Axl Protein & Antibody

Axl receptor tyrosine kinase

Axl Products

Axl Protein, Recombinant

Molecule	Species	Description	Cat. No
Axl	Human	Axl Protein, Recombinant	10279-H08H
Axl	Mouse	Axl/Fc Protein, Recombinant	50126-M03H
Axl	Mouse	Axl Protein, Recombinant	50126-M08H

Axl Antibody

Molecule	Application	Description	Cat. No
Human Axl	WB, ELISA	Axl Antibody, Rabbit PAb	10279-RP01
Human Axl	WB, ELISA	Axl Antibody, Rabbit PAb (Antigen Affinity Purified)	10279-RP02
Mouse Axl	WB, ELISA	Axl Antibody, Rabbit PAb	50126-RP01
Mouse Axl	WB, ELISA	Axl Antibody, Rabbit PAb (Antigen Affinity Purified)	50126-RP02
Human Axl	WB, ELISA	Axl Antibody, Mouse MAb	10279-MM05

Axl cDNA Clone

Molecule	Species	Description	Cat. No
Axl	Human	Homo sapiens Axl transcript variant 1 cDNA Clone(NM_021913.3)	HG10279-M
Axl	Mouse	Mus musculus Axl cDNA Clone	MG50126-M

Axl Alternative Names

AXL, UFO, JTK11 [Homo sapiens]

Axl, Ufo, AI323647, Ark, Tyro7 [Mus musculus]

Axl Related Areas

Enzyme>>Protein Kinase>>Receptor Tyrosine Kinase>>Axl

Signal Transduction>>Protein Kinase>>Receptor Tyrosine Kinase>>Axl

Cancer>>Growth Factor & Receptor>>Receptor Tyrosine Kinase>>Axl

Immunology>>Innate Immunity>>Natural Killer Cell (NK Cell)>>Axl

Axl Background

Axl receptor tyrosine kinase, together with Tyro3 and Mer, constitute the TAM family of receptor tyrosine kinases. In the nervous system, Axl and its ligand Growth-arrest-specific protein 6 (Gas6) are expressed on multiple cell types. Axl functions in dampening the immune response, regulating cytokine secretion, clearing apoptotic cells and debris, and maintaining cell survival. Axl is upregulated in various disease states, such as in the cuprizone toxicity-induced model of demyelination and in multiple sclerosis (MS) lesions, suggesting that it plays a role in disease pathogenesis. Axl expression correlates with poor prognosis in several cancers. Axl mediates multiple oncogenic phenotypes and activation of these RTKs constitutes a mechanism of chemoresistance in a variety of solid tumors. Axl contributes to cell survival, migration, invasion, metastasis and chemosensitivity justify further investigation of Axl as novel therapeutic targets in cancer. The receptor tyrosine kinase AXL is thought to play a role in metastasis. The soluble AXL receptor as a therapeutic candidate agent for treatment of metastatic ovarian cancer. GAS6/AXL targeting as an effective strategy for inhibition of metastatic tumor progression in vivo.

Axl Related Studies

1. Weinger JG, et al. (2011) Loss of the receptor tyrosine kinase Axl leads to enhanced inflammation in the CNS and delayed removal of myelin debris during Experimental Autoimmune Encephalomyelitis. J Neuroinflammation. 8: 49.
2. Linger RM, et al. (2010) Taking aim at Mer and Axl receptor tyrosine kinases as novel therapeutic targets in solid tumors. Expert Opin Ther Targets. 14(10): 1073-90.
3. Cavet ME, et al. (2010) Gas6-Axl pathway: the role of redox-dependent association of Axl with nonmuscle myosin IIB. Hypertension. 56(1): 105-11.
4. Rankin EB, et al. (2010) AXL is an essential factor and therapeutic target for metastatic ovarian cancer. Cancer Res. 70(19): 7570-9.