Anti-Beta-2 microglobulin Antibody

Cat: 50957-RP01
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Anti-Beta-2 microglobulin Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-Beta-2 microglobulin Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Mouse
Specificity
Mouse Beta-2 microglobulin
Immunogen
Recombinant Mouse B2M / Beta-2-microglobulin protein (Catalog#50957-M08H)
Preparation
Produced in rabbits immunized with purified, recombinant Mouse B2M / Beta-2-microglobulin (rM B2M / Beta-2-microglobulin; Catalog#50957-M08H; P01887; Met1-Met119). Total IgG was purified by Protein A affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-Beta-2 microglobulin Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:1000-1:2000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-Beta-2 microglobulin Antibody Alternative Names
Anti-beta2-m Antibody;Anti-beta2m Antibody;Anti-Ly-m11 Antibody
Beta-2 microglobulin Background Information

B2M, also known as β2-Microglobulin or CDABP0092, is a component of MHC class I molecules found expression in all nucleated cells (excludes red blood cells). The major function of MHC class I moleculesis is to display fragments of proteins from within the cell to T-cells and cells containing foreign proteins will be attacked. B2M(β2-Microglobulin) is a low molecular weight protein. It was demonstrated that B2M(β2-Microglobulin) was localized in the membranes of nucleated cells and was found to be associated with HL-A antigens.B2M(β2- Microglobulin) is present in free form in various body fluids and as a subunit of histocompatibility antigens on cell surfaces lateral to theα3 chain. Unlikeα3, β2 has no transmembrane region. Directly above β2 lies the α1 chain, which itself is lateral to the α2. In the absence of B2M(β2 microglobulin), very limited amounts of MHC class I (classical and non-classical) molecules can be detected on the surface. In the absence of MHC class I, CD8 T cells, a subset of T cells involved in the development of acquired immunity cannot develop. Low levels of B2M(β2 microglobulin) can indicate non-progression of HIV.

Full Name
beta-2 microglobulin
References
  • Poulik MD, et al. (1979) Beta 2-Microglobulin: methods and clinical applications. CRC Ctit Rev Clin Lab Sci. 10(3): 225-45.
  • Poulik MD, et al. (1975) Beta2-Microglobulins. Contemp Top Mol Immunol. 4: 157-204.
  • Berggard I. (1976) Beta2-Microglobulins: isolation, properties, and distribution. Fed Proc. 35(5): 1167-70.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-Beta-2 microglobulin Antibody Rabbit Polyclonal WB,ELISA,IP 90152-T52
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    Anti-Beta-2 microglobulin Antibody Rabbit Polyclonal ELISA,IHC-P 50957-RP02
    Anti-Beta-2 microglobulin Antibody Mouse Monoclonal FCM,ICC/IF,IF 11976-MM01
    Anti-Beta-2 microglobulin Antibody Rabbit Monoclonal WB,IP 11976-R201
    Anti-Beta-2 microglobulin Antibody (PE) Mouse Monoclonal FCM 11976-MM01-P
    Anti-Beta-2 microglobulin Antibody Rabbit Polyclonal WB,ELISA,IP 11976-RP02
    Anti-Beta-2 microglobulin Antibody Rabbit Monoclonal IHC-P,ICC/IF,IF 11976-R209
    Anti-Beta-2 microglobulin Antibody (FITC) Mouse Monoclonal FCM 11976-MM01-F
    Anti-Beta-2 microglobulin Antibody Mouse Monoclonal ELISA,IHC-P 11976-MM04
    Anti-Beta-2 microglobulin Antibody Rabbit Polyclonal ELISA 11976-RP01
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