Anti-B7-H3 Antibody (FITC)

Cat: 11188-MM06-F
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Anti-B7-H3 Antibody (FITC) (Mouse Monoclonal antibody) General Information
Product name
Anti-B7-H3 Antibody (FITC)
Validated applications
FCM
Species reactivity
Reacts with: Human
Specificity
Human B7-H3
Immunogen
Recombinant Human B7-H3 / CD276 protein (Catalog#11188-H08H)
Preparation
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human B7-H3 / CD276 (rh B7-H3 / CD276; Catalog#11188-H08H; Q5ZPR3-1; Met 1-Thr 461) and conjugated with FITC under optimum conditions, the unreacted FITC was removed.
Source
Monoclonal Mouse IgG2b Clone #06
Purification
Protein A
Formulation
Aqueous solution containing 0.5% BSA and 0.09% sodium azide
Conjugate
FITC
Concentration
10 μl/Test, 0.1 mg/ml
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for twelve months without detectable loss of activity. Protected from prolonged exposure to light. Do not freeze ! Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.
Anti-B7-H3 Antibody (FITC) (Mouse Monoclonal antibody) Validated Applications

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-B7-H3 Antibody (FITC) (Mouse Monoclonal antibody) Images
Human B7-H3/CD276 Flow Cytometry (FC) 5433
Flow cytometric analysis of anti-B7H3 (CD276) reactivity on PC-3 cells.
Anti-B7-H3 Antibody (FITC) Alternative Names
Anti-4Ig-B7-H3 Antibody;Anti-B7-H3 Antibody;Anti-B7H3 Antibody;Anti-B7RP-2 Antibody
B7-H3 Background Information

B7-H3 is a member of the B7 family of immune regulatory ligands that is thought to attenuate peripheral immune responses through co-inhibition. It plays an important role in adaptive immune responses, and was shown to either promote or inhibit T-cell responses in various experimental systems. B7-H3 may play an important role in muscle-immune interactions, providing further evidence of the active role of muscle cells in local immunoregulatory processes. B7-H3 is a novel protein structurally related to the B7 family of ligands by the presence of a single set of immunoglobulin-V-like and immunoglobulin-C-like (VC) domains. Previous studies have correlated its overexpression with poor prognosis and decreased tumor-infiltrating lymphocytes in various carcinomas including uterine endometrioid carcinomas, and mounting evidence supports an immuno-inhibitory role in ovarian cancer prognosis. Recently, B7-H3 expression has been reported in several human cancers indicating an additional function of B7-H3 as a regulator of antitumor immunity.

Immune Checkpoint
Immune Checkpoint Detection: Antibodies   Immune Checkpoint Detection: ELISA Antibodies   Immune Checkpoint Detection: ICC Antibodies   Immune Checkpoint Detection: IP Antibodies   Immune Checkpoint Detection: FCM Antibodies   Immune Checkpoint Detection: WB Antibodies
Immune Checkpoint Targets   Co-inhibitory Immune Checkpoint Targets

Immunotherapy   Cancer Immunotherapy   Targeted Therapy

Full Name
CD276 molecule
References
  • Suh WK, et al. (2004) The immune regulatory protein B7-H3 promotes osteoblast differentiation and bone mineralization. Proc Natl Acad Sci U S A. 101(35): 12969-73.
  • Waschbisch A, et al. (2008) Human muscle cells express the costimulatory molecule B7-H3, which modulates muscle-immune interactions. Arthritis Rheum. 58(11): 3600-8.
  • Loos M, et al. (2010) B7-h3 and its role in antitumor immunity. Clin Dev Immunol. 2010: 683875.
  • Zang X, et al. (2010) Tumor associated endothelial expression of B7-H3 predicts survival in ovarian carcinomas. Mod Pathol. 23(8): 1104-12.
  • Sun J, et al. (2010) Clinical significance and regulation of the costimulatory molecule B7-H3 in human colorectal carcinoma. Cancer Immunol Immunother. 59(8): 1163-71.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-B7-H3 Antibody Rabbit Polyclonal ELISA 80380-RP01
    Anti-B7-H3 Antibody Rabbit Polyclonal WB,ELISA,IP 80380-T52
    Anti-B7-H3 Antibody Rabbit Polyclonal ELISA 50973-RP01
    Anti-B7-H3 Antibody Rabbit Polyclonal WB,ELISA,IP 50973-T52
    Anti-B7-H3 Antibody Mouse Monoclonal ELISA 11188-M008
    Anti-B7-H3 Antibody Mouse Monoclonal ELISA(Cap) 11188-MM01
    Anti-B7-H3 Antibody Rabbit Polyclonal ELISA,IHC-P 11188-T24
    Anti-B7-H3 Antibody Mouse Monoclonal ELISA,ELISA(Det),FCM,ICC/IF,IF 11188-MM06
    Anti-B7-H3 Antibody Rabbit Polyclonal ELISA,IP 11188-RP02
    Anti-B7-H3 Antibody (APC) Mouse Monoclonal FCM 11188-MM06-A
    Anti-B7-H3 Antibody (PE) Mouse Monoclonal FCM 11188-MM06-P
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