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B2M / beta-2 microglobulin Antibody, Rabbit MAb

  • B2M / beta-2 microglobulin Antibody, Rabbit MAb, Immunoprecipitation
  • B2M / beta-2 microglobulin Antibody, Rabbit MAb, Western blot
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Human B2M Antibody Product Information
Immunogen:Recombinant Human B2M / beta-2 microglobulin protein (Catalog#11976-H08H)
Clone ID:201
Ig Type:Rabbit IgG
Concentration:
Endotoxin:
Formulation:0.2 μm filtered solution in PBS with 5% trehalose
Preparation:This antibody was obtained from a rabbit immunized with purified, recombinant Human B2M / beta-2 microglobulin (rh B2M / beta-2 microglobulin; Catalog#11976-H08H; NP_004039.1; Met 1-Met 119).
Human B2M Antibody WB Application Image
Human B2M Antibody IP Application Image
Other B2M Antibody Products
Reactivity: Human  
Application: IHC-P  IF  ICC/IF  
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11976-R209-50
11976-R209-100
50 µg 
100 µg 
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Reactivity: Human  
Application: FCM  IF  ICC/IF  
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11976-MM01-50
11976-MM01-200
11976-MM01-100
50 µg 
200 µg 
100 µg 
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Reactivity: Human  
Application: ELISA  IHC-P  
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11976-MM04-50
11976-MM04-200
11976-MM04-100
50 µg 
200 µg 
100 µg 
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Reactivity: Human  
Application: ELISA  
    11976-RP01-400
    11976-RP01-200
    11976-RP01-100
    400 µg 
    200 µg 
    100 µg 
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    Reactivity: Human  
    Application: FCM  
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    11976-MM01-P-25
    11976-MM01-P-100
    25 Test 
    100 Tests 
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    Reactivity: Human  
    Application: FCM  
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    11976-MM01-F-25
    11976-MM01-F-100
    25 Test 
    100 Tests 
    Add to Cart
    Reactivity: Human  
    Application: ELISA  WB  IP  
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    11976-RP02-50
    11976-RP02-200
    11976-RP02-100
    50 µg 
    200 µg 
    100 µg 
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    Reactivity: Mouse  
    Application: ELISA  
      50957-RP01-400
      50957-RP01-200
      50957-RP01-100
      400 µg 
      200 µg 
      100 µg 
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      Reactivity: Mouse  
      Application: ELISA  IHC-P  
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      50957-RP02-50
      50957-RP02-200
      50957-RP02-100
      50 µg 
      200 µg 
      100 µg 
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      Reactivity: Rat  
      Application: ELISA  
        80423-RP01-400
        80423-RP01-200
        80423-RP01-100
        400 µg 
        200 µg 
        100 µg 
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        Reactivity: Rat  
        Application: ELISA  WB  IHC-P  
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        80423-T56-50
        80423-T56-200
        80423-T56-100
        50 µg 
        200 µg 
        100 µg 
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        Reactivity: Rat  
        Application: IHC-P  
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        80423-R035-50
        80423-R035-100
        50 µg 
        100 µg 
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        Reactivity: Cynomolgus  
        Application: ELISA  
          90152-RP01-400
          90152-RP01-200
          90152-RP01-100
          400 µg 
          200 µg 
          100 µg 
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          Reactivity: Cynomolgus  
          Application: ELISA  WB  IP  
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          90152-T52-50
          90152-T52-200
          90152-T52-100
          50 µg 
          200 µg 
          100 µg 
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          Beta-2 microglobulin/B2M Background

          B2M, also known as β2-Microglobulin or CDABP0092, is a component of MHC class I molecules found expression in all nucleated cells (excludes red blood cells). The major function of MHC class I moleculesis is to display fragments of proteins from within the cell to T-cells and cells containing foreign proteins will be attacked. B2M(β2-Microglobulin) is a low molecular weight protein. It was demonstrated that B2M(β2-Microglobulin) was localized in the membranes of nucleated cells and was found to be associated with HL-A antigens.B2M(β2- Microglobulin) is present in free form in various body fluids and as a subunit of histocompatibility antigens on cell surfaces lateral to theα3 chain. Unlikeα3, β2 has no transmembrane region. Directly above β2 lies the α1 chain, which itself is lateral to the α2. In the absence of B2M(β2 microglobulin), very limited amounts of MHC class I (classical and non-classical) molecules can be detected on the surface. In the absence of MHC class I, CD8 T cells, a subset of T cells involved in the development of acquired immunity cannot develop. Low levels of B2M(β2 microglobulin) can indicate non-progression of HIV.

          Human Beta-2 microglobulin/B2M References
        • Poulik MD, et al. (1979) Beta 2-Microglobulin: methods and clinical applications. CRC Ctit Rev Clin Lab Sci. 10(3): 225-45.
        • Poulik MD, et al. (1975) Beta2-Microglobulins. Contemp Top Mol Immunol. 4: 157-204.
        • Berggard I. (1976) Beta2-Microglobulins: isolation, properties, and distribution. Fed Proc. 35(5): 1167-70.
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          Catalog: 11976-R201-50
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          Datasheet & Documentation

          All information of our products is subject to change without notice. Please refer to COA enclosed in shipped package for the newest information.
          Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"