Anti-ARSA Antibody

Cat: 10449-R012
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Anti-ARSA Antibody (Rabbit Monoclonal antibody) General Information
Product name
Anti-ARSA Antibody
Validated applications
Species reactivity
Reacts with: Human
Human ARSA
Has cross-reactivity in ELISA with Mouse ARSA
Recombinant Human Arylsulfatase A / ARSA protein (Catalog#10449-H08H)
This antibody was obtained from a rabbit immunized with purified, recombinant Human Arylsulfatase A / ARSA (rh Arylsulfatase A / ARSA; Catalog#10449-H08H; NP_000478.2; Met 1-Ala 507).
Monoclonal Rabbit IgG Clone #012
Protein A
0.2 μm filtered solution in PBS
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-ARSA Antibody (Rabbit Monoclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:1000-1:2000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-ARSA Antibody Alternative Names
Anti-MLD Antibody
ARSA Background Information

Arylsulfatase A (ARSA) is synthesized as a 52KDa lysosomal enzyme. It is a member of the sulfatase family that is required for the lysosomal degradation of cerebroside-3-sulfate, a sphingolipid sulfate ester and a major constituent of the myelin sheet. Arylsulfatase A is activated by a required co- or posttranslational modification with the oxidation of cysteine to formylglycine. Metachromatic leukodystrophy (MLD) is a lysosomal storage disease in the central and peripheral nervous systems with severe and progressive neurological symptoms caused by the deficiency of Arylsulfatase A. Deficiency of this enzyme is also found in apparently healthy individuals, a condition for which the term pseudodeficiency is introduced. ARSA forms dimers after receiving three N-linked oligosaccharides in the endoplasmic reticulum, and then the dimers are transported to the Golgi where they receive mannose 6-phosphate recognition markers. And thus, ARSA is transported and delivered to dense lysosomes in a mannose 6-phosphate receptor-dependent manner. It has been shown that within the lysosomes, the ARSA dimers can oligomerize to an octamer in a pH-dependent manner. The ARSA deficiency leads to metachromatic leucodystrophy (MLD), a lysosomal storage disorder associated with severe and progressive demyelination in he central and peripheral nervous system. Additionally, the serum level of arylsulfatase A might be helpful in diagnosis of lung and central nervous system cancer.

Full Name
arylsulfatase A
  • Laidler PM. (1991) Arylsulfatase A--physico-chemical properties and the use of enzyme radioimmunoassay in medical diagnosis Folia Med Cracov. 32(3-4): 149-68.
  • Jean S, et al. (2006) Ethanol decreases rat hepatic arylsulfatase A activity levels. Alcohol Clin Exp Res. 30(11): 1950-5.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-ARSA Antibody Rabbit Polyclonal WB,ELISA,IP 50018-RP02
    Anti-ARSA Antibody Rabbit Polyclonal ELISA 50018-RP01
    Anti-ARSA Antibody Rabbit Monoclonal ELISA 50018-R001
    Anti-ARSA Antibody Rabbit Polyclonal ELISA 10449-RP01
    Anti-ARSA Antibody Rabbit Polyclonal WB,ELISA 10449-RP02
    Anti-ARSA Antibody Rabbit Monoclonal WB 10449-R001
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