Asthma Therapeutic Targets

Protein Name	Alternative Names	BioChemical Class / Role	Products (Cat NO)
			Protein	Antibody	Gene cDNA clones
ADRB2					HG10378-M
ELA2					MG50204-M
Integrin alpha 4/CD49d	ITGA4.IA4, MGC90518	CD49d is an integrin alpha subunit. It makes up half of the α4β1 lymphocyte homing receptor. Integrins alpha-4/beta-1 (VLA-4) and alpha-4/beta-7 are receptors for fibronectin. On activated endothelial cells integrin VLA-4 triggers homotypic aggregation for most VLA-4-positive leukocyte cell lines. It may also participate in cytolytic T-cell interactions with target cells.			MG50049-M
PARP-1/PARP	PARP1, ADPRT, ADPRT1, RP11-125A15.2, PPOL, pADPRT-1	Poly (ADP-ribose) polymerase 1(PRAP1), also known as NAD(+) ADP-ribosyltransferase 1(ADPRT), is a chromatin-associated enzyme which modifies various nuclear proteins by poly(ADP-ribosyl)ation. PARP1 is critical for a wide range of processes, including DNA repair, regulation of chromosome structure, transcriptional regulation, mitosis and apoptosis. It is involved in differentiation, proliferation, and tumor transformation. Additionally, it may participate in the pathophysiology of type I diabetes.	11040-H08B		HG11040-M
TNF-alpha	TNF, TNFA, TNFSF2, DADB-70P7.1, DIF	TNF-alpha (Tumor necrosis factor alpha ), also known as TNF, TNFA or TNFSF2, is the prototypic cytokine of the TNF superfamily, and is a multifunctional molecule involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. TNF-alpha is involved in fighting against the tumorigenesis, thus, is regarded as a molecular insight in cancer treatment.	10602-HNA 50349-MNAE	10602-MM01 10602-MM02, 10602-RP03	HG10602-M MG50349-M
CXCR2/ CD182/ CD128b/IL-8RB					HG10788-M
E-Selectin/CD62e	ELAM-1, ELAM1, ELAM, SELE, RP1-117P20.2, ESEL, LECAM2	E-selectin, also known as endothelial leukocyte adhesion molecule-1 (ELAM-1) and CD62e, is an inducible adhesion molecule. E-selectin supports rolling and stable arrest of leukocytes on activated vascular endothelium, and furthermore, it was indicated that it can also transduce an activating stimulus via the MAPK cascade into the endothelial cell during leukocyte adhesion. In addition, this adhesion molecule appears to be involved in the pathogenesis of atherosclerosis.	10335-H03H, 10335-H08H		HG10335-M
ICAM-1/CD54	ICAM1, BB2, CD54, P3.58	ICAM-1 (Inter-Cellular Adhesion Molecule 1), also known as CD54, is a type of intercellular adhesion molecule constitutely present in low concentrations in the membranes of leukocytes and endothelial cells. ICAM-1 is well known for its importance in stabilizing cell-cell interactions and facilitating leukocyte endothelial transmigration. It also becomes known for its affinity for Plasmodium falciparum-infected erythrocytes (PFIE), providing more of a role in infectious disease.	10346-H03H 10346-H08H 10346-HCCH		HG10346-M
IL-13	ALRH, BHR1, IL13, MGC116786, MGC116788, MGC116789, P600	IL-13, a single-chain glycosylated polypeptide, is critical in regulating inflammatory and immune responses. IL-13 is associated primarily with the pathophysiology of atopic respiratory diseases such as allergic asthma. In addition, studies have identified IL13 expression as a common feature of cHL (classical Hodgkin lymphoma).	10369-H01H 11057-CNAH	10369-MM01 10369-MM02	HG10369-M MG50225-M 11057-M
IL-4R/CD124	IL4RA	IL-4R is a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE antibody  production in B cells. Soluble IL4R (sIL4R) inhibits IL4-mediated cell proliferation and IL5 up-regulation by T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitus, asthma, or eczema.	10402-H08H	10402-RP01	HG10402-M
Syk					HG10540-M