After search, choose a molecule or a kind of categories listed in the left to narrow down your filter. If you have any problems, please contact us!
Text Size:AAA

B7-H3 / CD276 Antibody (FITC), Mouse MAb

DatasheetReviewsRelated ProductsProtocols
Human B7-H3/CD276 Antibody Product Information
Immunogen:Recombinant Human B7-H3 / CD276 protein (Catalog#11188-H08H)
Clone ID:06
Ig Type:Mouse IgG2b
Concentration:10 μl/Test, 0.1 mg/ml
Formulation:Aqueous solution containing 0.5% BSA and 0.09% sodium azide
Preparation:This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human B7-H3 / CD276 (rh B7-H3 / CD276; Catalog#11188-H08H; Q5ZPR3-1; Met 1-Thr 461) and conjugated with FITC under optimum conditions, the unreacted FITC was removed.
Human B7-H3/CD276 Antibody Usage Guide
Specificity:Human B7-H3 / CD276
No cross-reactivity in WB and ELISA with
Human cell lysate (293 cell line)
Application:FCM
Storage:This antibody is stable for 12 months from date of receipt when stored at 2℃-8℃. Protected from prolonged exposure to light. Do not freeze !
Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.
Human B7-H3/CD276 Antibody FC Application Image
B7-H3 / CD276 Antibody (FITC), Mouse MAb, Flow cytometric
[Click to enlarge image]
Caption:
Flow cytometric analysis of anti-B7H3 (CD276) reactivity on PC-3 cells.
Other B7-H3/CD276 Antibody Products
Reactivity: Human  
Application: ELISA  IP  
  • Slide 1
11188-RP02-50
11188-RP02-100
11188-RP02-200
50 µg 
100 µg 
200 µg 
Add to Cart
Reactivity: Human  
Application: ELISA  FCM  IF  ICC/IF  
  • Slide 1
  • Slide 1
11188-MM06-50
11188-MM06-100
11188-MM06-200
50 µg 
100 µg 
200 µg 
Add to Cart
Reactivity: Human  
Application: FCM  
  • Slide 1
11188-MM06-P-50
11188-MM06-P-100
50 Tests 
100 Tests 
Add to Cart
Reactivity: Human  
Application: FCM  
  • Slide 1
11188-MM06-A-100
11188-MM06-A-50
100 Tests 
50 Tests 
Add to Cart
Reactivity: Mouse  
Application: ELISA  WB  IP  
  • Slide 1
  • Slide 1
50973-T52-50
50973-T52-200
50973-T52-100
50 µg 
200 µg 
100 µg 
Add to Cart
Reactivity: Mouse  
Application: ELISA  
    50973-RP01-100
    50973-RP01-400
    50973-RP01-200
    100 µg 
     
    200 µg 
    Add to Cart
    Reactivity: Rat  
    Application: ELISA  
      80380-RP01-400
      80380-RP01-200
      80380-RP01-100
       
      200 µg 
      100 µg 
      Add to Cart
      Reactivity: Rat  
      Application: ELISA  WB  IP  
      • Slide 1
      • Slide 1
      80380-T52-200
      80380-T52-100
      80380-T52-50
      200 µg 
      100 µg 
      50 µg 
      Add to Cart
      B7-H3/CD276 Background

      B7-H3 is a member of the B7 family of immune regulatory ligands that is thought to attenuate peripheral immune responses through co-inhibition. It plays an important role in adaptive immune responses, and was shown to either promote or inhibit T-cell responses in various experimental systems. B7-H3 may play an important role in muscle-immune interactions, providing further evidence of the active role of muscle cells in local immunoregulatory processes. B7-H3 is a novel protein structurally related to the B7 family of ligands by the presence of a single set of immunoglobulin-V-like and immunoglobulin-C-like (VC) domains. Previous studies have correlated its overexpression with poor prognosis and decreased tumor-infiltrating lymphocytes in various carcinomas including uterine endometrioid carcinomas, and mounting evidence supports an immuno-inhibitory role in ovarian cancer prognosis. Recently, B7-H3 expression has been reported in several human cancers indicating an additional function of B7-H3 as a regulator of antitumor immunity.

      Human B7-H3/CD276 References
    • Suh WK, et al. (2004) The immune regulatory protein B7-H3 promotes osteoblast differentiation and bone mineralization. Proc Natl Acad Sci U S A. 101(35): 12969-73.
    • Waschbisch A, et al. (2008) Human muscle cells express the costimulatory molecule B7-H3, which modulates muscle-immune interactions. Arthritis Rheum. 58(11): 3600-8.
    • Loos M, et al. (2010) B7-h3 and its role in antitumor immunity. Clin Dev Immunol. 2010: 683875.
    • Zang X, et al. (2010) Tumor associated endothelial expression of B7-H3 predicts survival in ovarian carcinomas. Mod Pathol. 23(8): 1104-12.
    • Sun J, et al. (2010) Clinical significance and regulation of the costimulatory molecule B7-H3 in human colorectal carcinoma. Cancer Immunol Immunother. 59(8): 1163-71.
    • Product nameProduct name
      Size / Price
      Catalog: 11188-MM06-F-50
      List Price: 
      Price:      (You Save: )
      Size:
      50 Tests
      100 Tests
      Quantity:+-
      AvailabilityIn Stock
      Bulk Discount InquiryAdd to Cart
      All information of our products is subject to change without notice. Please refer to COA enclosed in shipped package for the newest information.
      Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"