ARSA (Protein|Antibody|cDNA Clone|ELISA Kit)

All ARSA reagents are produced in house and quality controlled, including 7 ARSA Antibody, 26 ARSA Gene, 1 ARSA IPKit, 2 ARSA Lysate, 2 ARSA Protein, 2 ARSA qPCR. All ARSA reagents are ready to use.

Recombinant ARSA proteins are expressed by HEK293 Cells with fusion tags as C-His.

ARSAantibodies are validated with different applications, which are ELISA, WB, IP.

ARSAcDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each ARSA of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.

ARSA Protein (2)

Species

ARSA Protein, Mouse, Recombinant (His Tag)

50018-M08H

Expression host: HEK293 Cells

Mouse Arylsulfatase A / ARSA Protein 11303

ARSA Protein, Human, Recombinant (His Tag)

10449-H08H

Expression host: HEK293 Cells

Human Arylsulfatase A / ARSA Protein 8822
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ARSA Antibody (7)

Application Clonality
Host

Anti-ARSA Antibody

10449-RP02

Application: WB,ELISA

Clonality: PAb

Human Arylsulfatase A / ARSA Western blot (WB) 13221

Anti-ARSA Antibody

50018-RP01

Application: ELISA

Clonality: PAb

Anti-ARSA Antibody

10449-RP01

Application: ELISA

Clonality: PAb

Anti-ARSA Antibody

50018-RP02

Application: WB,ELISA,IP

Clonality: PAb

Mouse Arylsulfatase A / ARSA Immunoprecipitation(IP) 8216

Anti-ARSA Antibody

10449-R001

Application: WB

Clonality: MAb

Human Arylsulfatase A / ARSA Western blot (WB) 13220

Anti-ARSA Antibody

50018-R001

Application: ELISA

Clonality: MAb

Anti-ARSA Antibody

10449-R012

Application: ELISA

Clonality: MAb

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ARSA cDNA Clone (26)

Human
Mouse

ARSA qPCR Primer (2)

ARSA IP Kit (1)

ARSA Lysate (2)

Arylsulfatase A (ARSA) is synthesized as a 52KDa lysosomal enzyme. It is a member of the sulfatase family that is required for the lysosomal degradation of cerebroside-3-sulfate, a sphingolipid sulfate ester and a major constituent of the myelin sheet. Arylsulfatase A is activated by a required co- or posttranslational modification with the oxidation of cysteine to formylglycine. Metachromatic leukodystrophy (MLD) is a lysosomal storage disease in the central and peripheral nervous systems with severe and progressive neurological symptoms caused by the deficiency of Arylsulfatase A. Deficiency of this enzyme is also found in apparently healthy individuals, a condition for which the term pseudodeficiency is introduced. ARSA forms dimers after receiving three N-linked oligosaccharides in the endoplasmic reticulum, and then the dimers are transported to the Golgi where they receive mannose 6-phosphate recognition markers. And thus, ARSA is transported and delivered to dense lysosomes in a mannose 6-phosphate receptor-dependent manner. It has been shown that within the lysosomes, the ARSA dimers can oligomerize to an octamer in a pH-dependent manner. The ARSA deficiency leads to metachromatic leucodystrophy (MLD), a lysosomal storage disorder associated with severe and progressive demyelination in he central and peripheral nervous system. Additionally, the serum level of arylsulfatase A might be helpful in diagnosis of lung and central nervous system cancer.

Protein
Antibody
Gene
qPCR
IPKit
Lysate
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