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B7-H3/CD276  Protein, Antibody, ELISA Kit, cDNA Clone

Expression host: Human Cells  
11188-H08H-50
11188-H08H-100
50 µg 
100 µg 
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Expression host: Human Cells  
11188-H02H-50
11188-H02H-100
50 µg 
100 µg 
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Expression host: Human Cells  
11188-H08H-B-50
11188-H08H-B-100
50 µg 
100 µg 
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Expression host: Human Cells  
50973-M08H-50
50973-M08H-100
50 µg 
100 µg 
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Expression host: Human Cells  
50973-M08H-B-50
50973-M08H-B-100
50 µg 
100 µg 
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Expression host: Human Cells  
80380-R08H-50
80380-R08H-100
50 µg 
100 µg 
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Expression host: Human Cells  
80380-R02H-50
80380-R02H-100
50 µg 
100 µg 
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Expression host: Human Cells  
90806-C08H-20
90806-C08H-100
20 µg 
100 µg 
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Expression host: Human Cells  
90806-C02H-50
90806-C02H-200
50 µg 
200 µg 
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B7-H3/CD276 Related Area

B7-H3/CD276 Related Pathways

    B7-H3/CD276 Summary & Protein Information

    B7-H3/CD276 Background

    Gene Summary: The protein encoded by this gene belongs to the immunoglobulin superfamily, and thought to participate in the regulation of T-cell-mediated immune response. Studies show that while the transcript of this gene is ubiquitously expressed in normal tissues and solid tumors, the protein is preferentially expressed only in tumor tissues. Additionally, it was observed that the 3' UTR of this transcript contains a target site for miR29 microRNA, and there is an inverse correlation between the expression of this protein and miR29 levels, suggesting regulation of expression of this gene product by miR29. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
    General information above from NCBI
    Subunit structure: Interacts with TREML2 and this interaction enhances T- cell activation.
    Subcellular location: Membrane; Single-pass type I membrane protein (Probable).
    Tissue specificity: Ubiquitous but not detectable in peripheral blood lymphocytes or granulocytes. Weakly expressed in resting monocytes. Expressed in dendritic cells derived from monocytes. Expressed in epithelial cells of sinonasal tissue. Expressed in extravillous trophoblast cells and Hofbauer cells of the first trimester placenta and term placenta.
    Induction: By bacterial lipopolysaccharides (LPS) in monocytes and by ionomycin in T and B-lymphocytes. Up-regulated in cells mediating rejection of human transplants.
    Sequence similarity: Belongs to the immunoglobulin superfamily. BTN/MOG family.
    Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
    Contains 2 Ig-like V-type (immunoglobulin-like) domains.
    General information above from UniProt

    B7-H3 is a member of the B7 family of immune regulatory ligands that is thought to attenuate peripheral immune responses through co-inhibition. It plays an important role in adaptive immune responses, and was shown to either promote or inhibit T-cell responses in various experimental systems. B7-H3 may play an important role in muscle-immune interactions, providing further evidence of the active role of muscle cells in local immunoregulatory processes. B7-H3 is a novel protein structurally related to the B7 family of ligands by the presence of a single set of immunoglobulin-V-like and immunoglobulin-C-like (VC) domains. Previous studies have correlated its overexpression with poor prognosis and decreased tumor-infiltrating lymphocytes in various carcinomas including uterine endometrioid carcinomas, and mounting evidence supports an immuno-inhibitory role in ovarian cancer prognosis. Recently, B7-H3 expression has been reported in several human cancers indicating an additional function of B7-H3 as a regulator of antitumor immunity.

    Immune Checkpoint
    Immune Checkpoint Detection: Antibodies   Immune Checkpoint Detection: ELISA Antibodies   Immune Checkpoint Detection: ICC Antibodies   Immune Checkpoint Detection: IP Antibodies   Immune Checkpoint Detection: FCM Antibodies   Immune Checkpoint Detection: WB Antibodies
    Immune Checkpoint Targets   Co-inhibitory Immune Checkpoint Targets

    Immunotherapy   Cancer Immunotherapy   Targeted Therapy

    B7-H3/CD276 Alternative Name

    B7-H3/CD276 Related Studies

  • Suh WK, et al. (2004) The immune regulatory protein B7-H3 promotes osteoblast differentiation and bone mineralization. Proc Natl Acad Sci U S A. 101(35): 12969-73.
  • Waschbisch A, et al. (2008) Human muscle cells express the costimulatory molecule B7-H3, which modulates muscle-immune interactions. Arthritis Rheum. 58(11): 3600-8.
  • Loos M, et al. (2010) B7-h3 and its role in antitumor immunity. Clin Dev Immunol. 2010: 683875.
  • Zang X, et al. (2010) Tumor associated endothelial expression of B7-H3 predicts survival in ovarian carcinomas. Mod Pathol. 23(8): 1104-12.
  • Sun J, et al. (2010) Clinical significance and regulation of the costimulatory molecule B7-H3 in human colorectal carcinoma. Cancer Immunol Immunother. 59(8): 1163-71.
  • Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"