Alzheimer's Disease Therapeutic Targets

Protein Name	Alternative Names	BioChemical Class / Role	Products (Cat NO)
			Protein	Antibody	Gene cDNA clones
GSK3B	GSK3beta isoform	GSK3B was originally identified as an enzyme that regulates glycogen synthesis and glucose storage in response to insulin, and more recently was rediscovered as a key regulatory component involved in energy metabolism, neuronal cell development, and body pattern formation, as well as tumorigenesis. Studies in mice show that overexpression of GSK3B gene may be relevant to the pathogenesis of Alzheimer disease.	10044-H07B		HG10044-M
HTR4					HG10753-M
BACE1	ASP2, BACE, FLJ90568, HSPC104, KIAA1149	As a member of the peptidase A1 protein family, BACE1 is a type I single-pass membrane glycoprotein and aspartic protease that is found mainly in the Golgi.  which is the major constituent of amyloid plaques in the brains of individuals afflicted with Alzheimers disease (AD), and accordingly, BACE1 is implicated in the onset and progression of AD.	10064-H02H 10064-H08H 10064-HCCH 50002-M08H	10064-MM01 10064-MM02 10064-RP03	HG10064-M MG50002-M
Beta-Amyloid/Abeta	ABETA, APPI, protease nexin II, PN2, AAA, ABPP, AD1, CTFgamma, CVAP	Amyloid precursor protein (APP) is a type I transmembrane protein expressed in many tissues and concentrated in the synapses of neurons. APP can be processed by two different proteolytic pathways. In one pathway, APP is cleaved by β- and γ-secretase to produce the Beta-Amyloid protein which is the principal component of the amyloid plaques, the major pathological hallmark of Alzheimer’s disease (AD), while in the other pathway	10703-H02H		HG10703-M
IL-1 alpha	IL1F1, IL1A, IL-1A, IL1, IL1-ALPHA	Interleukin 1 (IL-1) is an important cytokine mediator involved in a variety of biological processes including immune responses, inflammatory, and promoting tissue degradation. IL-1 comprises two proteins, designated as IL-1 alpha and IL-1 beta which are encoded by distinct genes, and bind the same surface receptors with high affinity. Elevated levels of IL-1 alpha have been associated with a number of chronic disorders, including rheumatoid arthritis and Alzheimer’s disease, and therefore, may provide novel targets for therapeutic approaches aimed at controlling inflammatory processes.	10128-HNCH		HG10128-M MG50114-M
IL-1 beta	IL1F2, IL1B, IL-1, IL1-BETA	Interleukin 1 (IL-1) is a family of polypeptide cytokines consisting of two agonists, IL-1 alpha (IL-1F1) and IL-1 beta (IL-1F2) encoded by two distinct genes and perform identical biological functions. IL-1 beta is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1  (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis.	10139-HNAE		HG10139-M MG50101-M
p38 alpha/MAPK14	p38, CSBP1, CSBP2, Mxi2, PRKM14, PRKM15, RK, CSPB1, SAPK2A, EXIP, RP1-179N16.5	Four alternatively spliced transcript variants of p38 have been reported, p38 alpha (also known as MAPK14) is the best characterized isoform. p38 alpha/MAPK14 is activated following exposure to products of microbial pathogens, physical-chemical stimuli and cytokines. Furthermore, the p38 alpha/MAPK14 has been suggested to play a critical role linking developmental and stress-induced erythropoiesis through regulation of Epo expression.	10081-H08B 10081-H07B 10646-HNCB		HG10081-M HG10646-M
ECE1	ECE, ECE-1				HG10887-M