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BACE1 / ASP2 Antibody (FITC), Rabbit MAb
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BACE1 / ASP2 Antibody (FITC), Rabbit MAb PDF Download

Catalog   Size (Price) Quantity In Stock Operation
10064-R027-F  
YES   
 

Primary antibody | Secondary antibody | Tag antibody | Isotype control antibody | Loading control antibody | Antibody Purification

BACE1 / ASP2 Antibody Datasheet

  Order or Inquire for BACE1 / ASP2 Antibody product Quality antibodies Antibody production services
 

BACE1 / ASP2 Antibody Product Information

Immunogen :

Recombinant Human BACE1 / ASP2 protein (Catalog#10064-HCCH)

Reagents : FITC-conjugated rabbit monoclonal antibody

Clone ID :

027

Ig Type :

Rabbit IgG

Concentration :

10 μl/Test, 0.1 mg/ml

Formulation : Aqueous solution containing 0.5% BSA and 0.09% sodium azide
Preparation :

This antibody was obtained from a rabbit immunized with purified, recombinant Human BACE1 / ASP2 (rh BACE1 / ASP2; Catalog#10064-HCCH; NP_036236.1; Met 1-Thr 457) and conjugated with FITC under optimum conditions, the unreacted FITC was removed.

BACE1 / ASP2 Antibody Usage Guide

Specificity :

Human BACE1 / ASP2

  Has cross-reactivity in ELISA with

Mouse BACE1

Human ADAM15

Flow Cytometry :
BACE1 / ASP2 Flow Cytometry

Flow cytometric analysis of Human BACE1 expression in Jurkat cells. The cells were treated according to manufacturer’s manual (BD Pharmingen™ Cat. No. 554714), and then stained with FITC Rabbit anti-BACE1 (10064-R027-F). The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells.

Flow cytometry was performed on a BD FACSCalibur flow cytometry system

Please refer to www.sinobiological.com/Flow-Cytometry-FACS-Protocols-a-750.html for technical protocols.

Storage : This antibody is stable for 12 months from date of receipt when stored at 2℃-8℃. Protected from prolonged exposure to light. Do not freeze !
Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.

BACE1 / ASP2 Antibody Related Products & Topics

BACE1 / ASP2 Antibody Related Areas:

Enzyme>>Protease & Regulator>>Aspartate Protease & Regulator>>BACE1/ASP2

Proteins:

Molecule Species Description //For Detailed Info. and Price------CLICK! Cat. No
BACE1/ASP2 Human BACE1/ASP2/Fc Protein, Recombinant 10064-H02H
BACE1/ASP2 Human BACE1/ASP2 Protein, Recombinant 10064-H08H
BACE1/ASP2 Human BACE1/ASP2 Protein, Recombinant 10064-HCCH
BACE1/ASP2 Mouse BACE1/ASP2 Protein, Recombinant 50002-M08H

Antibodies:

Molecule Application Description //For Detailed Info. and Price------CLICK! Cat. No
Human BACE1/ASP2 ELISA Mouse Monoclonal Antibody 10064-MM01
Human BACE1/ASP2 WB, ELISA Rabbit Monoclonal Antibody 10064-R001
Human BACE1/ASP2 WB, ELISA Rabbit Polyclonal Antibody (Antigen Affinity Purified) 10064-RP03
Human BACE1/ASP2 FCM BACE1 / ASP2 Antibody ( FITC ) 10064-R027-F

BACE1 / ASP2 Antibody Background

As a member of the peptidase A1 protein family, BACE1 is a type I integral membrane glycoprotein and aspartic protease that is found mainly in the Golgi. This protease is responsible for the proteolytic processing of the amyloid precursor protein (APP). APP is cleaved to generate a 40 or 42 amino acid-long amyloid-β peptide, which is the major constituent of amyloid plaques in the brains of individuals afflicted with Alzheimers disease (AD), and accordingly, BACE1 is implicated in the onset and progression of AD. The elevation of BACE1 levels can be induced by amyloid plaques surrounding neurons at early stages of pathology before neuron death occurs, and may drive a positive-feedback loop in AD. Different isoforms are derived from four transcript variants.

References

  1. Vassar, R. et al., 1999, Science. 286: 735-741.
  2. Yan, R. et al., 1999, Nature. 402: 533-537.
  3. Johnston, JA. et al., 2005, Biochem. Soc. Trans. Nov. 33:1096-1100.
  4. Zacchetti, D, et al., 2007, Neurodegener Dis. 4: 117-126.
  5. Zhao, J. et al., 2007, J. Neurosci. 27: 3639-3649.
 

 

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