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B7-DC / PD-L2 / CD273 Antibody, Rabbit MAb

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Human PD-L2 Antibody Product Information
Immunogen:Recombinant Human PD-L2 protein (Catalog#10292-H08H)
Clone ID:18
Ig Type:Rabbit IgG
Concentration:
Endotoxin:
Formulation:0.2 μm filtered solution in PBS with 5% trehalose
Preparation:This antibody was obtained from a rabbit immunized with purified, recombinant Human PD-L2 / CD273 (rh PD-L2; Catalog#10292-H08H; NP_079515.2; Met 1-Pro 219).
Human PD-L2 Antibody Usage Guide
Specificity:Human PD-L2 / CD273 / B7-DC
Has cross-reactivity in ELISA with
Human B7-H2 / ICOSL / CD275
Mouse CD86 / B7-2 / B70
Mouse B7-H1 / CD274 / PD-L1
No cross-reactivity in ELISA with
Human CD80 / B7-1
Human CD86 / B7-2 / B70
Mouse B7-H2 / ICOSL / CD275
Application:WB, ELISA

WB: 2-5 μg/ml

ELISA: 0.5-1 μg/mL

This antibody can be used at 0.5-1 μg/mL with the appropriate secondary reagents to detect Human PDL2. The detection limit for Human PDL2 is 0.00245 ng/well.

Storage:This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Human PD-L2 Antibody WB Application Image
Other PD-L2 Antibody Products
Reactivity: Human  
Application: FCM  
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10292-R002-F-100
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Reactivity: Human  
Application: ELISA  
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    Reactivity: Human  
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      10292-RP02-50
      10292-RP02-100
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      Reactivity: Human  
      Application: FCM  
      • Slide 1
      10292-R002-50
      10292-R002-100
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      Reactivity: Mouse  
      Application: ELISA  
        50804-T16-200
        50804-T16-100
        50804-T16-50
        200 µg 
        100 µg 
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        Reactivity: Mouse  
        Application: ELISA  
          50804-RP01-400
          50804-RP01-100
          50804-RP01-200
           
          100 µg 
          200 µg 
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          PD-L2/B7-DC/CD273 Background

          Programmed death ligand 2 (PD-L2), also referred to as B7-DC and CD273, is a member of the B7 family of proteins including B7-1, B7-2, B7-H2, B7-H1 (PD-L1), and B7-H3. PD-L2 is a type I membrane protein and structurally consists of an extracellular region containing one V-like and one C-like Ig domain, a transmembrane region, and a short cytoplasmic domain. PD-L2 is expressed on antigen presenting cells, placental endothelium and medullary thymic epithelial cells, and can be induced by LPS in B cells, INF-γ in monocytes, or LPS plus IFN-γ in dendritic cells. The CD28 and B7 protein families are critical regulators of immune responses. PD-L2 and PD-L1 are two ligands for PD-1, member of the CD28/CTLA4 family expressed on activated lymphoid cells, and thus provide signals for regulating T cell activation and immune tolerance. The interaction of B7-DC/PD-1 exhibited a 2-6-fold higher affinity compared with the interaction of B7-H1/PD-1.

          Human PD-L2/B7-DC/CD273 References
        • Latchman Y, et al. (2001) PD-L2 is a second ligand for PD-1 and inhibits T cell activation. Nat Immunol. 2: 261-8.
        • Carreno BM, et al. (2005) Therapeutic opportunities in the B7/CD28 family of ligands and receptors. Curr Opin Pharmacol. 5(4): 424-30.
        • Radhakrishnan S, et al. (2007) B7-DC/PD-L2 cross-linking induces NF-kappaB-dependent protection of dendritic cells from cell death. J Immunol. 178(3): 1426-32.
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          Size / Price
          Catalog: 10292-R018-50
          List Price: 
          Price:      (You Save: )
          Size:
          50 µg
          100 µg
          Quantity:+-
          AvailabilityIn Stock
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          All information of our products is subject to change without notice. Please refer to COA enclosed in shipped package for the newest information.
          Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"