Angiopoietin-2 / ANG 2 Protein & Antibody

Angiopoietin-2 / ANG 2 Products

Angiopoietin-2 / ANG 2 Protein, Recombinant

Molecule	Species	Description	Cat. No
Angiopoietin-2/ANG 2	Human	Angiopoietin-2/ANG 2/Fc Protein, Recombinant	10691-H02H
Angiopoietin-2/ANG 2	Human	Angiopoietin-2/ANG 2 Protein, Recombinant	10691-H08H

  10691-H02H: Immobilized recombinant human Angiopoietin-2 at 10 µg/ml (100 µl/well) can bind Human Tie2/Fc chimera with a range of 0.2-20 µg/ml Measured by its binding ability in a functional ELISA.

  10691-H08H:

1. Measured by its ability to bind recombinant human Tie2-His in a functional ELISA.

2. Measured by its ability to bind recombinant human Tie2-Fch in a functional ELISA.

Angiopoietin-2 / ANG 2 Antibody

Molecule	Application	Description	Cat. No
Human Angiopoietin-2/ANG 2	WB, ELISA	Angiopoietin-2 / ANG 2 Antibody	10691-RP01
Human Angiopoietin-2/ANG 2	WB, ELISA	Angiopoietin-2 / ANG 2 Antibody (Antigen Affinity Purified)	10691-RP02

Angiopoietin-2 / ANG 2 cDNA Clone

Molecule	Species	Description	Cat. No
Angiopoietin-2/ANG 2	Human	Homo sapiens Angiopoietin-2/ANG 2/ANGPT2 cDNA Clone	HG10691-M
Angiopoietin-2/ANG 2	Mouse	Mus musculus Angiopoietin-2/ANG 2/ANGPT2 cDNA Clone	MG50298-M

Angiopoietin-2 / ANG 2 Alternative

Angiopoietin 2, ANG2, ANGPT2, AGPT2 [Homo sapiens]

Angiopoietin 2, Ang2, Agpt2, Ang-2, Angrp, Rnase5b [Mus musculus]

Angiopoietin-2 / ANG 2 Related Areas

Cancer>>Growth Factor & Receptor>>Angiopoietin/Tie>>Angiopoietin-2/ANG 2

Angiopoietin-2 Background

Angiopoietin-2 (ANG 2, or ANGPT2), is a member of the ANG family, which plays an important role in angiogenesis during the development and growth of human cancers. Both ANGPT-1 and ANGPT-2 appear to bind to the tyrosine kinase receptor, Tie-2, found primarily on the luminal surface of endothelial cells. ANG-2's role in angiogenesis generally is considered as an antagonist for ANG1, inhibiting ANG1-promoted Tie2 signaling, which is critical for blood vessel maturation and stabilization. ANG-2 modulates angiogenesis in a cooperative manner with another important angiogenic factor, vascular endothelial growth factor A. Genetic studies have revealed that ANG-2 also is critical in lymphangiogenesis during development. ANG-2 has multiple physiologic effects that regulate vascular tone, hormone secretion, tissue growth and neural activity. Several reports indicate that ANG-2 can induce neovascularization in experimental systems due to the expression of different growth factors such as angiopoietin 2, vascular endothelial factor, and its receptor, fibroblast growth factor, platelet derived growth factor, transforming growth factor beta and epidermal growth factor. In addition, ANG-2 is strongly expressed in the vasculature of many tumors and it has been suggested that ANG-2 may act synergistically with other cytokines such as vascular endothelial growth factor to promote tumor-associated Angiogenesis and tumor progression.

Angiopoietin-2 Related Studies

1. Thomas M, et al. (2009) The role of the Angiopoietins in vascular morphogenesis. Angiogenesis. 12(2): 125-37.
2. Hu B, et al. (2009) Angiopoietin-2: development of inhibitors for cancer therapy. Curr Oncol Rep. 11(2): 111-6.
3. Fiedler U, et al. (2006) Angiopoietins: a link between angiogenesis and inflammation. Trends Immunol. 27: 552–8.
4. Escobar E, et al. (2004) Angiotensin II, cell proliferation and angiogenesis regulator: biologic and therapeutic implications in cancer. Curr Vasc Pharmacol. 2(4): 385-99.