Apolipoprotein H / APOH Protein & Antibody

Apolipoprotein H / APOH Protein Products

Apolipoprotein H / APOH Protein, Recombinant

Molecule	Species	Description	Cat. No
Apolipoprotein H/APOH	Human	Apolipoprotein H/APOH Protein, Recombinant	11221-H08H

Apolipoprotein H / APOH Antibody

Molecule	Application	Description	Cat. No
Human Apolipoprotein H/APOH	WB, ELISA	Mouse Monoclonal Antibody	11221-MM06
Human Apolipoprotein H/APOH	WB, ELISA	Rabbit Polyclonal Antibody	11221-RP01
Human Apolipoprotein H/APOH	WB, ELISA	Rabbit Monoclonal Antibody	11221-R003

Apolipoprotein H / APOH cDNA Clone

Molecule	Species	Description	Cat. No
Apolipoprotein H/APOH	Human	Homo sapiens Apolipoprotein H/APOH DNA ORF clone(NM_000042.2)	HG11221-M
Apolipoprotein H/APOH	Mouse	Mouse Apolipoprotein H/APOH cDNA Clone / ORF Clone	MG50928-G

Apolipoprotein H / APOH ELISA Kit

Molecule	Application	Description	Cat. No
Human Apolipoprotein H/APOH	ELISA	Apolipoprotein H/APOH ELISA Kit	SEK11221

Apolipoprotein H / APOH Related Areas

Immunology>>Innate Immunity>>Coagulation>>Apolipoprotein H/APOH

Cardiovascular>>Coagulation>>Apolipoprotein H/APOH

Cardiovascular>>Lipid Metabolism>>Apolipoprotein H/APOH

Apolipoprotein H / APOH Alternative Names

Apolipoprotein H, APOH, B2G1, BG [Homo sapiens]

Apolipoprotein H, Apoh, B2GPI, RP23-261J24.1, beta-2-GPI, beta2-GPI [Mus musculus]

Apolipoprotein H / APOH Background

Apolipoprotein H (APOH), also known as Beta-2-glycoprotein 1, Activated protein C-binding protein, B2GPI, and B2G1, is a glycoprotein synthesized by liver cells and it is present in the blood associated with plasma lipoproteins. It is an essential cofactor for the binding of certain antiphospholipid antibodies (APA) to anionic phospholipid. APOH binds to various kinds of negatively charged substances such as heparin, phospholipids, and dextran sulfate. APOH may prevent activation of the intrinsic blood coagulation cascade by binding to phospholipids on the surface of damaged cells. APOH appears to completely inhibit serotonin release by the platelets and prevents subsequent waves of the ADP-induced aggregation. The activity of APOH appears to involve the binding of agglutenating, negatively charged compounds, and inhibits agglutenation by the contact activation of the intrinsic blood coagulation pathway. APOH causes a reduction of the prothrombinase binding sites on platelets and reduces the activation caused by collagen when thrombin is present at physiological serum concentrations of APOH suggesting a regulatory role of APOH in coagulation. APOH plasma concentrations are strongly associated to metabolic syndrome alterations and vascular disease in type 2 diabetic and could be considered as a clinical marker of cardiovascular risk. APOH is found on several classes of lipoproteins, and is involved in the activation of lipoprotein lipase in lipid metabolism. This single-chain glycoprotein also has been implicated in several physiologic pathways including coagulation and the production of hypertension, which are related to the pathogenesis of primary cerebral hemorrhage (PICH).

Apolipoprotein H / APOH Related Studies

1. Kamboh MI, et al. (1998) Genetics of apolipoprotein H (beta2-glycoprotein I) and anionic phospholipid binding. Lupus. 7 Suppl 2: S10-3.
2. Singh P, et al. (2002) Genetics of apolipoprotein H (beta2-glycoprotein I) polymorphism in India. Ann Hum Biol. 29(3): 247-55.
3. Xia J, et al. (2004) Apolipoprotein H gene polymorphisms and risk of primary cerebral hemorrhage in a Chinese population. Cerebrovasc Dis. 17(2-3): 197-203.
4. Chen Q, et al. (2006) Complete DNA sequence variation in the apolipoprotein H (beta-glycoprotein I) gene and identification of informative SNPs. Ann Hum Genet. 70(Pt 1): 1-11.
5. Leduc MS, et al. (2008) Comprehensive evaluation of apolipoprotein H gene (APOH) variation identifies novel associations with measures of lipid metabolism in GENOA. J Lipid Res. 49(12): 2648-56.