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> Antithrombin III / ATIII Protein & Antibody (SerpinC1) Antithrombin III / ATIII Protein & Antibody (SerpinC1)
Serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 1
Antithrombin III / ATIII Products
Antithrombin III / ATIII Protein, Recombinant
| Molecule | Species | Description //For Detailed Info. and Price------CLICK! | Cat. No |
| Antithrombin III/ATIII/SerpinC1 |
Cynomolgus |
SerpinC1 / AntithrombinIII Protein, Recombinant | 90042-C08H |
Antithrombin III / ATIII Antibody
| Molecule | Application | Description //For Detailed Info. and Price------CLICK! | Cat. No |
| Human Antithrombin III/ATIII/SerpinC1 |
WB, ELISA | Rabbit Polyclonal Antibody | 10142-RP01 |
| Human Antithrombin III/ATIII/SerpinC1 |
WB, ELISA | Rabbit Polyclonal Antibody (Antigen Affinity Purified) | 10142-RP02 |
| Human Antithrombin III/ATIII/SerpinC1 |
WB, ELISA | Rabbit Monoclonal Antibody | 10142-R023 |
Antithrombin III / ATIII cDNA Clone
| Molecule | Species | Description //For Detailed Info. and Price------CLICK! | Cat. No |
| Antithrombin III/ATIII/SerpinC1 | Human | Homo sapiens Antithrombin III/ATIII/SerpinC1 cDNA Clone(NM_000488.2) | HG10142-M |
Antithrombin III / ATIII Related Areas
Enzyme>>Protease & Regulator>>Serine Protease & Regulator>>Serpin Superfamily>>Antithrombin III/ATIII/SerpinC1
Immunology>>Innate Immunity>>Coagulation>>Antithrombin III/ATIII/SerpinC1
Cardiovascular>>Coagulation>>Antithrombin III/ATIII/SerpinC1
Antithrombin III / ATIII Alternative Names
Antithrombin III, ATIII, AT3, SERPINC1, MGC22579 [Homo sapiens]
Antithrombin III, ATIII, At-3, At3, Serpinc1, AI114908 [Mus musculus]
Antithrombin III / ATIII Related Products
Protein Products
Antibody Products
cDNA Clone Products
Antithrombin III / ATIII Background
SerpinC1, also known as antithrombin III (AT III), is a member of the serpin superfamily of serine protease inhibitors, and has been found to be a marker for disseminated intravascular coagulation (DIC) and to be of prognostic significance in septic patients. SerpinC1 synthesized in the liver is the principal plasma serpin of blood coagulation proteases and inhibits thrombin and other factors such as Xa by the formation of covalently linked complexes. Thus it is one of the most important coagulation inhibitors and the fundamental enzyme for the therapeutical action of heparin. In common with SerpinA5 and D1, the inhibitory activity of SerpinC1 undergoes a dramatic increase in the presence of heparin and other glycosaminoglycans. ATIII mediates the promotion of prostaglandin release, an inhibitor of leucocyte activation and downregulator of many proinflammatory cytokines. Antithrombin III exerts anti-inflammatory properties in addition to its anti-coagulative mechanisms. In animal models of sepsis, ATIII affected cytokine plasma concentrations with a decrease of pro-inflammatory cytokines. The deficiency or functional abnormality of ATIII may result in an increased risk of thromboembolic disease, such as deep vein thrombosis and pulmonary embolism. In addition, it has been reported that SerpinC1 can alter or influence inflammatory processes via inhibition of NF-κB activation or actin polymerization.
Antithrombin III / ATIII Related Studies
- de Sousa JC, et al. (1991) Antithrombin III. Physiologic, physiopathologic and laboratory aspects. Rev Port Cardiol. 10(9): 693-9.
- Totzke G, et al. (2001) Antithrombin III enhances inducible nitric oxide synthase gene expression in vascular smooth muscle cells. Cell Immunol. 208(1): 1-8.
- Ostermann H. (2002) Antithrombin III in Sepsis. New evidences and open questions. Minerva Anestesiol. 68(5): 445-8.
- Caglikulekci M, et al. (2004) Effect of antithrombin-III (AT-III) on intestinal epithelium changes related to obstructive icterus: experimental study in rats. Ann Chir. 129(5): 273-7.
