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B7-DC / PD-L2 / CD273 Antibody, Rabbit MAb

  • B7-DC / PD-L2 / CD273 Antibody, Rabbit MAb, Western blot
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Human PD-L2 Antibody Product Information
Immunogen:Recombinant Human PD-L2 protein (Catalog#10292-H08H)
Clone ID:18
Ig Type:Rabbit IgG
Concentration:
Endotoxin:
Formulation:0.2 μm filtered solution in PBS
Preparation:This antibody was obtained from a rabbit immunized with purified, recombinant Human PD-L2 / CD273 (rh PD-L2; Catalog#10292-H08H; NP_079515.2; Met 1-Pro 219).
Human PD-L2 Antibody WB Application Image
Other PD-L2 Antibody Products
Reactivity: Human  
Application: FCM  
  • Slide 1
10292-R002-F-100
10292-R002-F-50
100 Tests 
50 Tests 
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Reactivity: Human  
Application: ELISA  
    10292-RP01-100
    10292-RP01-200
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    200 µg 
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    Reactivity: Human  
    Application: ELISA  
      10292-RP02-50
      10292-RP02-100
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      Reactivity: Human  
      Application: FCM  
      • Slide 1
      10292-R002-50
      10292-R002-100
      50 µg 
      100 µg 
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      Reactivity: Mouse  
      Application: ELISA  
        50804-T16-200
        50804-T16-100
        50804-T16-50
        200 µg 
        100 µg 
        50 µg 
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        Reactivity: Mouse  
        Application: ELISA  
          50804-RP01-400
          50804-RP01-100
          50804-RP01-200
           
          100 µg 
          200 µg 
          Add to Cart
          PD-L2/B7-DC/CD273 Background

          Programmed death ligand 2 (PD-L2), also referred to as B7-DC and CD273, is a member of the B7 family of proteins including B7-1, B7-2, B7-H2, B7-H1 (PD-L1), and B7-H3. PD-L2 is a type I membrane protein and structurally consists of an extracellular region containing one V-like and one C-like Ig domain, a transmembrane region, and a short cytoplasmic domain. PD-L2 is expressed on antigen presenting cells, placental endothelium and medullary thymic epithelial cells, and can be induced by LPS in B cells, INF-γ in monocytes, or LPS plus IFN-γ in dendritic cells. The CD28 and B7 protein families are critical regulators of immune responses. PD-L2 and PD-L1 are two ligands for PD-1, member of the CD28/CTLA4 family expressed on activated lymphoid cells, and thus provide signals for regulating T cell activation and immune tolerance. The interaction of B7-DC/PD-1 exhibited a 2-6-fold higher affinity compared with the interaction of B7-H1/PD-1.

          Immune Checkpoint
          Immune Checkpoint Detection: Antibodies   Immune Checkpoint Detection: ELISA Antibodies   Immune Checkpoint Detection: FCM Antibodies   Immune Checkpoint Detection: WB Antibodies
          Immune Checkpoint Proteins
          Immune Checkpoint Targets   Co-inhibitory Immune Checkpoint Targets

          Immunotherapy   Cancer Immunotherapy   Targeted Therapy

          Human PD-L2/B7-DC/CD273 References
        • Latchman Y, et al. (2001) PD-L2 is a second ligand for PD-1 and inhibits T cell activation. Nat Immunol. 2: 261-8.
        • Carreno BM, et al. (2005) Therapeutic opportunities in the B7/CD28 family of ligands and receptors. Curr Opin Pharmacol. 5(4): 424-30.
        • Radhakrishnan S, et al. (2007) B7-DC/PD-L2 cross-linking induces NF-kappaB-dependent protection of dendritic cells from cell death. J Immunol. 178(3): 1426-32.
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          Catalog: 10292-R018-50
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          Datasheet & Documentation

          All information of our products is subject to change without notice. Please refer to COA enclosed in shipped package for the newest information.
          Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"