Autotaxin / ENPP2 Protein & Antibody

Ectonucleotide Pyrophosphatase/Phosphodiesterase 2

Autotaxin / ENPP2 Products

Autotaxin / ENPP2 Protein, Recombinant

Molecule	Species	Description	Cat. No
Autotaxin/ENPP2	Human	Autotaxin/ENPP2 Protein, Recombinant	11308-H07H
Autotaxin/ENPP2	Mouse	Autotaxin/ENPP2 Protein, Recombinant	50663-M07H

Autotaxin / ENPP2 Antibody

Molecule	Application	Description	Cat. No
Mouse Autotaxin/ENPP2	WB, ELISA	Autotaxin / ENPP2 Antibody (Antigen Affinity Purified)	50663-RP02

Autotaxin / ENPP2 cDNA Clone

Molecule	Species	Description	Cat. No
Autotaxin/ENPP2	Human	Homo sapiens Autotaxin/ENPP2 cDNA Clone	HG11308-M
Autotaxin/ENPP2	Mouse	Mouse Autotaxin/ENPP2 cDNA Clone / ORF Clone	MG50663-G

Autotaxin / ENPP2 Related Areas

Enzyme>>Lipid Metabolism Enzymes>>Autotaxin/ENPP2

Lipid Metabolism>>Lipid Metabolism Enzymes>>Autotaxin/ENPP2

Autotaxin / ENPP2 Alternative Names

ENPP2, ATX, ATX-X, AUTOTAXIN, FLJ26803, LysoPLD, NPP2, PD-IALPHA, PDNP2 [Homo sapiens]

Enpp2, ATX, autotaxin, Npps2, PD-Ialpha, Pdnp2 [Mus musculus]

Autotaxin / ENPP2 Background

ENPP2 (Ectonucleotide pyrophosphatase/phosphodiesterase family member 2), also referred as Autotaxin, is a secreted enzyme encoded by the ENPP2 gene. This gene product stimulates the motility of tumor cells, has angiogenic properties, and its expression is upregulated in several kinds of carcinomas. The Autotaxin protein is important for generating the lipid signaling molecule lysophosphatidic acid (LPA), which is a potent mitogen, which facilitates cell proliferation and migration, neurite retraction, platelet aggregation, smooth muscle contraction, actin stress formation and cytokine and chemokine secretion. ATX has been found to catalyze the formation of cyclic phosphatidic acid (cPA), which have antitumor role by antimitogenic regulation of cell cycle, inhibition of cancer invasion and metastasis. LPA receptors and ATX are upregulated in numerous cancer cell types and show expression patterns that correlate with tumor cell invasiveness. Thus, Autotaxin has recently emerged as an attractive target for the development of anti-cancer chemotherapeutics. In addition, Serum ATX activity was found to be enhanced in relation to hepatic fibrosis in chronic liver disease due to hepatitis virus C infection.

Autotaxin / ENPP2 Related Studies

1. Tania M, et al. (2010) Autotaxin: a protein with two faces. Biochem Biophys Res Commun. 401(4): 493-7.
2. Ikeda H, et al. (2009) Significance of serum autotaxin activity in gastrointestinal disease. Rinsho Byori. 57(5): 445-9.
3. Parrill AL, et al. (2008) Autotaxin inhibition: challenges and progress toward novel anti-cancer agents. Anticancer Agents Med Chem. 8(8): 917-23.
4. Pradere J.P, et al. (2007) Secretion and lysophospholipase D activity of autotaxin by adipocytes are controlled by N-glycosylation and signal peptidase. Biochim Biophys Acta. 1771: 93-102.
5. Boucher J, et al. (2005) Potential involvement of adipocyte insulin resistance in obesity-associated up-regulation of adipocyte lysophospholipase D/autotaxin expression. Diabetologia. 48: 569-77.