Alpha amylase (AMY2A)

Alpha-amylase is the major form of amylase found in humans and other mammals. Amylases are secreted proteins that hydrolyze 1,4-alpha-glucoside bonds in oligosaccharides and polysaccharides, and thus catalyze the first step in digestion of dietary starch and glycogen. Alpha-amylase hydrolyses alpha bonds of large, alpha-linked polysaccharides, such as starch and glycogen, yielding glucose and maltose. Amylases is widely expressed and is most prominent in pancreatic juice and saliva, each of which has its own isoform of human α-amylase. They behave differently on isoelectric focusing, and can also be separated in testing by using specific monoclonal antibodies.

Alpha amylase (AMY2A) Alternative Names

AMY2, AMY2B, PA, 1,4-alpha-D-glucan glucanohydrolase, Alpha-amylase, amylase, pancreatic, alpha-2A, found in the pancreas, glycogenase, pancreatic Alpha-amylase, pancreatic amylase 2A, pancreatic amylase alpha 2A [Homo sapiens]

Summaries for Alpha amylase (AMY2A)

Entrez Gene summary for Alpha amylase (AMY2A):

Amylases are secreted proteins that hydrolyze 1,4-alpha-glucoside bonds in oligosaccharides and polysaccharides, and thus catalyze the first step in digestion of dietary starch and glycogen. The human genome has a cluster of several amylase genes that are expressed at high levels in either salivary gland or pancreas. AMY2A gene encodes an amylase isoenzyme produced by the pancreas. [provided by RefSeq, Jul 2008]

Wikipedia summary for Alpha amylase (AMY2A):

Pancreatic alpha-amylase is an enzyme that in humans is encoded by the AMY2A gene.
Amylases are secreted proteins that hydrolyze 1,4-alpha-glucoside bonds in oligosaccharides and polysaccharides, and thus catalyze the first step in digestion of dietary starch and glycogen. The human genome has a cluster of several amylase genes that are expressed at high levels in either salivary gland or pancreas. This gene encodes an amylase isoenzyme produced by the pancreas.

Human Alpha amylase (AMY2A) Protein General Information

 

• Protein names: Pancreatic alpha-amylase
  Short name=PA
• Sequence length: 511 AA.
• Domain: Signal
• Sequence similarities: Belongs to the glycosyl hydrolase 13 family.
• Cofactor: Binds 1 calcium ion per subunit.
  Binds 1 chloride ion per subunit.
• Subunit structure: Monomer.
• Subcellular location: Secreted › extracellular space.
• Catalytic activity: Endohydrolysis of (1->4)-alpha-D-glucosidic linkages in polysaccharides containing three or more (1->4)-alpha-linked D-glucose units.

General information above from UniProt

Function for Alpha amylase (AMY2A) Protein

Genatlas:

• AMY2A has a hydrolase activity acting on glycosyl bonds

Homology for human Alpha amylase (AMY2A)

• ortholog to murine Amy2
• homolog to Drosophila Amy-p
• homolog to C.elegans C50B6.7