Arthritis Therapeutic Targets

Protein Name	Alternative Names	BioChemical Class / Role	Products (Cat NO)
			Protein	Antibody	Gene cDNA clones
CD16a	RP11-5K23.1, CD16, CD16A, FCG3, FCGR3, FCGRIII, FCR-10, FCRIII, FCRIIIA, IGFR3	In human, CD16 is expressed as two distinct forms (CD16a and CD16b) encoded by two different highly homologous genes in a cell type-specific manner. CD16a has an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain and delivers an activation signal in the immune responses. As an inflammatory mediator, CD16a receptor is involved in phagocytosis, secretion of enzymes, antibody-dependent cellular cytotoxicity (ADCC), mast cell degranulation, and clearance of immune complexes. Aberrant expression or mutations in this gene are implicated in susceptibility to recurrent viral infections, systemic lupus erythematosus, and alloimmune neonatal neutropenia.	10389-H08H	10389-MM01 10389-MM02 10389-MM03	HG10389-M
CD16b	CD16, FCG3, FCGR3,FCGR3B	CD16b is unique in that it is the only Fc receptor linked to the plasma membrane. The GPI-anchored proteins often preferentially localize to DRMs (detergent-resistant membranes) that are rich in sphingolipids and cholesterol and play an important role in signal transduction. CD16b associates with complement receptor 3 (CR3, Mac-1, CD11b/CD18) which can indirectly link CD16b to the actin cytoskeleton.	11046-H08H	11046-RP01	HG11046-M
CD16-2	4833442P21Rik, FcgRIV, FcgammaRIV, Fcgr3a, Fcrl3, Fcgr4	Mouse FCGR4, also referred to as CD16-2, has been proposed to be the mouse homolog of human Fc γ RIIIA because of high sequence homology (60 % aa identity). Although mouse FCGR4 functioned as a low-affinity IgE receptor for all IgE allotypes, ligation of FCGR4 by antigen-IgE(b) immune complexes promotes macrophage-mediated phagocytosis, presentation of antigen to T cells, production of proinflammatory cytokines and the late phase of cutaneous allergic reactions.	50036-M08H	50036-RP01 50036-RP01	MG50036-M
CD80/B7-1	B7, CD28LG, CD28LG1, LAB7	The B-lymphocyte activation antigen B7-1(referred to as B7), also known as CD80, is a member of cell surface immunoglobulin superfamily. As costimulatory ligands, B7-1 which exists predominantly as dimer and the related protein B7-2, interact with the costimulatory receptors CD28 and cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) expressed on T cells, and thus constitute one of the dominant pathways that regulate T cell activation and tolerance, cytokine production, and the generation of CTL. CD80 is thus regarded as promising therapeutic targets for autoimmune diseases and various carcinomas.	10698-H03H 10698-H08H 10698-HCCH		HG10698-M
CD86/B7-2	B70, CD28LG2, LAB72, MGC34413	The B-lymphocyte activation antigen B7-2 (referred to as B70), also known as CD86, is a member of the cell surface immunoglobulin superfamily. Binding of B7-2 with CD28 induces the activation of T cell, whereas CTLA-4 acts as a negative regulator and diminishes the immune responses. CD86 has an important role in chronic hemodialysis, allergic pulmonary inflammation, arthritis, and antiviral responses, and thus is regarded as a promising candidate for immune therapy.	10699-H03H, 10699-H08H, 50068-M03H, 50068-M08H		HG10699-M MG50068-M
Complement C5a	C5a , CPAMD4, FLJ17816, FLJ17822, MGC142298	C5a is a protein fragment released from complement component C5. C5a is an extremely potent proinflammatory mediator, as well as a potent chemotactic factor for neutrophils and other leukocytes. It causes histamine release, increases in vascular permeability, induces several cytokines production from leukocytes, enhances neutrophil-endothelial cell adhesion, and augments the humoral and cell-mediated immune response. Accordingly, the anaphylatoxin C5a is implicated in a variety of diseases such as rheumatoid arthritis, systemic lupus erythematosus, reperfusion injury, Alzheimer's disease, and sepsis.	10604-HNAE		HG10604-M
IL-1R1/CD121a	IL1R1, CD121A, D2S1473, IL-1R-alpha, IL1R, IL1RA, P80	IL-1R1/CD121a is a type â…¡ receptor is a 68 kDa transmembrane protein with a short cytoplamic domain and serves as a decoy for IL-1. As important mediators involved in many immune and inflammatory responses, the agonists IL1A and IL1B bind to IL1R1, leading to the signal transduction and activation of NF-kappa-B.	10126-H02H 10126-H08H	10126-RP01 10126-RP02	HG10126-M
IL-1R2/CD121b	IL1R2, IL-1RII, IL1RB, MGC47725	IL-1R2/CD121b can bind all three forms of IL1 (IL1 alpha, IL1 beta and IL1ra) but does not transmit IL1 signals. In addition to the membrane-bound form, IL1RII also exists as the soluble form, and either acts as a decoy receptor that inhibits IL1 action by blocking the binding of IL1 to the type I receptor complex. It is a potent antagonist of IL1 action, and serves as a potential therapeutic target.	10111-H02H		HG10111-M
IL-6R/CD126	IL6R, IL-6R-1, IL-6R-alpha, IL6RA, MGC104991	The IL6R , also known as CD126, is a type I transmembrane cytokine receptor and lacks a tyrosine/kinase domain within the cytoplasmic region, unlike other growth factor receptors. Dysregulated production of IL6 and IL6R are implicated in the pathogenesis of several inflammatory diseases and malignancies such as multiple myeloma, rheumatoid arthritis, or osteoporosis, and it has been reported that a humanized anti-IL6R monoclonal antibody is a promising agent applicable to the therapeutic approach for IL6 driven diseases.	10398-H08H 50280-M08H	10398-MM01 10398-RP02, 10398-RP02	HG10398-M MG50280-M
Integrin alpha 4/CD49d	ITGA4.IA4, MGC90518	CD49d is an integrin alpha subunit. It makes up half of the α4β1 lymphocyte homing receptor. Integrins alpha-4/beta-1 (VLA-4) and alpha-4/beta-7 are receptors for fibronectin. On activated endothelial cells integrin VLA-4 triggers homotypic aggregation for most VLA-4-positive leukocyte cell lines. It may also participate in cytolytic T-cell interactions with target cells.			MG50049-M
TNF-alpha	TNF, TNFA, TNFSF2, DADB-70P7.1, DIF	TNF-alpha (Tumor necrosis factor alpha ), also known as TNF, TNFA or TNFSF2, is the prototypic cytokine of the TNF superfamily, and is a multifunctional molecule involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. TNF-alpha is involved in fighting against the tumorigenesis, thus, is regarded as a molecular insight in cancer treatment.	10602-HNAE 50349-MNAE	10602-MM01 10602-MM02 10602-RP03	HG10602-M MG50349-M
VEGF	VEGF-A, RP1-261G23.1, MGC70609, MVCD1, VPF	VEGF(Vascular endothelial growth factor ), also known as vascular permeability factor (VPF) and VEGF-A, is a potent mediator of both angiogenesis and vasculogenesis in the fetus and adult. VEGF-A is important for the formation of blood vessels, such as during development or in pathological conditions.	11066-HNAB		HG10008-M HG10009-M HG10010-M HG11066-M MG50159-M
Cathepsin K	CTSK, RP11-363I22.4, CTS02, CTSO, CTSO1, CTSO2, MGC23107, PKND, PYCD	Cathepsin K is a protease, which is defined by its high specificity for kinins, that is involved in bone resorption. The enzyme's ability to catabolize elastin, collagen, and gelatin  allow it to break down bone and cartilage. It may play an important role in extracellular matrix degradation.			HG10796-M
CD4	L3T4, Ly-4	T-cell surface glycoprotein CD4, also known as T-cell surface antigen T4/Leu-3, is a single-pass type I membrane protein. CD4 interacts directly with MHC class II molecules on the surface of the antigen presenting cell via its extracellular domain. CD4 is a primary receptor used by HIV-1 to gain entry into host T cells. HIV infection leads to a progressive reduction of the number of T cells possessing CD4 receptors.	50134-M08H		HG10400-M MG50134-M
IL12A/IL-12A	P35, IL12A, CLMF, NFSK, NKSF1	Interleukin 12 (IL12), also known as natural killer cell stimulatory factor (NKSF) or cytotoxic lymphocyte maturation factor (CLMF), is a 70 kDa disulfide-linked heterodimeric cytokine composed of a 35-kD subunit P35 and a 40-kD subunit P40, also designated as IL12A and IL12B. IL12A shows significant sequence similarity to IL-6, G-CSF, and exerts biological activities only when the IL12B is co-expressed.	10021-H02H		HG10021-M
IL12B/IL-12B	IL12B, CLMF, CLMF2, NKSF, NKSF2	A large excess of monomeric IL12B is secreted by the cells producing IL12, and exhibits no demonstrable biological activity. Overexpression of IL12B gene has been shown to be associated with the pathogenesis of multiple sclerosis. In addition, studies have revealed that the promoter polymorphism of this gene is implicated in the severity of atopic and non-atopic asthma in children.	10052-H02H 10052-H08H	10052-MM01 10052-RP02 10052-RP03	HG10052-M
IL-6	IL6, BSF2, HGF, HSF, IFNB2	Interleukin 6 (IL-6) is a potent pleiotropic cytokine that regulates cell growth and differentiation of various tissues, and is known particularly for its role in the immune response and acute phase reactions. IL-6 is secreted by T cells and macrophages to stimulate immune response to trauma, especially burns or other tissue damage leading to inflammation. It is also essential for hybridoma growth and is found in many supplemental cloning media such as briclone.	10395-HNAE	10395-MM02 10395-RP01 10395-RP03	HG10395-M MG50136-M
IL-13	ALRH, BHR1, IL13, MGC116786, MGC116788, MGC116789, P600	IL-13, a single-chain glycosylated polypeptide, is critical in regulating inflammatory and immune responses. IL-13 is associated primarily with the pathophysiology of atopic respiratory diseases such as allergic asthma. In addition, studies have identified IL13 expression as a common feature of cHL (classical Hodgkin lymphoma).	10369-H01H 11057-CNAH	10369-MM01 10369-MM02	HG10369-M MG50225-M 11057-M
p38 alpha/MAPK14	p38, CSBP1, CSBP2, Mxi2, PRKM14, PRKM15, RK, CSPB1, SAPK2A, EXIP, RP1-179N16.5	Four alternatively spliced transcript variants of p38 have been reported, p38 alpha (also known as MAPK14) is the best characterized isoform. p38 alpha/MAPK14 is activated following exposure to products of microbial pathogens, physical-chemical stimuli and cytokines. Furthermore, the p38 alpha/MAPK14 has been suggested to play a critical role linking developmental and stress-induced erythropoiesis through regulation of Epo expression.	10081-H08B, 10081-H07B, 10646-HNCB		HG10081-M HG10646-M,
MMP-1/MMP1	CLG, CLGN	MMP1, also well known as interstitial collagenase, is an enzyme expressed by fibroblasts, keratinocytes, endothelial cells, monocytes and macrophages, and can degrade a broad range of substrates, majorly types I, II, III, VII, VIII, and X collagens, as well as casein, gelatin, α-1 antitrypsin, etc. The studies indicated that MMP1 is also involved in the process of HIV infection. It interacts with and cleaves the HIV Tat protein, leading to a decrease in neuronal Tat's mediated neurotoxicity.	10532-H08H		HG10532-M
MMP-2/MMP2					HG10082-M
MMP-3/MMP3					HG10467-M
MMP-9/MMP9	CLG4B, GELB, MANDP2	MMP9, also known as 92-kDa gelatinase B/type IV collagenase, is secreted from neutrophils, macrophages. This enzyme degrades various substrates including gelatin, collagen types IV and V, and elastin. MMP9 is involved in a variety of autoimmune diseases such as systemic lupus erythematosus, rheumatoid arthritis, and multiple sclerosis, and be regarded as a potential therapeutic target.	10327-H08H 10327-HNAE	10327-MM01 10327-MM02 10327-RM04 10327-RM05 10327-RP03 10327-RP06	HG10327-M
MMP-14/MMP14					HG10741-M
Syk					HG10540-M
IL-10	CSIF, TGIF, IL10, IL10A, MGC126450, MGC126451				HG10947-M, MG50245-M
PAF	L5,  PAF,  OEATC1,  NS5ATP9,  OEATC-1,  p15(PAF),  KIAA0101				HG10997-M
TNFR1	CD120a, TNFRSF1A	A type I transmembrane protein which is widely expressed. TNFR1 serves as a receptor for TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha, and is involved in caspases mediating apoptosis. It can also activate the transcription factor NF-kB, and functions as a regulator of inflammation. Germline mutations of the extracellular domains of TNFR1 are found to be associated with the human genetic disorder called periodic fever syndrome.	10872-H03H		HG10872-M
TNFR2	CD120b, TNFRSF1B	A member to the TNF-receptor superfamily. TNFR2 inhibits TNF-alpha action by competing with cell surface receptors in binding TNF-alpha, thereby blocking its biologic effects. Knockout studies in mice suggest a role of TNFR2 in protecting neurons from apoptosis by stimulating antioxidative pathways.	10872-H03H		HG10872-M
LTBR/TNFRSF3	CD18, TNFCR, D12S370, TNFR-RP, TNFR2-RP, LT-BETA-R, TNF-R-III				HG10581-M
OX40/CD134	TNFRSF4, RP5-902P8.3, ACT35, TXGP1L	TNFRSF4 (TNF receptor superfamily member 4), also well known as OX40, CD134, TXGP1L, is a T-cell activation antigen structurally belonging to a lymphocyte-specific subgroup of the nerve growth factor and tumor necrosis factor receptor superfamily. OX40 is a secondary costimulatory molecule, expressed after 24 to 72 hours following activation. Interactions between OX40 and its ligand in vivo are necessary for the differentiation of activated B-cells into highly immunoglobulin-producing cells. OX40 has been implicated in the pathologic  cytokine storm associated with certain viral infections, including the H5N1 bird flu.	10481-H03H		HG10481-M
CD40/TNFRSF5	Bp50, CDW40, MGC9013, p50	CD40, also known as TNFRSF5, is a member of the TNF receptor superfamily which are single transmembrane-spanning glycoproteins, and plays an essential role in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation.	10774-H03H 10774-H08H		HG10774-M
CD95	Fas, APO-1,  TNFRSF6	A member of the TNF receptor superfamily, expressed on the surface of a number of cell types including epithelial cells, hepatocytes, activated mature lymphocytes and tumor cells. CD95 has been reported to be involved in the activation of NF-kappaB, MAPK3/ERK1, MAPK8/JNK, and the alternate pathways for CTL-mediated cytotoxicity. This protein is implicated in the pathogenesis of various malignancies and diseases of the immune system.	10217-H02H		HG10217-M MG50027-M
CD27	TNFRSF7	A member of the TNF receptor superfamily. CD27 binds to CD70, and plays a key role in regulating B-cell activation and antibody production. CD27 signaling leads to the activation of NF-kappaB and MAPK8/JNK. It can also bind to SIVA, which is a proapoptotic protein, and plays an important role in the apoptosis.	10039-H03H 50110-M03H		HG10039-M MG50110-M
CD30/TNFRSF8	KI-1, D1S166E	CD30, also known as TNFRSF8, is a cell membrane protein of the tumor necrosis factor receptor (TNFR) superfamily. It can regulate proliferation of lymphocytes and may also play an important role in human immunodeficiency virus replication.	10777-H03H		HG10777-M
CD137/4-1BB	TNFRSF9, CDw137, ILA, MGC2172	4-1BB (CD137) is a co-stimulatory molecule of the tumor necrosis factor (TNF) receptor superfamily. 4-1BB signaling either by binding to 4-1BBL or by antibody ligation delivers signals for T-cell activation and growth, as well as monocyte proliferation and B-cell survival, and plays an important role in the amplification of T cell-mediated immune responses.In addition, it is a promising candidate for immunotherapy of human cancer.	10041-H03H		HG10041-M
TRAIL R1	TNFRSF10A, CD261	A member of the tumor necrosis factor (TNF) receptor superfamily. TRAILR2 is activated by TNF-related apoptosis inducing ligand (TNFSF10/TRAIL), and transduces cell death signal and induces cell apoptosis.	10408-H03H		HG10465-M
TRAIL R2	TNFRSF10B, CD262	A member of the tumor necrosis factor (TNF) receptor superfamily. TRAILR2 can be activated by TNF-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces apoptosis signal.	10465-H03H, 10465-H08H		HG10113-M
TRAIL R3	TNFRSF10C, CD263, LIT, DCR1, TRID,  TRAILR3, MGC149501, MGC149502				HG10415-M
TRAIL R4	TNFRSF10D,  CD264, DCR2, TRUNDD, TRAILR4	TRAILR4 is a member of the TNF receptor superfamily and is referred to as TNFRSF10D. It shows a unique expression pattern in human tissues and is particularly abundant in fetal liver and adult testis. Accordingly, it is not capable of activating TRAIL-mediated NF-kappaB or apoptosis pathways, and identified as an antiapoptotic receptor.	10413-H03H		HG10413-M
TNFRSF11B/ Osteoprotegerin	OPG, TR1, OCIF, MGC29565				HG10271-M
TNFRSF12	TNFRSF12A, CD266, TWEAKR, FN14				HG10431-M
TACI/TNFRSF13B	CD267, CVID, FLJ39942, MGC133214, MGC39952, TNFRSF14B				MG50130-M
HVEM/TNFRSF14	HVEA, RP3-395M20.6, ATAR, LIGHTR, TR2	HVEM/TNFRSF14 is a member of type I transmembrane protein belonging to the TNF-receptor superfamily. Recent studies have revealed that HVEM is also involved in the unique inhibitory signaling pathway for T cells through activating tyrosine phosphorylation of the immunoreceptor tyrosine-based inhibitory motif (ITIM) in B and T lymphocyte attenuator (BTLA).	10334-H03H 10567-M03H		HG10334-M
TNFRSF17/BCMA	BCM, CD269	TNFRSF17, also known as BCMA, is a member of the superfamily, and is preferentially expressed in mature B lymphocytes. It binds specifically to the tumor necrosis factor (ligand) superfamily, member 13b (TNFSF13B/TALL-1/BAFF), as well as various TNFR-associated factor (TRAF) family members including TRAF1, TRAF2 and TRAF3 adaptor proteins, and thus transduces signals for cell survival and proliferation.	50076-M01H 50076-M03H		HG10620-M MG50076-M
TNFRSF19	TROY	A member of the TNF-receptor superfamily, highly expressed during embryonic development. It is capable of inducing apoptosis by a caspase-independent mechanism, and plays an essential role in embryonic development.	50148-M03H		MG50148-M
RELT/TNFRSF19L	FLJ14993	TNFRSF19L, also known as RELT (Receptor Expressed in Lymphoid Tissues), is a member of the TNF-receptor superfamily. RELT has been shown to exclusively bind the adaptor protein TNF receptor-associated factor 1 (TRAF1). It also activates the NF-kappaB pathway and is capable of stimulating T-cell proliferation in the presence of CD3 signaling, which suggests its regulatory role in immune response.	10530-H03H		HG10530-M
IL-8/CXCL8	LYNAP, NAF, GCP1, GCP-1, LECT, LUCT, MDNCF, MONAP, NAP-1, NAP1	This chemokine is secreted by a variety of cell types including monocyte/macrophages, T cells, neutrophils, fibroblasts, endothelial cells, and various tumor cell lines in response to inflammatory stimuli (IL1, TNF, LPS, etc). It has been shown that IL-8 plays a vital role in angiogenesis which is important for tumorigenesis and metastasis, and accordingly the expression level of IL8 correlates with disease progression in several human carcinomas.	10098-H01H1 10098-H01H2   10098-HNCH1 10098-HNCH2		HG10098-M
NFkB1	KBF1,  EBP-1,  MGC54151,  NFKB-p50,  NFKB-p105,  NF-kappa-B,  DKFZp686C01211				HG10212-M
CD40L/CD154	CD40LG,IGM, IMD3, TRAP, gp39, HIGM1, T-BAM, TNFSF5, hCD40L				HG10239-M
JNK1/MAPK8	JNK, JNK1A2, JNK21B1/2, PRKM8, SAPK1	Mitogen-activated protein kinase 8 (MAPK8), also known as JNK1, is a member of the MAP kinase family. MAPK8 is activated by threonine and tyrosine phosphorylation by either of two dual specificity kinases, MAP2K4 and MAP2K7. MAPK8 is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. In addition, JNK1, together with JNK2, are required for polarized differentiation of T-helper cells into Th1 cells.	10795-H09B		HG10795-M MG50009-M
JNK2/MAPK9	JNK2A, JNK2ALPHA, JNK2B, JNK2BETA, PRKM9, p54aSAPK, SAPK, p54a, NK-55	Mitogen-activated protein kinase 9 (MAPK9), also well known as c-Jun N-terminal kinase (JNK2), is a member of MAP kinase subfamily belonging to the protein kinase superfamily. MAPK9 responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, such as c-Jun and ATF2. It is most closely related to MAPK8, both of which are involved in UV radiation induced apoptosis.	10745-H08B		HG10745-M
JNK3/MAPK10	FLJ12099, FLJ33785, JNK3A, MGC50974, PRKM10, p493F12, p54bSAPK				HG10626-M
MMP-1/MMP1	CLG, CLGN				HG10532-M
MMP-2/MMP2	CLG4, CLG4A, MMP-II, MONA, TBE-1				HG10082-M
MMP-3/MMP3	CHDS6, MGC126102, MGC126103, MGC126104, MMP-3, SL-1, STMY, STMY1, STR1				HG10467-M
MMP-7/MMP7	MPSL1, PUMP-1	MMP7, also referred to as matrilysin, is the smallest member of the MMP family and differs from other MMP members in that it lacks the C-terminal hemopexin-like domain. This enzyme serves essential functions in both innate defense and wound healing, and appears to be one of the most important MMPs in human colon cancers. In addition, matrilysin is also identified as a mediator of pulmonary fibrosis and a potential therapeutic target.	10277-H01H		HG10277-M
MMP-8/MMP8	CLG1, HNC, PMNL-CL				HG10254-M
MMP-9/MMP9	CLG4B, GELB, MANDP2	MMP9, also known as 92-kDa gelatinase B/type IV collagenase, is secreted from neutrophils, macrophages. This enzyme degrades various substrates including gelatin, collagen types IV and V, and elastin. MMP9 is involved in a variety of autoimmune diseases such as systemic lupus erythematosus, rheumatoid arthritis, and multiple sclerosis, and be regarded as a potential therapeutic target.	10327-H08H 10327-HNAE	10327-MM01 10327-MM02 10327-RM04 10327-RM05 10327-RP03 10327-RP06	HG10327-M
MMP-10/MMP10	SL-2, STMY2				HG10249-M
MMP-12/MMP12	HME, MGC138506, MME				HG10266-M
MMP-14/MMP14	MMP-X1,  MTMMP1,  MT1-MMP				HG10741-M
OSM	MGC20461				HG10452-M, MG50112-M
HMGB1/HMG1	SBP-1, HMG3, DKFZp686A04236	HMGB1/HMG1 is a non-histone architectural chromosomal protein ubiquitously present in all vertebrate nuclei and binds double-stranded DNA without sequence specificity. It can also act as a cytokine extracellularlly and regulates monocyte, T cell, dendritic cell activities in inflammatory responses. Once secreted, HMGB1 induces signal transduction through its receptor RAGE and perhaps TLR2 and TLR4. The immune-regulatory function of HMGB1 may lead to being identified as new therapeutic target.	10326-H01H		HG10326-M
bFGF	FGF-2	a member of the fibroblast growth factor (FGF) family appears to be involved in remodeling damaged tissue.  bFGF  is a heparin-binding cationic protein involved in a variety of pathological conditions including angiogenesis and solid tumour growth.	10014-HNAE	10014-RP01 10014-RP02	HG10014-M MG50037-M
ADAMTS4	ADMP-1, ADAMTS-2, ADAMTS-4, KIAA0688				HG11024-M
ADAMTS5	ADMP-2,  ADAMTS11,  FLJ36738				HG10423-M
S100A8	P8, MIF, NIF, CAGA, CFAG, CGLA, L1Ag, MRP8, CP-10, MA387, 60B8AG				HG11138-M MG50228-M
S100A9	MIF, NIF, P14, CAGB, CFAG, CGLB, L1AG, LIAG, MRP14, 60B8AG, MAC387				HG11145-M MG50284-M
S100A12	p6, CAGC, CGRP, MRP6, CAAF1, ENRAGE				HG11143-M
Cathepsin B	CTSB, APPS, CPSB	Cathepsin B is a papain-family cysteine protease that is normally located in lysosomes, and is a member of a superfamily of structurally similar tissue proteinases. Mature cathepsin B has the ability to degrade several extracellular matrix components at both neutral and acidic pH and has been implicated in the progression of several human and rodent tumors progression and arthritis. It is also suggested as a tumor marker.	10483-H08H		HG10483-M MG50084-M
CD69	CLEC2C	CD69, also known as activation inducer molecule(AIM), is a single-pass type II membrane protein. It is involved in lymphocyte proliferation and functions as a signal transmitting receptor in lymphocytes, natural killer (NK) cells, and platelets. CD69 plays a crucial role in the pathogenesis of allergen-induced eosinophilic airway inflammation and hyperresponsiveness and that CD69 could be a possible therapeutic target for asthmatic patients.	11150-H08H		HG11150-M
Carboxypeptidase A1	CPA1, CPA	Carboxypeptidase A1 is secreted as a pancreatic procarboxypeptidase. In contrast to procarboxypeptidase B which was always secreted by the pancreas as a monomer, procarboxypeptidase A occurs as a monomer and/or associated to one or two functionally different proteins, such as zymogen E, and is involved in zymogen inhibition.	10504-H08H		HG10504-M
Carboxypeptidase A2	CPA2	Carboxypeptidase A2 is a secreted pancreatic procarboxy-peptidase, and cleaves the C-terminal amide or ester bond of peptides that have a free C-terminal carboxyl group. The hydrolytic action of CPA2 was identified with a preference towards long substrates with aromatic amino acids in their C-terminal end, particularly tryptophan.	10499-H08H		HG10499-M
Carboxypeptidase A4	CPA4, CPA3				HG10789-M