapiens]
Baffr, Tnfrsf13c, 2010006P15Rik, BAFF-R, Bcmd, Bcmd-1, Bcmd1, Lvis22, MGC123890, MGC123891 [Mus musculus]
BAFFR / TNFRSF13C Background
Tumor necrosis factor receptor superfamily, member 13C (TNFRSF13C) also known as B-cell-activating factor receptor (BAFFR) and CD268 antigen, is a member of the tumor necrosis factor receptor superfamily. A tumor necrosis factor receptor (TNFR), or death receptor, is a trimeric cytokine receptor that binds tumor necrosis factors (TNF). The receptor cooperates with an adaptor protein which is important in determining the outcome of the response. Members of the TNF receptor superfamily (TNFRSF) have crucial roles in both innate and adaptive immunity and in cellular apoptosis process. Apoptosis is a cell suicide mechanism that enables metazoans to control cell number in tissues and to eliminate individual cells that threaten the animal's survival. Certain cells have unique sensors, termed death receptors or tumour necrosis factor (TNFR), on their surface. Tumour necrosis factors (TNFR) detect the presence of extracellular death signals and, in response, they rapidly ignite the cell's intrinsic apoptosis machinery. It has been proposed that abnormally high levels of BAFFR/TNFRSF13C (CD268) may contribute to the pathogenesis of autoimmune diseases by enhancing the survival of autoreactive B cells.
BAFFR / TNFRSF13C Related Studies
- Ashkenazi A, et al. (1998) Death receptors: signaling and modulation. Science. 281(5381): 1305-8.
- Losi CG, et al. (2005) Mutational analysis of human BAFF receptor TNFRSF13C (BAFF-R) in patients with common variable immunodeficiency. J Clin Immunol. 25(5): 496-502.
- Hentges KE, et al. (2002) Tnfrsf13c (Baffr) is mis-expressed in tumors with murine leukemia virus insertions at Lvis22. Genomics. 80(2): 204-12.
TNF Superfamily Ligands
TNF Receptor Superfamily