Anti-Apolipoprotein H Antibody

Cat: 11221-R003
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Anti-Apolipoprotein H Antibody (Rabbit Monoclonal antibody) General Information
Product name
Anti-Apolipoprotein H Antibody
Validated applications
ELISA,IHC-P
Species reactivity
Reacts with: Human
Specificity
Human Apolipoprotein H
Immunogen
Recombinant Human APOH protein (Catalog#11221-H08H)
Preparation
This antibody was obtained from a rabbit immunized with purified, recombinant Human Apolipoprotein H / APOH (rh Apolipoprotein H / APOH; Catalog#11221-H08H; NP_000033.2; Met 1-Cys345).
Source
Monoclonal Rabbit IgG Clone #003
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-Apolipoprotein H Antibody (Rabbit Monoclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:5000-1:10000  
IHC-P 1:100-1:500  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-Apolipoprotein H Antibody (Rabbit Monoclonal antibody) Images
Human Apolipoprotein H/APOH Immunohistochemistry(IHC) 4692
Immunochemical staining of human APOH in human liver with rabbit monoclonal antibody (1:200, formalin-fixed paraffin embedded sections).
Anti-Apolipoprotein H Antibody Alternative Names
Anti-B2G1 Antibody;Anti-B2GP1 Antibody;Anti-BG Antibody
Apolipoprotein H Background Information

Apolipoprotein H (APOH), also known as Beta-2-glycoprotein 1, Activated protein C-binding protein, B2GPI, and B2G1, is a glycoprotein synthesized by liver cells and it is present in the blood associated with plasma lipoproteins. It is an essential cofactor for the binding of certain antiphospholipid antibodies (APA) to anionic phospholipid. APOH binds to various kinds of negatively charged substances such as heparin, phospholipids, and dextran sulfate. APOH may prevent activation of the intrinsic blood coagulation cascade by binding to phospholipids on the surface of damaged cells. APOH appears to completely inhibit serotonin release by the platelets and prevents subsequent waves of the ADP-induced aggregation. The activity of APOH appears to involve the binding of agglutenating, negatively charged compounds, and inhibits agglutenation by the contact activation of the intrinsic blood coagulation pathway. APOH causes a reduction of the prothrombinase binding sites on platelets and reduces the activation caused by collagen when thrombin is present at physiological serum concentrations of APOH suggesting a regulatory role of APOH in coagulation. APOH plasma concentrations are strongly associated to metabolic syndrome alterations and vascular disease in type 2 diabetic and could be considered as a clinical marker of cardiovascular risk. APOH is found on several classes of lipoproteins, and is involved in the activation of lipoprotein lipase in lipid metabolism. This single-chain glycoprotein also has been implicated in several physiologic pathways including coagulation and the production of hypertension, which are related to the pathogenesis of primary cerebral hemorrhage (PICH).

Full Name
apolipoprotein H (beta-2-glycoprotein I)
References
  • Kamboh MI, et al. (1998) Genetics of apolipoprotein H (beta2-glycoprotein I) and anionic phospholipid binding. Lupus. 7 Suppl 2: S10-3.
  • Singh P, et al. (2002) Genetics of apolipoprotein H (beta2-glycoprotein I) polymorphism in India. Ann Hum Biol. 29(3): 247-55.
  • Xia J, et al. (2004) Apolipoprotein H gene polymorphisms and risk of primary cerebral hemorrhage in a Chinese population. Cerebrovasc Dis. 17(2-3): 197-203.
  • Chen Q, et al. (2006) Complete DNA sequence variation in the apolipoprotein H (beta-glycoprotein I) gene and identification of informative SNPs. Ann Hum Genet. 70(Pt 1): 1-11.
  • Leduc MS, et al. (2008) Comprehensive evaluation of apolipoprotein H gene (APOH) variation identifies novel associations with measures of lipid metabolism in GENOA. J Lipid Res. 49(12): 2648-56.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-Apolipoprotein H Antibody Rabbit Polyclonal WB,ELISA 80701-T48
    Anti-Apolipoprotein H Antibody Rabbit Polyclonal ELISA 11221-T16
    Anti-Apolipoprotein H Antibody Mouse Monoclonal ELISA,FCM,ICC/IF,IF 11221-MM06
    Anti-Apolipoprotein H Antibody Rabbit Polyclonal ELISA 11221-RP01
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