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ACY1 / Aminoacylase-1 Antibody, Mouse MAb

  • ACY1 / Aminoacylase-1 Antibody, Mouse MAb, Western blot
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Human ACY1 Antibody Product Information
Immunogen:Recombinant Human ACY1 protein (Catalog#10549-H08B)
Clone ID:7A11C6C2
Ig Type:Mouse IgG1
Concentration:
Endotoxin:
Formulation:0.2 μm filtered solution in PBS with 5% trehalose
Preparation:This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human ACY1 (rh ACY1; Catalog#10549-H08B; NP_000657.1; Met 1-Ser 408). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
Human ACY1 Antibody WB Application Image
Other ACY1 Antibody Products
Reactivity: Human  
Application: IHC-P  
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10549-MM02-50
10549-MM02-200
10549-MM02-100
50 µg 
200 µg 
100 µg 
Add to Cart
Reactivity: Human  
Application: FCM  
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10549-R006-F-25
10549-R006-F-100
25 Test 
100 Tests 
Add to Cart
Reactivity: Human  
Application: IHC-P  
  • Slide 1
10549-R128-50
10549-R128-100
50 µg 
100 µg 
Add to Cart
Reactivity: Human  
Application: ELISA  WB  IP  
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10549-RP02-50
10549-RP02-200
10549-RP02-100
50 µg 
200 µg 
100 µg 
Add to Cart
Reactivity: Human  
Application: ELISA  
    10549-RP01-400
    10549-RP01-200
    10549-RP01-100
    400 µg 
    200 µg 
    100 µg 
    Add to Cart
    Reactivity: Human  
    Application: FCM  IF  ICC/IF  
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    10549-R006-50
    10549-R006-100
    50 µg 
    100 µg 
    Add to Cart
    Reactivity: Mouse  
    Application: 
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    • Slide 1
    • Slide 1
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    50008-T60-50
    50008-T60-200
    50008-T60-100
    50 µg 
    200 µg 
    100 µg 
    Add to Cart
    Reactivity: Mouse  
    Application: ELISA  
      50008-RP01-400
      50008-RP01-200
      50008-RP01-100
      400 µg 
      200 µg 
      100 µg 
      Add to Cart
      Aminoacylase-1/ACY1 Background

      Aminoacylase 1 (ACY1), a metalloenzyme that removes amide-linked ACY1 groups from amino acids and may play a role in regulating responses to oxidative stress. Both the C-terminal fragment found in the two-hybrid screen and full-length ACY1 co-immunoprecipitate with SphK1. Though both C-terminal and full-length proteins slightly reduce SphK1 activity measured in vitro, the C-terminal fragment inhibits while full-length ACY1 potentiates the effects of SphK1 on proliferation and apoptosis. It suggested that ACY1 physically interacts with SphK1 and may influence its physiological functions. As a homodimeric zinc-binding enzyme, Aminoacylase 1 catalyzes the hydrolysis of N alpha-acylated amino acids. Deficiency of Aminoacylase 1 due to mutations in the Aminoacylase 1 (ACY1) gene follows an autosomal-recessive trait of inheritance and is characterized by accumulation of N-acetyl amino acids in the urine.

      Human Aminoacylase-1/ACY1 References
    • Sommer A, et al. (2011) The molecular basis of aminoacylase 1 deficiency. Biochim Biophys Acta. 1812(6): 685-90.
    • Maceyka M, et al. (2004) Aminoacylase 1 is a sphingosine kinase 1-interacting protein. FEBS Lett. 568(1-3): 30-4.
    • Cook RM, et al.(1993) Human aminoacylase-1. Cloning, sequence, and expression analysis of a chromosome 3p21 gene inactivated in small cell lung cancer. J Biol Chem. 268(23): 17010-7.
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      All information of our products is subject to change without notice. Please refer to COA enclosed in shipped package for the newest information.
      Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"