Antithrombin III (Protein|Antibody|cDNA Clone|ELISA Kit)

All Antithrombin III reagents are produced in house and quality controlled, including 4 Antithrombin III Antibody, 41 Antithrombin III Gene, 2 Antithrombin III Lysate, 2 Antithrombin III Protein, 2 Antithrombin III qPCR. All Antithrombin III reagents are ready to use.

Recombinant Antithrombin III proteins are expressed by HEK293 Cells with fusion tags as C-His.

Antithrombin IIIantibodies are validated with different applications, which are WB, ELISA, IP.

Antithrombin IIIcDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each Antithrombin III of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.

Antithrombin III Protein (2)

Species

Antithrombin III Protein, Human, Recombinant (His Tag)

10142-H08H

Expression host: HEK293 Cells

Human Antithrombin III/ATIII Protein 8445

Antithrombin III Protein, Cynomolgus, Recombinant (His Tag)

90042-C08H

Expression host: HEK293 Cells

Cynomolgus Antithrombin III/ATIII Protein 12751
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Antithrombin III Antibody (4)

Application Clonality
Host

Anti-Antithrombin III Antibody

10142-RP02

Application: ELISA

Clonality: PAb

Anti-Antithrombin III Antibody

10142-R023

Application: ELISA

Clonality: MAb

Anti-Antithrombin III Antibody

10142-RP01

Application: ELISA

Clonality: PAb

Anti-Antithrombin III Antibody

10142-T52

Application: WB,ELISA,IP

Clonality: PAb

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Antithrombin III cDNA Clone (41)

Rat
Human
Mouse

Antithrombin III qPCR Primer (2)

Antithrombin III Lysate (2)

SerpinC1, also known as antithrombin III (AT III), is a member of the serpin superfamily of serine protease inhibitors, and has been found to be a marker for disseminated intravascular coagulation (DIC) and to be of prognostic significance in septic patients. SerpinC1 synthesized in the liver is the principal plasma serpin of blood coagulation proteases and inhibits thrombin and other factors such as Xa by the formation of covalently linked complexes. Thus it is one of the most important coagulation inhibitors and the fundamental enzyme for the therapeutical action of heparin. In common with SerpinA5 and D1, the inhibitory activity of SerpinC1 undergoes a dramatic increase in the presence of heparin and other glycosaminoglycans. ATIII mediates the promotion of prostaglandin release, an inhibitor of leucocyte activation and downregulator of many proinflammatory cytokines. Antithrombin III exerts anti-inflammatory properties in addition to its anti-coagulative mechanisms. In animal models of sepsis, ATIII affected cytokine plasma concentrations with a decrease of pro-inflammatory cytokines. The deficiency or functional abnormality of ATIII may result in an increased risk of thromboembolic disease, such as deep vein thrombosis and pulmonary embolism. In addition, it has been reported that SerpinC1 can alter or influence inflammatory processes via inhibition of NF-κB activation or actin polymerization.

Protein
Antibody
Gene
qPCR
Lysate
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