Amyotrophic Lateral Sclerosis Therapeutic Targets

Protein Name	Alternative Names	BioChemical Class / Role	Products (Cat NO)
			Protein	Antibody	Gene cDNA clones
PSMA	FOLH1, FGCP, FOLH, GCP2, GCPII, NAALAD1, NAALAdase, PSM, mGCP	PSMA/FOLH1 is a single-pass type II membrane protein which belongs to the peptidase M28 family and M28B subfamily. It has both folate hydrolase and N-acetylated alpha linked acidic dipeptidase (NAALADase) activity.It also shows a promising role in directed imaging and therapy of recurrent or metastatic disease.	50214-M07H		MG50214-M
TNF-alpha	TNF, TNFA, TNFSF2, DADB-70P7.1, DIF	TNF-alpha (Tumor necrosis factor alpha ), also known as TNF, TNFA or TNFSF2, is the prototypic cytokine of the TNF superfamily, and is a multifunctional molecule involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. TNF-alpha is involved in fighting against the tumorigenesis, thus, is regarded as a molecular insight in cancer treatment.	10602-HNAE, 50349-MNAE	10602-MM01, 10602-R211, 10602-RP03	HG10602-M, MG50349-M
Bcl-xL	Bcl-X, BCL2L1, BCL-XL/S, BCL2L, BCLX, BCLXL, BCLXS, DKFZp781P2092, bcl-xS				HG10455-M, MG50012-M
Bcl-2/BCL2	TP53, p53, LFS1, TRP53, FLJ92943				HG10195-M
P53	TP53, p53, LFS1, TRP53, FLJ92943				HG10182-M
p38 delta/MAPK13	MGC99536, PRKM13, SAPK4, p38delta	p38 delta/MAPK13 responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating downstream targets. Plays a role in the regulation of protein translation by phosphorylating and inactivating EEF2K.			HG10747-M
p38 alpha/MAPK14	p38, CSBP1, CSBP2, Mxi2, PRKM14, PRKM15, RK, CSPB1, SAPK2A, EXIP, RP1-179N16.5	Four alternatively spliced transcript variants of p38 have been reported, p38 alpha (also known as MAPK14) is the best characterized isoform. p38 alpha/MAPK14 is activated following exposure to products of microbial pathogens, physical-chemical stimuli and cytokines. Furthermore, the p38 alpha/MAPK14 has been suggested to play a critical role linking developmental and stress-induced erythropoiesis through regulation of Epo expression.	10081-H08B, 10081-H07B, 10646-HNCB		HG10081-M, HG10646-M
PKC alpha	PRKCA, AAG6, MGC129900, MGC129901, PKC-alpha, PKCA, PRKACA				HG10026-M
PKC beta	PRKCB, MGC41878, PKC-beta, PKCB, PRKCB1, PRKCB2				HG10750-M
PKC epsilon	PRKCE, MGC125656, MGC125657, PKCE, nPKC-epsilon				HG10857-M
PKC gamma	PRKCG, MGC57564, PKC-gamma, PKCC, PKCG, SCA14				HG11242-M
PKC iota	PRKCI, DXS1179E, MGC26534, PKCI, nPKC-iota				HG10534-M
PKC zata	PRKCZ, PKC-ZETA, PKC2				HG10541-M
Caspase-1	CASP1, ICE, IL1BC, P45, CASP-1				HG11148-M
Caspase-3	CASP3, CPP32, SCA-1, CPP32B				HG10050-M
Caspase-9	CASP9, RP11-265F14.3, APAF-3, APAF3, CASPASE-9c, ICE-LAP6, MCH6				HG11151-M
CPX3	GPx-P, GSHPx-3, GSHPx-P				HG10940-M, MG50244-M
TNFR2	CD120b, TNFRSF1B	A member to the TNF-receptor superfamily. TNFR2 inhibits TNF-alpha action by competing with cell surface receptors in binding TNF-alpha, thereby blocking its biologic effects. Knockout studies in mice suggest a role of TNFR2 in protecting neurons from apoptosis by stimulating antioxidative pathways.	10872-H03H, 10872-H08H	10417-RP01, 10417-RP02	HG10417-M, MG50128-M