Anti-Angiotensinogen Antibody

Cat: 10994-RP02
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Anti-Angiotensinogen Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-Angiotensinogen Antibody
Validated applications
ELISA,IHC-P
Species reactivity
Reacts with: Human
Specificity
Human Angiotensinogen
Immunogen
Recombinant Human SerpinA8 protein (Catalog#10994-H08H)
Preparation
Produced in rabbits immunized with purified, recombinant Human SerpinA8 / angiotensinogen (rh SerpinA8; Catalog#10994-H08H; NP_000020.1; Met 1-Ala 485). SerpinA8 specific IgG was purified by human Serpin A8 affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A & Antigen Affinity
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-Angiotensinogen Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:1000-1:2000  
IHC-P 1:500-1:2000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-Angiotensinogen Antibody (Rabbit Polyclonal antibody) Images
Human Angiotensinogen/SerpinA8 Immunohistochemistry(IHC) 4733
Immunochemical staining of human AGT in human cirrhosis with rabbit polyclonal antibody (1:1000, formalin-fixed paraffin embedded sections).The left panel: tissue incubated with primary antibody;The right panel: tissue incubated with the mixture of primary antibody and antigen (recombinant protein).
Anti-Angiotensinogen Antibody Alternative Names
Anti-ANHU Antibody;Anti-SERPINA8 Antibody
Angiotensinogen Background Information

Angiotensinogen, also known as AGT and SerpinA8, is a member of the serpin family. It is an α-2-globulin that is produced constitutively and released into the circulation mainly by the liver. Angiotensinogen is a essential component of the renin-angiotensin system (RAS) and a potent regulator of blood pressure. Angiotensinogen can be schematically considered to consist of a combination of an angiotensin I (Ang I) function, located at the N-terminal end, and the presence of a serpin (serine protease inhibitor) structure at the opposite end. Angiotensinogen is cleaved into three chains: Angiotensin-1 (Ang I), Angiotensin-2 (Ang II), and Angiotensin-3 (Ang III). Angiotensin-1 is a substrate of ACE (angiotensin converting enzyme) that removes a dipeptide to yield the physiologically active peptide angiotensin-2. Angiotensin-1 and angiotensin-2 can be further processed to generate angiotensin-3, angiotensin-4. Angiotensin 1-7 is cleaved from angiotensin-2 by ACE2. Angiotensin-2 acts directly on vascular smooth muscle as a potent vasoconstrictor, affects cardiac contractility and heart rate through its action on the sympathetic nervous system. Defects in AGT are associated with susceptibility to essential hypertension and renal tubular dysgenesis (RTD). Several serpins (antithrombin, maspin, pigment epithelial-derived factor, and kallistatin) have been recently shown to exert an antiangiogenic activity, suggesting a common mechanism of endothelial cell proliferation and migration. Angiotensinogen/AGT and its renin-cleaved product, des(Ang I)AGT, are also angiogenesis inhibitors, both in vitro and in vivo at concentrations within the range of those observed in plasma. The Angiotensinogen products, that is angiotensin II and possibly angiotensin II-related products, have been found to act locally in modulating adipose tissue growth in an autocrine/paracrine manner. The transient or chronic overexpression of angiotensinogen in adipose tissue favors lipogenesis in adipocytes and leads to a 'vicious' circle whereby adipose tissue development is further increased.

Full Name
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
References
  • Ailhaud G, et al. (2002) Angiotensinogen, adipocyte differentiation and fat mass enlargement. Curr Opin Clin Nutr Metab Care. 5(4): 385-9.
  • Corvol P, et al. (2003) Inhibition of angiogenesis: a new function for angiotensinogen and des(angiotensin I)angiotensinogen. Curr Hypertens Rep. 5(2): 149-54.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-Angiotensinogen Antibody Rabbit Polyclonal ELISA 50337-RP01
    Anti-Angiotensinogen Antibody Rabbit Polyclonal WB,ELISA 50337-RP02
    Anti-Angiotensinogen Antibody Rabbit Monoclonal WB,ELISA,ICC/IF,IF,IP 10994-R001
    Anti-Angiotensinogen Antibody Mouse Monoclonal ELISA(Cap) 10994-MM03
    Anti-Angiotensinogen Antibody Mouse Monoclonal FCM,ICC/IF,IF 10994-MM08
    Anti-Angiotensinogen Antibody (PE) Mouse Monoclonal FCM 10994-MM08-P
    Anti-Angiotensinogen Antibody (PE) Rabbit Monoclonal FCM 10994-R001-P
    Anti-Angiotensinogen Antibody Rabbit Monoclonal IHC-P 10994-R034
    Anti-Angiotensinogen Antibody Rabbit Polyclonal ELISA 10994-RP01
    Anti-Angiotensinogen Antibody (FITC) Rabbit Monoclonal FCM 10994-R001-F
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