Arylsulfatase A Protein & Antibody (ARSA)

Arylsulfatase A Products

Arylsulfatase A Protein, Recombinant

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
Arylsulfatase A	Human	Arylsulfatase A Protein, Recombinant	10449-H08H
Arylsulfatase A	Mouse	Arylsulfatase A  Protein, Recombinant	50018-M08H

  10449-H08H:  The specific activity is > 50 pmoles / min / µg. Measured by its ability to hydrolyze the substrate 4-Nitrocatechol Sulfate (PNCS).

  50018-M08H:  The specific activity is > 100 pmoles / min / µg. Measured by its ability to hydrolyze the substrate 4-Nitrocatechol Sulfate (PNCS).

Arylsulfatase A Antibody

Molecule	Application	Description //For Detailed Info. and Price------CLICK!	Cat. No
Human Arylsulfatase A	WB, ELISA	Arylsulfatase A Antibody, Rabbit PAb	10449-RP01
Human Arylsulfatase A	WB, ELISA	Arylsulfatase A Antibody, Rabbit PAb (Antigen Affinity Purified)	10449-RP02
Human Arylsulfatase A	WB	Arylsulfatase A / ARSA Antibody	10449-R001
Human Arylsulfatase A	ELISA	Arylsulfatase A / ARSA Antibody	10449-R012
Mouse Arylsulfatase A	WB, ELISA	Arylsulfatase A Antibody, Rabbit PAb	50018-RP01
Mouse Arylsulfatase A	WB, ELISA	Arylsulfatase A Antibody, Rabbit PAb (Antigen Affinity Purified)	50018-RP02
Mouse Arylsulfatase A	WB, ELISA	Arylsulfatase A / ARSA Antibody	50018-R001

Arylsulfatase A cDNA Clone

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
Arylsulfatase A	Human	Homo sapiens Arylsulfatase A cDNA Clone(NM_000487.4)	HG10449-M
Arylsulfatase A	Mouse	Mus musculus Arylsulfatase A cDNA Clone	MG50018-M

Arylsulfatase A Related Areas

Enzyme>>Sulfatase & Sulfotransferase>>Arylsulfatase A/ARSA

Enzyme>>Carbohydrate Metabolism Enzymes>>Arylsulfatase A/ARSA

Immunology>>Innate Immunity>>Lysosomal Enzyme>>Arylsulfatase A/ARSA

Arylsulfatase A Alternative Names

Arylsulfatase A, ARSA, MLD [Homo sapiens]

Arylsulfatase A, Arsa, AS-A, ASA, AW212749, As-2, As2, C230037L18Rik, TISP73 [Mus musculus]

Arylsulfatase A Background

Arylsulfatase A (ARSA) is synthesized as a 52KDa lysosomal enzyme. It is a member of the sulfatase family that is required for the lysosomal degradation of cerebroside-3-sulfate, a sphingolipid sulfate ester and a major constituent of the myelin sheet. Arylsulfatase A is activated by a required co- or posttranslational modification with the oxidation of cysteine to formylglycine. Metachromatic leukodystrophy (MLD) is a lysosomal storage disease in the central and peripheral nervous systems with severe and progressive neurological symptoms caused by the deficiency of Arylsulfatase A. Deficiency of this enzyme is also found in apparently healthy individuals, a condition for which the term pseudodeficiency is introduced. ARSA forms dimers after receiving three N-linked oligosaccharides in the endoplasmic reticulum, and then the dimers are transported to the Golgi where they receive mannose 6-phosphate recognition markers. And thus, ARSA is transported and delivered to dense lysosomes in a mannose 6-phosphate receptor-dependent manner. It has been shown that within the lysosomes, the ARSA dimers can oligomerize to an octamer in a pH-dependent manner. The ARSA deficiency leads to metachromatic leucodystrophy (MLD), a lysosomal storage disorder associated with severe and progressive demyelination in he central and peripheral nervous system. Additionally, the serum level of arylsulfatase A might be helpful in diagnosis of lung and central nervous system cancer.

Arylsulfatase A Related Studies

1. Laidler PM. (1991) Arylsulfatase A--physico-chemical properties and the use of enzyme radioimmunoassay in medical diagnosis Folia Med Cracov. 32(3-4): 149-68.
2. Jean S, et al. (2006) Ethanol decreases rat hepatic arylsulfatase A activity levels. Alcohol Clin Exp Res. 30(11): 1950-5.