Angiopoietin 4 (ANG-4, ANGPT4)

Angiopoietin 4, also known as ANG-4 or ANGPT4, is a protein belonging to the angiopoietin family and is highly expressed in the lung with much lower levels found in other tissues. Angiopoietin 4 / ANG-4 / ANGPT4 is a protein with important roles in vascular development and angiogenesis. All angiopoietins bind with similar affinity to an endothelial cell-specific tyrosine-protein kinase receptor. The mechanism by which they contribute to angiogenesis is thought to involve regulation of endothelial cell interactions with supporting perivascular cells. The protein encoded by this gene functions as an agonist and is an angiopoietin. Angiopoietin 4 secreted ligand for the vascular endothelial restricted receptor tyrosine kinase TEK,including phosphorylation of TEK, promoting angiogenic remodeling as well as vessel maturation and stabilization, predominantly expressed in lung.

Angiopoietin 4 (ANG-4, ANGPT4) Related Areas

Cardiovascular>>Angiogenesis>>Adhesion Molecules in Angiogenesis>> ANGPT4 / ANG-4

Angiopoietin 4 (ANG-4, ANGPT4) Alternative Names

AGP4, ANG-3, ANG4, ANG-4; angiopoietin-3; angiopoietin-4; dJ824F16.2 (angiopoietin 4) [Homo sapiens]

Summaries for Angiopoietin 4 (ANG-4, ANGPT4)

Entrez Gene summary for Angiopoietin 4 (ANG-4, ANGPT4):

Angiopoietins are proteins with important roles in vascular development and angiogenesis. All angiopoietins bind with similar affinity to an endothelial cell-specific tyrosine-protein kinase receptor. The mechanism by which they contribute to angiogenesis is thought to involve regulation of endothelial cell interactions with supporting perivascular cells. The protein encoded by this gene functions as an agonist and is an angiopoietin. [provided by RefSeq, Jul 2008]

Wikipedia summary for Angiopoietin 4 (ANG-4, ANGPT4):

Angiopoietin-4 is a protein that in humans is encoded by the ANGPT4 gene.
Angiopoietins are proteins with important roles in vascular development and angiogenesis. All angiopoietins bind with similar affinity to an endothelial cell-specific tyrosine-protein kinase receptor. The mechanism by which they contribute to angiogenesis is thought to involve regulation of endothelial cell interactions with supporting perivascular cells. The protein encoded by this gene functions as an agonist and is an angiopoietin.

Human Angiopoietin 4 (ANG-4, ANGPT4) Protein General Information

 

• Protein names: Angiopoietin 4
  Short name=ANG-4
• Sequence length: 503 AA.
• Domain: Coiled coil
  Signal
• Sequence similarities: Contains 1 fibrinogen C-terminal domain.
• Subunit structure: Homodimer; disulfide-linked. Interacts with TEK/TIE2.
• Subcellular location: Secreted.
• Tissue specificity: Highly expressed in the lung with much lower levels found in other tissues.

General information above from UniProt

Function for Angiopoietin 4 (ANG-4, ANGPT4) Protein

UniProtKB:

Angiopoietin 4 binds to TEK/TIE2, modulating ANGPT1 signaling. Angiopoietin 4 can induce tyrosine phosphorylation of TEK/TIE2. Angiopoietin 4 promotes endothelial cell survival, migration and angiogenesis.

Genatlas:

• Angiopoietin 4 is secreted ligand for the vascular endothelial restricted receptor tyrosine kinase TEK, including phosphorylation of TEK
• Angiopoietin 4 promotes angiogenic remodeling as well as vessel maturation and stabilization
• Angiopoietin 4 activates tyrosine-protein kinase receptor tie 2

Homology for human Angiopoietin 4 (ANG-4, ANGPT4)

• homolog to murine Angpt4
• homolog to rattus Agpt4
• homolog to ANGTP1
• homolog to ANGPT2