Anti-human HAVCR1 / TIM1 / KIM1 antibody

Catalog	Size (Price)	Quantity	In Stock	Operation	Other Information
11051-MM06	200µg ($95) 500µg ($195)		YES
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Hepatitis A Virus Cellular Receptor 1 Antibody

		Order or Inquire for KIM1 Antibody product
		Detection limit is 8 ng/lane in WB

HAVCR1 / TIM1 / KIM1 Antibody Product Information

Immunogen :	Recombinant human HAVCR1 protein ( Catalog#11051-H08H1 )
Antibody Type :	Mouse Monoclonal Antibody ( Mouse mAb Service Platform )
Clone ID :	12B1C8H3
Ig Type :	Mouse IgG1
Formulation :	0.2 μm filtered solution in PBS with 5% trehalose
Preparation :	This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, human cell-derived, recombinant human HAVCR1 ( rh HAVCR1 ; Catalog#11051-H08H1 ; NP_002412.1 ; Met 1- Val 135 ). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.

HAVCR1 / TIM1 / KIM1 Antibody Usage Guide

Specificity :	Human HAVCR1 / TIM1 / KIM1
	No cross-reactivity in WB and ELISA with Rat KIM1 / HAVCR1 / TIM1 Mouse KIM1 / HAVCR1 / TIM1 Canine KIM1 / HAVCR1 / TIM1
Western blot ：	This antibody can be used at 1 - 2 μg/mL with the appropriate secondary reagents to detect human KIM1 in WB. Using a DAB detection system, the detection limit for human KIM1 is approximately 100 ng/lane under non-reducing conditions and 8 ng/lane under reducing conditions
Storage :	This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

HAVCR1 / TIM1 / KIM1 Antibody Related Products & Topics

Proteins:

Molecule	Species	Description //For Detailed Info.------CLICK!	Cat No	Size/Price
KIM-1/TIM1/HAVCR1	Human	KIM-1/TIM-1 Protein , Recombinant	11051-HNCH	100µg($290); Order
KIM-1/TIM1/HAVCR1	Human	KIM-1/TIM-1/Fc Protein , Recombinant	11051-H16H	100µg($290); Order
KIM-1/TIM1/HAVCR1	Human	KIM-1/TIM-1 Protein , Recombinant (aa 1-135)	11051-H08H1	100µg($290); Order
KIM-1/TIM1/HAVCR1	Mouse	KIM-1/TIM-1 Protein , Recombinant	50321-M07H	100µg($290); Order
KIM-1/TIM1/HAVCR1	Mouse	KIM-1/TIM-1/Fc Protein , Recombinant	50321-M16H	100µg($290); Order
KIM-1/TIM1/HAVCR1	Rat	KIM-1/TIM-1 Protein, Recombinant	80003-R07H	100µg($290); Order
KIM-1/TIM1/HAVCR1	Rat	KIM-1/TIM-1 Protein, Recombinant	80003-R16H	100µg($290); Order
KIM-1/TIM1/HAVCR1	Canine	KIM-1/TIM1 Protein, Recombinant	70001-D07H	50µg($290); Order

Antibodies:

Molecule	Application	Description //For Detailed Info.------CLICK!	Cat No	Size/Price
Human KIM-1/TIM1/HACVR1	WB, ELISA	Rabbit Polyclonal Antibody	11051-RP01	Order
Human KIM-1/TIM1/HACVR1	WB, ELISA	Rabbit Polyclonal Antibody (Antigen Affinity Purified)	11051-RP02	100µg($250); Order

HAVCR1 / TIM1 / KIM1 Antibody Background

Human hepatitis A virus (HAV) is a hepatotropic virus that causes acute hepatitis in humans, and its target receptor HAVCR1 is encoded by an important asthma and allergy susceptibility gene in humans. The monkey and human HAVCR1 are the first identified members of the T-cell immunoglobulin mucin (TIM) family, an immunologically important group of receptors that is conserved in vertebrates. Human HAV cellular receptor 1 (HAVCR1), also known as KIM1 and TIM1, is widely expressed with highest levels in kidney and testis. It has been shown that HAVCR1 is expressed on activated CD4+T-cells during the development of helper T-cells responses and associates with immunomodulatory properties. TIM1 is a type 1 integral membrane glycoprotein, and plays a critical role in regulating T-cell differentiation and the development of atopy. It consists of a characteristic six-cysteine Ig-like domain (D1) extended above the cell surface by a mucin-like domain that contains a variable number of threonine, serine, and proline (TSP) hexameric repeats. D1 and its first N-glycosylation site are required for binding of HAV to HAVCR1. It also exists as a soluble form constitutive cleavage by an undefined MMP. In addition to HAV, another identified ligand for HAVCR1 is TIMD4.

References

Silberstein, E. et al., 2001, J Virol. 75 (2): 717-725.
Silberstein, E. et al., 2003, J Virol. 77 (16): 8765-8774.
Tami, C. et al., 2007, J Virol. 81 (7): 3437-3446.
Garner-Spitzer, E. et al., 2009, Vaccine. 27 (2):197-204.

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