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BAFFR / TNFRSF13C Protein (CD268 Protein)

B cell-activating factor receptor / Tumor necrosis factor receptor superfamily, member 13C (Cluster of Differentiation 268)

BAFFR / TNFRSF13C Products

BAFFR / TNFRSF13C Protein, Recombinant

Molecule Species Description //For Detailed Info. and Price------CLICK! Cat. No
BAFFR/TNFRSF13C Mouse BAFFR/TNFRSF13C Protein, Recombinant 50353-M02H

BAFFR / TNFRSF13C cDNA Clone

Molecule Species Description //For Detailed Info. and Price------CLICK! Cat. No
BAFFR/TNFRSF13C Mouse Mouse BAFFR/TNFRSF13C cDNA Clone / ORF Clone MG50353-M
BAFFR/TNFRSF13C Rat Rat BAFFR/TNFRSF13C cDNA Clone / ORF Clone RG80171-G

BAFFR / TNFRSF13C Related Areas

Immunology>>Cytokine & Receptor>>TNF Superfamily>>BAFFR/TNFRSF13C

Immunology>>Adaptive Immunity>>Costimulation & Costimulatory Molecule>>BAFFR/TNFRSF13C

Immunology>>Cluster of Differentiation>>B Cell CD Antigen>>BAFFR/TNFRSF13C/CD268

BAFFR / TNFRSF13C Alternative Names

BAFFR, TNFRSF13C, CTA-250D10.7, BAFF-R, CD268, CVID4, MGC138235 [Homo sapiens]

Baffr, Tnfrsf13c, 2010006P15Rik, BAFF-R, Bcmd, Bcmd-1, Bcmd1, Lvis22, MGC123890, MGC123891 [Mus musculus]

BAFFR / TNFRSF13C Background

Tumor necrosis factor receptor superfamily, member 13C (TNFRSF13C) also known as B-cell-activating factor receptor (BAFFR) and CD268 antigen, is a member of the tumor necrosis factor receptor superfamily. A tumor necrosis factor receptor (TNFR), or death receptor, is a trimeric cytokine receptor that binds tumor necrosis factors (TNF). The receptor cooperates with an adaptor protein which is important in determining the outcome of the response. Members of the TNF receptor superfamily (TNFRSF) have crucial roles in both innate and adaptive immunity and in cellular apoptosis process. Apoptosis is a cell suicide mechanism that enables metazoans to control cell number in tissues and to eliminate individual cells that threaten the animal's survival. Certain cells have unique sensors, termed death receptors or tumour necrosis factor (TNFR), on their surface. Tumour necrosis factors (TNFR) detect the presence of extracellular death signals and, in response, they rapidly ignite the cell's intrinsic apoptosis machinery. It has been proposed that abnormally high levels of BAFFR/TNFRSF13C (CD268) may contribute to the pathogenesis of autoimmune diseases by enhancing the survival of autoreactive B cells.

BAFFR / TNFRSF13C Related Studies

  1. Ashkenazi A, et al. (1998) Death receptors: signaling and modulation. Science. 281(5381): 1305-8.
  2. Losi CG, et al. (2005) Mutational analysis of human BAFF receptor TNFRSF13C (BAFF-R) in patients with common variable immunodeficiency. J Clin Immunol. 25(5): 496-502.
  3. Hentges KE, et al. (2002) Tnfrsf13c (Baffr) is mis-expressed in tumors with murine leukemia virus insertions at Lvis22. Genomics. 80(2): 204-12.

TNF Superfamily Ligands

  • EDA-A1 / Ectodysplasin-A1*
  • TNFSF6 / CD95L / CD178*
  • TNFSF12 / TWEAK*
  • TNFSF13 / CD256*
  • TNFSF3 / TNFC / lymphotoxin beta*
  • TNFSF4*
  • TNFSF15*

TNF Receptor Superfamily

  • TNFRSF3 / CD18 / LTBR*
  • TNFRSF10C / CD263 / TRAILR3*
  • TNFRSF18*
  • TNFRSF12A / FN14 / TWEAKR*
 
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
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