Anti-ENPP2 Antibody

Cat: 50663-RP02
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Anti-ENPP2 Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-ENPP2 Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Mouse
Specificity
Mouse ENPP2
Immunogen
Recombinant Mouse Autotaxin / ENPP2 protein (Catalog#50663-M07H)
Preparation
Produced in rabbits immunized with purified, recombinant Mouse Autotaxin / ENPP2 (rM Autotaxin / ENPP2; Catalog#50663-M07H; Q9R1E6-1; Ser 49-Ile 862). Autotaxin / ENPP2 specific IgG was purified by Mouse Autotaxin / ENPP2 affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A & Antigen Affinity
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-ENPP2 Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:5000-1:10000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-ENPP2 Antibody Alternative Names
Anti-ATX Antibody;Anti-E-NPP 2 Antibody;Anti-lysoPLD Antibody;Anti-Npps2 Antibody;Anti-PD-Ialpha Antibody;Anti-Pdnp2 Antibody
ENPP2 Background Information

ENPP2 (Ectonucleotide pyrophosphatase/phosphodiesterase family member 2), also referred as Autotaxin, is a secreted enzyme encoded by the ENPP2 gene. This gene product stimulates the motility of tumor cells, has angiogenic properties, and its expression is upregulated in several kinds of carcinomas. The Autotaxin protein is important for generating the lipid signaling molecule lysophosphatidic acid (LPA), which is a potent mitogen, which facilitates cell proliferation and migration, neurite retraction, platelet aggregation, smooth muscle contraction, actin stress formation and cytokine and chemokine secretion. ATX has been found to catalyze the formation of cyclic phosphatidic acid (cPA), which have antitumor role by antimitogenic regulation of cell cycle, inhibition of cancer invasion and metastasis. LPA receptors and ATX are upregulated in numerous cancer cell types and show expression patterns that correlate with tumor cell invasiveness. Thus, Autotaxin has recently emerged as an attractive target for the development of anti-cancer chemotherapeutics. In addition, Serum ATX activity was found to be enhanced in relation to hepatic fibrosis in chronic liver disease due to hepatitis virus C infection.

Full Name
ectonucleotide pyrophosphatase/phosphodiesterase 2
References
  • Tania M, et al. (2010) Autotaxin: a protein with two faces. Biochem Biophys Res Commun. 401(4): 493-7.
  • Ikeda H, et al. (2009) Significance of serum autotaxin activity in gastrointestinal disease. Rinsho Byori. 57(5): 445-9.
  • Parrill AL, et al. (2008) Autotaxin inhibition: challenges and progress toward novel anti-cancer agents. Anticancer Agents Med Chem. 8(8): 917-23.
  • Pradere J.P, et al. (2007) Secretion and lysophospholipase D activity of autotaxin by adipocytes are controlled by N-glycosylation and signal peptidase. Biochim Biophys Acta. 1771: 93-102.
  • Boucher J, et al. (2005) Potential involvement of adipocyte insulin resistance in obesity-associated up-regulation of adipocyte lysophospholipase D/autotaxin expression. Diabetologia. 48: 569-77.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-ENPP2 Antibody Rabbit Polyclonal ELISA,IHC-P 90223-T24
    Anti-ENPP2 Antibody Rabbit Polyclonal ELISA 50663-T16
    Anti-ENPP2 Antibody Mouse Monoclonal ELISA 11308-MM13
    Anti-ENPP2 Antibody Rabbit Polyclonal IHC-P 11308-T08
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