Atherosclerosis Therapeutic Targets

Protein Name	Alternative Names	BioChemical Class / Role	Products (Cat NO)
			Protein	Antibody	Gene cDNA clones
Coagulation Factor II	F2RL2, PAR3				HG11505-M
PLA2G2A	MOM1, PLA2, PLA2B, PLA2L, PLA2S, PLAS1, sPLA2				HG11187-M MG50203-M
MMP-9/MMP9	CLG4B, GELB, MANDP2	MMP9, also known as 92-kDa gelatinase B/type IV collagenase, is secreted from neutrophils, macrophages. This enzyme degrades various substrates including gelatin, collagen types IV and V, and elastin. MMP9 is involved in a variety of autoimmune diseases such as systemic lupus erythematosus, rheumatoid arthritis, and multiple sclerosis, and be regarded as a potential therapeutic target.	10327-H08H 10327-HNAE	10327-MM01 10327-MM02 10327-RM04 10327-RM05 10327-RP03 10327-RP06	HG10327-M
PLA2G7	LDL-PLA2, LP-PLA2, PAFAH				HG10848-M
MMP-12/MMP12	HME, MGC138506, MME				HG10266-M
CRP/C-reactive protein	RP11-419N10.4, MGC149895, MGC88244, PTX1				HG11250-M
NFkB1	DKFZp686C01211, EBP-1, KBF1, MGC54151, NF-kappa-B, NF-kappaB, NFKB-p105, NFKB-p50, p105, p50				HG10212-M
CES2	CE-2, CES2A1, PCE-2, iCE				HG10380-M
CES3	UNQ869/PRO1887, ES31, FLJ21736				HG11129-M
CD40L/CD154/TNFSF5	CD40LG, RP3-527F8.3, HIGM1, IGM, IMD3, T-BAM, TRAP, gp39, hCD40L				HG10239-M
MMP-1/MMP1	CLG, CLGN	MMP1, also well known as interstitial collagenase. The mature form of MMP1 structurally consisits of a catalytic N-terminal domain and a C-terminal (hemopexin-like) domain involved in substrate specificity and in binding TIMP (tissue inhibitor of metalloproteinases). Additionally, studies indicated that MMP1 is also involved in the process of HIV infection. It interacts with and cleaves the HIV Tat protein, leading to a decrease in neuronal Tat's mediated neurotoxicity.	10532-H08H		HG10532-M
MMP-10/MMP10	SL-2, STMY2				HG10249-M
MMP-14/MMP14	MMP-X1, MT1-MMP, MTMMP1				HG10741-M
MMP-2/MMP2	CLG4, CLG4A, MMP-II, MONA, TBE-1	It is a secreted protein which belongs to the peptidase M10A family. MMP-2 is ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, atherosclerotic plaque rupture, as well as degrading extracellular matrix proteins.	10082-HNAH		HG10082-M
MMP-3/MMP3	CHDS6, MGC126102, MGC126103, MGC126104, MMP-3, SL-1, STMY, STMY1, STR1				HG10467-M
MMP-7/MMP7	MPSL1, PUMP-1	MMP7, also referred to as matrilysin, is the smallest member of the MMP family and differs from other MMP members in that it lacks the C-terminal hemopexin-like domain. This enzyme serves essential functions in both innate defense and wound healing, and appears to be one of the most important MMPs in human colon cancers. In addition, matrilysin is also identified as a mediator of pulmonary fibrosis and a potential therapeutic target.	10277-H01H		HG10277-M
MMP-8/MMP8	CLG1, HNC, PMNL-CL	It is a member of the peptidase M10A family. MMP-8 may affect the metastatic behaviour of breast cancer cells through protection against lymph node metastasis, underlining the importance of anti-target identification in drug development.	10254-H08H		HG10254-M
SCARB1	CD36L1, CLA-1, CLA1, MGC138242, SR-BI, SRB1	Scavenger receptor class B is a member of the scavenger receptor family. It binds high density lipoproteins (LDL) and mediates selective cholesterol uptake by a mechanism distinct from the LDL pathway. As is a key component in the reverse cholesterol transport pathway, it also plays an important role in lipid metabolism. Accordingly, it may serve as a useful marker that predicts variation in baseline lipid levels, postprandial lipid response, and response to fenofibrate intervention.	11069-H03H 11069-H08H 50317-M03H		HG11069-M MG50317-M
Coagulation Factor III/Tissue Factor/CD142	F3, FLJ17960, TF, TFA	It is a single-pass type I membrane protein which belongs to the tissue factor family. Tissue factor is the protein that activates the blood clotting system by binding to, and activating, the plasma serine protease, factor VIIa, following vascular injury. Because of its essential role in hemostasis, Tissue factor plays a role in pathology associated with hemostasis, triggering the coagulation system in many thrombotic diseases and the coagulopathies associated with sepsis	50413-M08H		MG50413-M
ECE1	RP3-329E20.1, ECE				HG10887-M
ECE2	hCG_2022032, KIAA0604, MGC17664, MGC2408, MGC78487	ECE2, a type II transmembrane proteins with a short cytoplasmic tail and a large ectodomain, which is a homologous enzyme that shares catalytic activity with ECE1with 59% amino acid identity, and together are zinc protease members of the neprilysin (NEP) family. It is the one of the most significant enzymes implicated in β-amyloid clearance.	10207-H01H		HG10207-M
CCL2/MCP-1	GDCF-2, HC11, HSMCR30, MCAF, MCP-1, MCP1, MGC9434, SCYA2, SMC-CF				HG10134-M
FABP4/ALBP/A-FABP	aP2	FABP4 is a cytoplasm protein which belongs to the calycin superfamily and Fatty-acid binding protein (FABP) family, which is an adipokine regulating systemic insulin sensitivity, lipid and glucose metabolism. In addition, it s a strong plasma marker of metabolic disturbances in HIV-infected patients, and therefore, could serve to guide therapeutic intervention in this group of patients.	50652-M08H
CAV1	BSCL3, CGL3, MSTP085, VIP21				HG11440-M
PTPN2	PTN2, PTPT, TC-PTP, TCELLPTP, TCPTP				HG10570-M
PTPN1	PTP1B				HG10304-M
PTPN2	PTN2, PTPT, TC-PTP, TCELLPTP, TCPTP				HG10571-M
PTPN6	HCP, HCPH, HPTP1C, PTP-1C, SH-PTP1, SHP-1, SHP-1L, SHP1				HG10884-M