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Alpha-2-glycoprotein (AZGP1)

Alpha-2-glycoprotein, also known as AZGP1, belongs to the MHC class I family. It can be detected in body fluids such as serum, sweat, and seminal and breast cyst fluids. It has been shown that alpha-2-glycoprotein can stimulate lipolysis by adipocytes in vivo and in vitro. Thus it is believed that alpha-2-glycoprotein plays an important role in the regulation of body weight, and age-dependent changes in genetically influenced obesity, and it also regulates melanin production by normal and malignant melanocytes. Alpha-2-glycoprotein is produced by both white and brown fat adipocytes and may act in a local autocrine fashion in the reduction of adiposity in cachexia.

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Alpha-2-glycoprotein (AZGP1) Related Products

Alpha-2-glycoprotein (AZGP1) Proteins

Alpha-2-glycoprotein (AZGP1) Antibodies

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Alpha-2-glycoprotein (AZGP1) ELISA Pair sets

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Alpha-2-glycoprotein (AZGP1) cDNA Clones

Alpha-2-glycoprotein (AZGP1) Related Areas

Alpha-2-glycoprotein (AZGP1) Related Pathways

Alpha-2-glycoprotein (AZGP1) Alternative Names

ZA2G, ZAG, Alpha-2-glycoprotein, zinc, Zn-alpha2-glycoprotein, zinc-alpha-2-glycoprotein, zn-alpha-2-GP, zn-alpha-2-glycoprotein [Homo sapiens]

Zag, major histocompatibility complex class I-like protein, zinc-alpha-2-glycoprotein, zn-alpha-2-GP [Mus musculus]

Summaries for Alpha-2-glycoprotein (AZGP1)

Wikipedia summary for Alpha-2-glycoprotein (AZGP1):

Zinc-alpha-2-glycoprotein is a protein that in humans is encoded by the AZGP1 gene.
AZGP1 gene expresses a soluble protein that stimulates lipolysis, induces a reduction in body fat in mice, is associated with the cachexia related to cancer, and is known to be expressed in secretory cells of lung epithelium. In 2009, it was found that smoking increases expression of this gene, which is why smoking cessation leads to weight gain.

Human Alpha-2-glycoprotein (AZGP1) Protein General Information

 

Protein names

Alpha-2-glycoprotein

Sequence length

298 AA.

Domain

Signal

Sequence similarities:

Belongs to the MHC class I family.
Contains 1 Ig-like C1-type (immunoglobulin-like) domain.

Post-translational modification:

N-glycosylated. N-glycan at Asn-128: Hex5HexNAc4.

Subunit structure

Interacts with PIP.

Subcellular location: Secreted.
Tissue specificity

Blood plasma, seminal plasma, urine, saliva, sweat, epithelial cells of various human glands, liver.

Caution: It is uncertain whether Met-1 or Met-4 is the initiator.
Sequence caution: The sequence AAA61311.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.
The sequence BAA03123.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence BAA14417.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence CAA42438.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

General information above from UniProt

Function for Alpha-2-glycoprotein (AZGP1) Protein

UniProtKB:

AZGP1 stimulates lipid degradation in adipocytes and causes the extensive fat losses associated with some advanced cancers. AZGP1 may bind polyunsaturated fatty acids.

Genatlas:

  • AZGP1 stimulates lipid degradation in adipocytes
  • AZGP1 causes the extensive fat losses associated with some advanced cancers
  • AZGP1 plays an important role in the mobilization and utilization of stored lipids, and may play an important role in the regulation of adipose mass in obesity and cachexia
  • AZGP1 is lipid-mobilizing factor involved in regulating lipid metabolism and adiposity
  • AZGP1 is tumor suppressor in pancreatic cancer inducing mesenchymal-to-epithelial transdifferentiation by inhibiting TGF-beta-mediated ERK signaling

Homology for human Alpha-2-glycoprotein (AZGP1)

  • ortholog to murine Azgp1
  • homolog to C.elegans F52C6.9

Phenotype Information for Alpha-2-glycoprotein (AZGP1)

Drugs for Alpha-2-glycoprotein (AZGP1)

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