B7-H3 / CD276 Protein & Antibody

B7 Homolog 3 / Cluster of Differentiation 276

B7-H3 / CD276 Products

B7-H3 / CD276 Protein, Recombinant

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
B7-H3/CD276	Human	B7-H3/CD276 Protein, Recombinant	11188-H08H

B7-H3 / CD276 Antibody

Molecule	Application	Description //For Detailed Info. and Price------CLICK!	Cat. No
Human B7-H3 / CD276	WB, ELISA	B7-H3 / CD276 Antibody (Antigen Affinity Purified)	11188-RP02
Human B7-H3 / CD276	WB, ELISA	B7-H3 / CD276 Antibody (Antigen Affinity Purified)	11188-MM06

B7-H3 / CD276 cDNA Clone

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
B7-H3/CD276	Human	Homo sapiens B7-H3/CD276 cDNA Clone	HG11188-M
B7-H3/CD276	Mouse	B7-H3/CD276 cDNA Clone / ORF Clone	MG50973-G
B7-H3/CD276	Rat	CD276 cDNA Clone / ORF Clone	RG80380-G

B7-H3 / CD276 Related Areas

Immunology>>Cluster of Differentiation>>T Cell CD Antigen / B Cell CD Antigen / Dendritic Cell CD Antigen / Natural Killer (NK) Cell CD Antigen>>B7-H3/CD276

Immunology>>Adaptive Immunity>>Costimulation & Costimulatory Molecule>>B7-H3/CD276

B7-H3 / CD276 Alternative Names

B7-H3, CD276, PSEC0249, 4Ig-B7-H3, B7H3 [Homo sapiens]

B7-H3, Cd276, 6030411F23Rik, AU016588, B7RP-2, B7h3 [Mus musculus]

B7-H3 / CD276 Background

B7-H3 is a member of the B7 family of immune regulatory ligands that is thought to attenuate peripheral immune responses through co-inhibition. It plays an important role in adaptive immune responses, and was shown to either promote or inhibit T-cell responses in various experimental systems. B7-H3 may play an important role in muscle-immune interactions, providing further evidence of the active role of muscle cells in local immunoregulatory processes. B7-H3 is a novel protein structurally related to the B7 family of ligands by the presence of a single set of immunoglobulin-V-like and immunoglobulin-C-like (VC) domains. Previous studies have correlated its overexpression with poor prognosis and decreased tumor-infiltrating lymphocytes in various carcinomas including uterine endometrioid carcinomas, and mounting evidence supports an immuno-inhibitory role in ovarian cancer prognosis. Recently, B7-H3 expression has been reported in several human cancers indicating an additional function of B7-H3 as a regulator of antitumor immunity.

B7-H3 / CD276 Related Studies

1. Suh WK, et al. (2004) The immune regulatory protein B7-H3 promotes osteoblast differentiation and bone mineralization. Proc Natl Acad Sci U S A. 101(35): 12969-73.
2. Waschbisch A, et al. (2008) Human muscle cells express the costimulatory molecule B7-H3, which modulates muscle-immune interactions. Arthritis Rheum. 58(11): 3600-8.
3. Loos M, et al. (2010) B7-h3 and its role in antitumor immunity. Clin Dev Immunol. 2010: 683875.
4. Zang X, et al. (2010) Tumor associated endothelial expression of B7-H3 predicts survival in ovarian carcinomas. Mod Pathol. 23(8): 1104-12.
5. Sun J, et al. (2010) Clinical significance and regulation of the costimulatory molecule B7-H3 in human colorectal carcinoma. Cancer Immunol Immunother. 59(8): 1163-71.