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B7-DC/PD-L2/CD273 Protein, Antibody, ELISA Kit, cDNA Clone

Expression host: Human Cells
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10292-H02H-200
10292-H02H-100
200 µg / $298
100 µg / $198
Add to Cart
Description: Active
Expression host: Human Cells
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10292-H03H-100
10292-H03H-200
100 µg / $178
200 µg / $298
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Description: Active
Expression host: Human Cells
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10292-H08H-50
10292-H08H-100
50 µg / $198
100 µg / $348
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Description: Active
Expression host: Human Cells
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50804-M08H-100
50804-M08H-200
100 µg / $178
200 µg / $298
Add to Cart
Description: Active
Expression host: Human Cells
  • Slide 1
50804-M02H-100
50804-M02H-200
100 µg / $178
200 µg / $298
Add to Cart
Expression host: Human Cells
  • Slide 1
90249-C02H-100
90249-C02H-200
100 µg / $198
200 µg / $298
Add to Cart
Expression host: Human Cells
  • Slide 1
90249-C08H-100
90249-C08H-200
100 µg / $198
200 µg / $298
Add to Cart

B7-DC/PD-L2/CD273 Related Areas

B7-DC/PD-L2/CD273 Related Pathways

B7-DC/PD-L2/CD273 Related Product

    B7-DC/PD-L2/CD273 Summary & Protein Information

    B7-DC/PD-L2/CD273 Background

    Gene Summary: OMIM - description for B7-DC (PD-L2, CD273):
    General information above from NCBI
    Subunit structure: Interacts with PDCD1 (By similarity).
    Subcellular location: Isoform 3: Secreted (Probable).
    Isoform 2: Endomembrane system; Single-pass type I membrane protein.
    Isoform 1: Cell membrane; Single-pass type I membrane protein.
    Tissue specificity: Highly expressed in heart, placenta, pancreas, lung and liver and weakly expressed in spleen, lymph nodes and thymus.
    Induction: Up-regulated by IFNG/IFN-gamma stimulation in monocytes and induced on dendritic cells grown from peripheral blood mononuclear cells with CSF2 and IL4/interleukin-4.
    Sequence similarity: Belongs to the immunoglobulin superfamily. BTN/MOG family.
    Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
    Contains 1 Ig-like V-type (immunoglobulin-like) domain.C
    General information above from UniProt

    Programmed death ligand 2 (PD-L2), also referred to as B7-DC and CD273, is a member of the B7 family of proteins including B7-1, B7-2, B7-H2, B7-H1 (PD-L1), and B7-H3. PD-L2 is a type I membrane protein and structurally consists of an extracellular region containing one V-like and one C-like Ig domain, a transmembrane region, and a short cytoplasmic domain. PD-L2 is expressed on antigen presenting cells, placental endothelium and medullary thymic epithelial cells, and can be induced by LPS in B cells, INF-γ in monocytes, or LPS plus IFN-γ in dendritic cells. The CD28 and B7 protein families are critical regulators of immune responses. PD-L2 and PD-L1 are two ligands for PD-1, member of the CD28/CTLA4 family expressed on activated lymphoid cells, and thus provide signals for regulating T cell activation and immune tolerance. The interaction of B7-DC/PD-1 exhibited a 2-6-fold higher affinity compared with the interaction of B7-H1/PD-1.

    B7-DC/PD-L2/CD273 Alternative Name

    B7-DC/PD-L2/CD273 Related Studies

  • Latchman Y, et al. (2001) PD-L2 is a second ligand for PD-1 and inhibits T cell activation. Nat Immunol. 2: 261-8.
  • Carreno BM, et al. (2005) Therapeutic opportunities in the B7/CD28 family of ligands and receptors. Curr Opin Pharmacol. 5(4): 424-30.
  • Radhakrishnan S, et al. (2007) B7-DC/PD-L2 cross-linking induces NF-kappaB-dependent protection of dendritic cells from cell death. J Immunol. 178(3): 1426-32.
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