Aminoacylase-1 / ACY1 Protein & Antibody

Aminoacylase-1 / ACY1 Products

Aminoacylase-1 / ACY1 Protein, Recombinant

Molecule	Species	Description	Cat. No
Aminoacylase-1/ACY1	Human	Aminoacylase-1/ACY1 Protein, Recombinant	10549-H08B
Aminoacylase-1/ACY1	Mouse	Aminoacylase-1/ACY1 Protein, Recombinant	50008-M08H

  10549-H08B:  The specific activity is > 4,000 pmoles / min / µg. Measured by its ability to cleave N-acetyl-L-Methione (Ac-Met).

  50008-M08H:  The specific activity is > 4,000 pmoles / min / µg. Measured by its ability to cleave N-acetyl-L-Methione (Ac-Met).

Aminoacylase-1 / ACY1 Antibody

Molecule	Application	Description	Cat. No
Human Aminoacylase-1/ACY1	WB, ELISA	Aminoacylase-1/ACY1 Antibody, Mouse MAb	10549-MM01
Human Aminoacylase-1/ACY1	WB, ELISA	Aminoacylase-1/ACY1 Antibody, Rabbit PAb	10549-RP01
Human Aminoacylase-1/ACY1	WB, ELISA	Aminoacylase-1/ACY1 Antibody, Rabbit PAb (Antigen Affinity Purified)	10549-RP02

Aminoacylase-1 / ACY1 cDNA Clone

Molecule	Species	Description	Cat. No
Aminoacylase-1/ACY1	Human	Homo sapiens Aminoacylase-1/ACY1 cDNA Clone(NM_000666.1)	HG10549-M
Aminoacylase-1/ACY1	Mouse	Homo sapiens Aminoacylase-1/ACY1 cDNA Clone(NM_000666.1)	MG50008-M

Aminoacylase-1 / ACY1 Related Areas

Enzyme>>Protease & Regulator>>Metalloprotease & Regulator>>Aminoacylase-1/ACY1

Aminoacylase-1 / ACY1 Alternative Names

ACYLASE, ACY1, ACY-1, aminoacylase-1, ACY1D [Homo sapiens]

Acy1, Acy-1, 1110014J22Rik [Mus musculus]

Aminoacylase-1 / ACY1 Background

Aminoacylase 1 (ACY1), a metalloenzyme that removes amide-linked ACY1 groups from amino acids and may play a role in regulating responses to oxidative stress. Both the C-terminal fragment found in the two-hybrid screen and full-length ACY1 co-immunoprecipitate with SphK1. Though both C-terminal and full-length proteins slightly reduce SphK1 activity measured in vitro, the C-terminal fragment inhibits while full-length ACY1 potentiates the effects of SphK1 on proliferation and apoptosis. It suggested that ACY1 physically interacts with SphK1 and may influence its physiological functions. As a homodimeric zinc-binding enzyme, Aminoacylase 1 catalyzes the hydrolysis of N alpha-acylated amino acids. Deficiency of Aminoacylase 1 due to mutations in the Aminoacylase 1 (ACY1) gene follows an autosomal-recessive trait of inheritance and is characterized by accumulation of N-acetyl amino acids in the urine.

Aminoacylase-1 / ACY1 Related Studies

1. Sommer A, et al. (2011) The molecular basis of aminoacylase 1 deficiency. Biochim Biophys Acta. 1812(6): 685-90.
2. Maceyka M, et al. (2004) Aminoacylase 1 is a sphingosine kinase 1-interacting protein. FEBS Lett. 568(1-3): 30-4.
3. Cook RM, et al.(1993) Human aminoacylase-1. Cloning, sequence, and expression analysis of a chromosome 3p21 gene inactivated in small cell lung cancer. J Biol Chem. 268(23): 17010-7.