Anti-PD-L2 Antibody

Cat: 10292-R018
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Anti-PD-L2 Antibody (Rabbit Monoclonal antibody) General Information
Product name
Anti-PD-L2 Antibody
Validated applications
Species reactivity
Reacts with: Human
Human PD-L2
Has cross-reactivity in ELISA with Human B7-H2 / ICOSL / CD275 Mouse CD86 / B7-2 / B70 Mouse B7-H1 / CD274 / PD-L1
No cross-reactivity in ELISA with Human CD80 / B7-1 Human CD86 / B7-2 / B70 Mouse B7-H2 / ICOSL / CD275
Recombinant Human PD-L2 protein (Catalog#10292-H08H)
This antibody was obtained from a rabbit immunized with purified, recombinant Human PD-L2 / CD273 (rh PD-L2; Catalog#10292-H08H; NP_079515.2; Met 1-Pro 219).
Monoclonal Rabbit IgG Clone #18
Protein A
0.2 μm filtered solution in PBS
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-PD-L2 Antibody (Rabbit Monoclonal antibody) Validated Applications
Application Dilution Notes
WB 1:500-1:2000  
ELISA 1:1000-1:2000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-PD-L2 Antibody (Rabbit Monoclonal antibody) Images
Human PD-L2/B7-DC/CD273 Western blot (WB) 13169

Anti-PD-L2 rabbit monoclonal antibody at 1:500 dilution

Lane A: Raji Whole Cell Lysate

Lysates/proteins at 30 μg per lane.


Goat Anti-Rabbit IgG H&L (Dylight800) at 1/10000 dilution.

Developed using the Odyssey technique.

Performed under reducing conditions.

Predicted band size:31 kDa

Observed band size:45 kDa

(We are unsure as to the identity of these extra bands.)

Anti-PD-L2 Antibody Alternative Names
Anti-B7-DC Antibody;Anti-B7DC Antibody;Anti-bA574F11.2 Antibody;Anti-Btdc Antibody;Anti-CD273 Antibody;Anti-PD-L2 Antibody;Anti-PDCD1L2 Antibody;Anti-PDL2 Antibody
PD-L2 Background Information

Programmed death ligand 2 (PD-L2), also referred to as B7-DC and CD273, is a member of the B7 family of proteins including B7-1, B7-2, B7-H2, B7-H1 (PD-L1), and B7-H3. PD-L2 is a type I membrane protein and structurally consists of an extracellular region containing one V-like and one C-like Ig domain, a transmembrane region, and a short cytoplasmic domain. PD-L2 is expressed on antigen presenting cells, placental endothelium and medullary thymic epithelial cells, and can be induced by LPS in B cells, INF-γ in monocytes, or LPS plus IFN-γ in dendritic cells. The CD28 and B7 protein families are critical regulators of immune responses. PD-L2 and PD-L1 are two ligands for PD-1, member of the CD28/CTLA4 family expressed on activated lymphoid cells, and thus provide signals for regulating T cell activation and immune tolerance. The interaction of B7-DC/PD-1 exhibited a 2-6-fold higher affinity compared with the interaction of B7-H1/PD-1.

Immune Checkpoint
Immune Checkpoint Detection: Antibodies   Immune Checkpoint Detection: ELISA Antibodies   Immune Checkpoint Detection: FCM Antibodies   Immune Checkpoint Detection: WB Antibodies
Immune Checkpoint Proteins
Immune Checkpoint Targets   Co-inhibitory Immune Checkpoint Targets

Immunotherapy   Cancer Immunotherapy   Targeted Therapy

Full Name
programmed cell death 1 ligand 2
  • Latchman Y, et al. (2001) PD-L2 is a second ligand for PD-1 and inhibits T cell activation. Nat Immunol. 2: 261-8.
  • Carreno BM, et al. (2005) Therapeutic opportunities in the B7/CD28 family of ligands and receptors. Curr Opin Pharmacol. 5(4): 424-30.
  • Radhakrishnan S, et al. (2007) B7-DC/PD-L2 cross-linking induces NF-kappaB-dependent protection of dendritic cells from cell death. J Immunol. 178(3): 1426-32.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-PD-L2 Antibody Rabbit Polyclonal ELISA 50804-T16
    Anti-PD-L2 Antibody Rabbit Monoclonal ELISA 50804-R208
    Anti-PD-L2 Antibody Rabbit Polyclonal ELISA 50804-RP01
    Anti-PD-L2 Antibody Rabbit Polyclonal ELISA 10292-RP02
    Anti-PD-L2 Antibody Rabbit Polyclonal ELISA,IHC-P 10292-T24
    Anti-PD-L2 Antibody Rabbit Polyclonal ELISA 10292-RP01
    Anti-PD-L2 Antibody Rabbit Monoclonal FCM 10292-R002
    Anti-PD-L2 Antibody Mouse Monoclonal ELISA(Cap) 10292-M324
    Anti-PD-L2 Antibody (FITC) Rabbit Monoclonal FCM 10292-R002-F
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