> Antibody > Rabbit PAb Antibody > Anti-mouse SLAMF7 / CRACC antibody (Antigen Affinity Purified) Anti-mouse SLAMF7 / CRACC antibody (Antigen Affinity Purified)
| Catalog | Size (Price) | Quantity | In Stock | Operation | Other Information |
| 50201-RP02 |
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Mouse SLAM Family Member 7 Antibody ( Antigen Affinity Purified )
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Order or Inquire for SLAMF7 Antibody product |  |
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Detection limit is 0.5 ng/lane in WB |
SLAMF7 / CRACC Antibody Product Information
| Immunogen : |
Recombinant mouse SLAMF7 protein ( Catalog#50201-M08H ) |
| Antibody Type : | Rabbit Polyclonal Antibody ( Antibody Purification Platform ) |
| Ig Type : |
Rabbit IgG |
| Formulation : | 0.2 μm filtered solution in PBS with 5% trehalose |
| Preparation : |
Produced in rabbits immunized with purified, human cell-derived, recombinant mouse SLAMF7 extracellular domain ( rM SLAMF7 ; Catalog#50201-M08H ; NP_653122.2 ; Met 1-Gly 224 ). SLAMF7 specific IgG was purified by mouse SLAMF7 affinity chromatography. |
SLAMF7 / CRACC Antibody Usage Guide
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Specificity : |
Mouse SLAMF7 / CRACC |
| Western blot : | This antibody can be used at 0.1 - 0.2 μg/mL with the appropriate secondary reagents to detect mouse SLAMF7 in WB. Using a DAB detection system, the detection limit for mouse SLAMF7 is approximately 2 ng/lane under non-reducing conditions and 0.5 ng/lane under reducing conditions |
| Storage : | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles. |
SLAMF7 / CRACC Antibody Related Products & Topics
Related Areas:
Immunology>>Adaptive Immunity>>Costimulation & Costimulatory Molecule>>CRACC/SLAMF7
Immunology>>Innate Immunity>>Natural Killer Cell (NK Cell)>>CRACC/SLAMF7
Immunology>>Cluster of Differentiation>>B Cell CD Antigen>>CRACC/SLAMF7/CD319
Immunology>>Cluster of Differentiation>>Monocyte/Macrophage CD Antigen>>Macrophage Markers>>CRACC/SLAMF7/CD319
Proteins:
| Molecule | Species | Description //For Detailed Info.------CLICK! | Cat No | Size/Price |
| CRACC/SLAMF7 | Human | CRACC/SLAMF7 Protein, Recombinant | 11691-H08H | 100µg($290) ; Order |
| CRACC/SLAMF7 | Mouse | CRACC/SLAMF7 Protein, Recombinant | 50201-M08H | 100µg($290) ; Order |
Antibodies:
| Molecule | Application | Description //For Detailed Info.------CLICK! | Cat No | Size/Price |
| Mouse CRACC/SLAM7 |
WB, ELISA | Rabbit Polyclonal Antibody | 50201-RP01 | Order |
| Mouse CRACC/SLAM7 |
WB, ELISA | Rabbit Polyclonal Antibody (Antigen Affinity Purified) | 50201-RP02 | 100µg($250); Order |
SLAMF7 / CRACC Antibody Background
Mouse SLAM family member 7, also known as CRACC, SLAMF7, CD319, CD2-like receptor-activating cytotoxic cells, and CS1, is a single-pass type I membrane protein and a member of the CD2 family of cell surface receptors. SLAMF7 is expressed in NK cells, activated B-cells, NK-cell line but not in promyelocytic, B- cell lines, or T-cell lines. The cytoplasmic domain of SLAMF7 contains immunoreceptor tyrosine-based switch motifs (ITSM), which enables to recruite signaling lymphocyte activation molecule (SLAM)-associated protein (SAP/ SH2D1A). SLAMF7 may play a role in the regulation of B lymphocyte proliferation during immune responses. SLAMF7 is implicated in the activation of NK cell-mediated cytotoxicity. SLAMF7 positively regulated natural killer cell functions by a mechanism dependent on the adaptor EAT-2 but not the related adaptor SAP. In the absence of EAT-2, SLAMF7 potently inhibited natural killer cell function. SLAMF7 was also inhibitory in T cells, which are typically devoid of EAT-2. Thus, SLAMF7 can exert activating or inhibitory influences on cells of the immune system depending on cellular context and the availability of effector proteins.
References
- Lee, JK. et al., 2004, Eur J Immunol. 34 (10): 2791-9.
- Stark, S. et al., 2006, Int Immunol 18 (2): 241-7.
- Lee, JK. et al., 2007, J Immunol. 179 (7): 4672-8.
- Cruz-Munoz, ME. et al., 2009, Nat Immunol. 10 (3): 297-305.
