B7-DC / PD-L2 Protein & Antibody (CD273)

Programmed Death 1-Ligand 2 (Cluster of Differentiation 273)

B7-DC / PD-L2 Products

B7-DC / PD-L2 Protein, Recombinant

Molecule	Species	Description	Cat. No
B7-DC/PD-L2/CD273	Human	B7-DC/PD-L2/CD273/Fc Protein, Recombinant	10292-H03H
B7-DC/PD-L2/CD273	Human	B7-DC/PD-L2/CD273 Protein, Recombinant	10292-H08H
B7-DC/PD-L2/CD273	Mouse	PDCD1LG2 / B7-DC / PD-L2 Protein, Recombinant	50804-M02H
B7-DC/PD-L2/CD273	Mouse	B7-DC / PD-L2 / PDCD1LG2 Protein, Recombinant	50804-M08H

  10292-H03H: Immobilized human PD1 at 2 µg/ml (100 µl/well) can bind human PD-L2 with a linear ranger of 0.0064-0.16 µg/ml.Measured by its binding ability in a functional ELISA.

  10292-H08H: Immobilized recombinant human PD-L2 at 1µg/ml (100µl/well) can bind recombinant human PD1 with a linear range of 7.8-1000 ng/ml.Measured by its binding ability in a functional ELISA.

B7-DC / PD-L2 Antibody

Molecule	Application	Description	Cat. No
Human B7-DC/PD-L2/CD273	WB, ELISA	B7-DC/PD-L2/CD273 Antibody, Rabbit MAb	10292-R018
Human B7-DC/PD-L2/CD273	WB, ELISA	Rabbit Polyclonal Antibody	10292-RP01
Human B7-DC/PD-L2/CD273	WB, ELISA	Rabbit Polyclonal Antibody (Antigen Affinity Purified)	10292-RP02

B7-DC / PD-L2 cDNA Clone

Molecule	Species	Description	Cat. No
B7-DC/PD-L2/CD273	Human	Homo sapiens B7-DC/PD-L2/CD273 cDNA Clone(NM_025239.3)	HG10292-M

B7-DC / PD-L2 Related Areas

Immunology>>Adaptive Immunity>>Costimulation & Costimulatory Molecule>>B7-DC/PD-L2/CD273

Immunology>>Cluster of Differentiation>>Monocyte/Macrophage CD Antigen>>Macrophage Markers / Monocyte Markers>>B7-DC/PD-L2/CD273

B7-DC / PD-L2 Alternative Names

B7DC, PD-L2, CD273, PDCD1LG2, Btdc, MGC142238, MGC142240, PDCD1L2, PDL2, bA574F11.2 [Homo sapiens]

B7-DC, PD-L2, Pdcd1lg2, Btdc, F730015O22Rik, MGC124039, MGC124040, [Mus musculus]

B7-DC / PD-L2 Background

Programmed death ligand 2 (PD-L2), also referred to as B7-DC and CD273, is a member of the B7 family of proteins including B7-1, B7-2, B7-H2, B7-H1 (PD-L1), and B7-H3. PD-L2 is a type I membrane protein and structurally consists of an extracellular region containing one V-like and one C-like Ig domain, a transmembrane region, and a short cytoplasmic domain. PD-L2 is expressed on antigen presenting cells, placental endothelium and medullary thymic epithelial cells, and can be induced by LPS in B cells, INF-γ in monocytes, or LPS plus IFN-γ in dendritic cells. The CD28 and B7 protein families are critical regulators of immune responses. PD-L2 and PD-L1 are two ligands for PD-1, member of the CD28/CTLA4 family expressed on activated lymphoid cells, and thus provide signals for regulating T cell activation and immune tolerance. The interaction of B7-DC/PD-1 exhibited a 2-6-fold higher affinity compared with the interaction of B7-H1/PD-1.

B7-DC / PD-L2 Related Studies

1. Latchman Y, et al. (2001) PD-L2 is a second ligand for PD-1 and inhibits T cell activation. Nat Immunol. 2: 261-8.
2. Carreno BM, et al. (2005) Therapeutic opportunities in the B7/CD28 family of ligands and receptors. Curr Opin Pharmacol. 5(4): 424-30.
3. Radhakrishnan S, et al. (2007) B7-DC/PD-L2 cross-linking induces NF-kappaB-dependent protection of dendritic cells from cell death. J Immunol. 178(3): 1426-32.