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BACE1 / ASP2 Antibody, Mouse MAb

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    Human BACE1 Antibody Product Information
    Immunogen:Recombinant Human BACE1 protein (Catalog#10064-HCCH)
    Clone ID:1H6C2D4
    Ig Type:Mouse IgG1
    Concentration:
    Endotoxin:
    Formulation:0.2 μm filtered solution in PBS
    Preparation:This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human BACE1 extracellular domain (rhBACE1; Catalog#10064-HCCH; Met 1-Thr 457; NP_036236.1). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
    Other BACE1 Antibody Products
    Reactivity: Human  
    Application: ELISA  
      10064-RP03-50
      10064-RP03-200
      10064-RP03-100
      50 µg 
      200 µg 
      100 µg 
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      Reactivity: Human  
      Application: FCM  
      • Slide 1
      10064-R027-F-25
      10064-R027-F-100
      25 Test 
      100 Tests 
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      Reactivity: Human  
      Application: ELISA  
        10064-T16-50
        10064-T16-200
        10064-T16-100
        50 µg 
        200 µg 
        100 µg 
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        Reactivity: Human  
        Application: ELISA  
          10064-R001-50
          10064-R001-100
          50 µg 
          100 µg 
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          Reactivity: Human  
          Application: FCM  
          • Slide 1
          10064-R027-P-25
          10064-R027-P-100
          25 Test 
          100 Tests 
          Add to Cart
          Reactivity: Human  
          Application: FCM  IF  ICC/IF  
          • Slide 1
          • Slide 1
          10064-R027-50
          10064-R027-100
          50 µg 
          100 µg 
          Add to Cart
          Reactivity: Mouse  
          Application: ELISA  WB  IHC-P  
          • Slide 1
          • Slide 1
          50002-T48-50
          50002-T48-200
          50002-T48-100
          50 µg 
          200 µg 
          100 µg 
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          Reactivity: Mouse  
          Application: ELISA  
            50002-RP01-400
            50002-RP01-200
            50002-RP01-100
            400 µg 
            200 µg 
            100 µg 
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            BACE1 Background

            Beta-site APP-cleaving enzyme 1 (BACE1) is an aspartic-acid protease important in the formation of myelin sheaths in peripheral nerve cells. In the brain, This protein is expressed highly in the substantia nigra, locus coruleus and medulla oblongata. Strong BACE1 expression has also been described in pancreatic tissue. BACE1 has a pivotal role in the pathogenesis of Alzheimer's disease. In Alzheimer's disease patients, BACE1 levels were elevated although mRNA levels were not changed. It has been found that BACE1 gene expression is controlled by a TATA-less promoter. The translational repression as a new mechanism controlling its expression. And the low concentrations of Ca(2+) (microM range) significantly increased the proteolytic activity of BACE1. Furthermore, BACE1 protein is ubiquitinated, and the degradation of BACE1 proteins and amyloid precursor protein processing are regulated by the ubiquitin-proteasome pathway. It has also been identified as the rate limiting enzyme for amyloid-beta-peptide (Abeta) production.

            Human BACE1 References
          • Christensen MA, et al. (2004) Transcriptional regulation of BACE1, the beta-amyloid precursor protein beta-secretase, by Sp1. Mol Cell Biol. 24(2):865-74.
          • Stockley JH, et al. (2007) The proteins BACE1 and BACE2 and beta-secretase activity in normal and Alzheimer's disease brain. Biochem Soc Trans. 35(Pt 3): 574-6.
          • Savonenko AV, et al. (2008) Alteration of BACE1-dependent NRG1/ErbB4 signaling and schizophrenia-like phenotypes in BACE1-null mice. Proc Natl Acad Sci U S A. 105(14): 5585-90.
          • Hayley M, et al. (2009) Calcium enhances the proteolytic activity of BACE1: An in vitro biophysical and biochemical characterization of the BACE1-calcium interaction. Biochim Biophys Acta. 1788(9): 1933-8.
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            Catalog: 10064-MM01-100
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            Datasheet & Documentation

            All information of our products is subject to change without notice. Please refer to COA enclosed in shipped package for the newest information.
            Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"