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Angiogenesis

Sino Biological offers a comprehensive set of reagents for studying a variety of areas in angiogenesis process, involving angiogenesis growth factors, angiogenesis inhibitors, proteases and adhesion molecules in angiogenesis. These high quality reagents include active proteins, highly specific antibodies (mouse Mabs, rabbit Mabs, rabbit Pabs), and cDNA clones.

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    Angiogenesis Background

    Angiogenesis is the process of new blood vessel formation, which is an essential process during development, as well as wound healing. Angiogenesis is regulated by a very sensitive interplay of growth factors and inhibitors. Chemical stimulation of angiogenesis is performed by several growth factors, including FGFs (fibroblast growth factors), VEGFs (vascular endothelial growth factors), PDGFs, eprins, angiopoietins, TGF-beta and other. Angiogenesis inhibitors can be endogenous or exogenous (such as drug or a dietary component). Endogenous angiogenesis inhibitors may be interleukins, interferons, chemokines, or growth factor regulators.

    Imbalance of angiogenesis stimulation and inhibition can lead to disease. In cancer, rheumatoid arthritis, and diabetic eye disease, excessive angiogenesis feeds diseased tissue and destroys normal tissue. Conversely, insufficient angiogenesis underlies conditions such as coronary heart disease, stroke and delayed wound healing, where inadequate blood-vessel growth leads to poor circulation and tissue death. The modern clinical application of the principle of angiogenesis can be divided into two main areas: anti-angiogenic therapies, which are being employed to fight cancer and malignancies, and pro-angiogenic therapies, which are being explored as options to treat cardiovascular diseases.

    Angiogenesis References

      1. Carmeliet P. (2005) Angiogenesis in life, disease and medicine. Nature. 438(7070):932-6.
      2. Ferrara N, et al. (2005) Angiogenesis as a therapeutic target. Nature. 438(7070):967-74.
      3. Ribatti D, et al. (2009) Angiogenesis in asthma. Clin Exp Allergy. 39(12):1815-21.
      4. Tan A, et al. (2010) Angiogenesis-inhibitors for metastatic thyroid cancer. Cochrane Database Syst Rev. 3:CD007958.
      5. Le Bourhis X, et al. (2010) Role of endothelial progenitor cells in breast cancer angiogenesis: from fundamental research to clinical ramifications. Breast Cancer Res Treat. 120(1):17-24.