B2M / beta-2 microglobulin Protein & Antibody

B2M / beta-2 microglobulin Products

B2M / beta-2 microglobulin Protein, Recombinant

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
B2M/beta-2 microglobulin	Human	B2M/beta-2 microglobulin Protein, Recombinant	11976-H08H
B2M/beta-2 microglobulin	Mouse	B2M / Beta-2-microglobulin Protein, Recombinant	50957-M08H
B2M/beta-2 microglobulin	Rat	B2M / Beta-2-microglobulin Protein, Recombinant	80423-R08H
B2M/beta-2 microglobulin	Cynomulgus	B2M / Beta-2-microglobulin Protein, Recombinant	90152-C08H

B2M / beta-2 microglobulin Antibody

Molecule	Application	Description //For Detailed Info. and Price------CLICK!	Cat. No
Human B2M/beta-2 microglobulin	WB, ELISA	B2M / beta-2 microglobulin Antibody	11976-MM04
Human B2M/beta-2 microglobulin	WB, ELISA	B2M / beta-2 microglobulin Antibody	11976-RP01
Human B2M/beta-2 microglobulin	WB, ELISA	B2M / beta-2 microglobulin Antibody (Antigen Affinity Purified)	11976-RP02

B2M / beta-2 microglobulin cDNA Clone

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
B2M/beta-2 microglobulin	Human	Homo sapiens B2M/beta-2 microglobulin cDNA Clone	HG11976-G
B2M/beta-2 microglobulin	Mouse	Mouse B2M/beta-2 microglobulin cDNA Clone / ORF Clone	MG50957-G
B2M/beta-2 microglobulin	Cynomolgus	Cynomolgus monkey B2M Gene cDNA Clone / ORF Clone	KG90152-G

B2M / beta-2 microglobulin Related Areas

Immunology>>Adaptive Immunity>>Major Histocompatibility Complex>>B2M/beta-2 microglobulin

B2M / beta-2 microglobulin Alternative Names

B2M, beta-2 microglobulin, CDABP0092, beta-2-microglobin [Homo sapiens]

B2m, beta-2 microglobulin, RP23-34E24.5, Ly-m11, beta2-m, beta2m, beta-2-microglobin [Mus musculus]

B2M / beta-2 microglobulin Protein Background

B2M, also known as β2-Microglobulin or CDABP0092, is a component of MHC class I molecules found expression in all nucleated cells (excludes red blood cells). The major function of MHC class I moleculesis is to display fragments of proteins from within the cell to T-cells and cells containing foreign proteins will be attacked. B2M(β2-Microglobulin) is a low molecular weight protein. It was demonstrated that B2M(β2-Microglobulin) was localized in the membranes of nucleated cells and was found to be associated with HL-A antigens.B2M(β2- Microglobulin) is present in free form in various body fluids and as a subunit of histocompatibility antigens on cell surfaces lateral to theα3 chain. Unlikeα3, β2 has no transmembrane region. Directly above β2 lies the α1 chain, which itself is lateral to the α2. In the absence of B2M(β2 microglobulin), very limited amounts of MHC class I (classical and non-classical) molecules can be detected on the surface. In the absence of MHC class I, CD8 T cells, a subset of T cells involved in the development of acquired immunity cannot develop. Low levels of B2M(β2 microglobulin) can indicate non-progression of HIV.

B2M / beta-2 microglobulin Protein Related Studies

1. Poulik MD, et al. (1979) Beta 2-Microglobulin: methods and clinical applications. CRC Ctit Rev Clin Lab Sci. 10(3): 225-45.
2. Poulik MD, et al. (1975) Beta2-Microglobulins. Contemp Top Mol Immunol. 4: 157-204.
3. Berggard I. (1976) Beta2-Microglobulins: isolation, properties, and distribution. Fed Proc. 35(5): 1167-70.