Allergy Therapeutic Targets

Protein Name	Alternative Names	BioChemical Class / Role	Products (Cat NO)
			Protein	Antibody	Gene cDNA clones
Integrin alpha 4/CD49d	ITGA4.IA4, MGC90518	CD49d is an integrin alpha subunit. It makes up half of the α4β1 lymphocyte homing receptor. Integrins alpha-4/beta-1 (VLA-4) and alpha-4/beta-7 are receptors for fibronectin. On activated endothelial cells integrin VLA-4 triggers homotypic aggregation for most VLA-4-positive leukocyte cell lines. It may also participate in cytolytic T-cell interactions with target cells.			MG50049-M
IL-13	ALRH, BHR1, IL13, MGC116786, MGC116788, MGC116789, P600	IL-13, a single-chain glycosylated polypeptide, is critical in regulating inflammatory and immune responses. IL-13 is associated primarily with the pathophysiology of atopic respiratory diseases such as allergic asthma. In addition, studies have identified IL13 expression as a common feature of cHL (classical Hodgkin lymphoma).	10369-H01H 11057-CNAH	10369-MM01 10369-MM02	HG10369-M MG50225-M, 11057-M
IL-1R2/CD121b	IL1R2, IL-1RII, IL1RB, MGC47725	IL-1R2/CD121b can bind all three forms of IL1 (IL1 alpha, IL1 beta and IL1ra) but does not transmit IL1 signals. In addition to the membrane-bound form, IL1RII also exists as the soluble form, and either acts as a decoy receptor that inhibits IL1 action by blocking the binding of IL1 to the type I receptor complex. It is a potent antagonist of IL1 action, and serves as a potential therapeutic target.	10111-H02H		HG10111-M
ADAM8/CD156	MS2, MGC134985				HG10205-M
TLR1/CD281	TIL,  CD281,  rsc786,  KIAA0012,  MGC104956,  MGC126311,  MGC126312				HG10151-M MG50230-M
TLR2/CD282	TIL4				HG10061-M
TLR3/CD283					HG10190-M MG50161-M
TLR4/CD284	TOLL, hToll, ARMD10				HG10146-M
TLR5/TIL3	SLEB1, FLJ10052				HG10067-M
CD64	FCGR1	An Fc receptor that binds monomeric IgG-type antibodies with high affinity, which is normally found on macrophages and monocytes. After binding IgG, CD64 interacts with an accessory chain known as the common γ chain, which possesses an ITAM motif that is necessary for triggering cellular activation.	10256-H08H, 50086-M08H		HG10256-M MG50086-M
CD32	CD32A, CD32B, FcγRII, FCGR2, FCGR2A, FCGR2B, FCG2, CDw32, IGFR2, FcGR	Fcγ RII and RIII are low affinity receptors that recognize IgG as aggregates surrounding multivalent antigens during late immune responses. Three closely related genes encodes human CD32 class by and designated Fcγ RII A, B, and C which share 94 - 99% amino acid identity in their extracellular domains.	50030-M08H 10374-H08H 10259-H08H	50030-RP01 50030-RP02 10374-MM01 10374-MM02 10259-MM02 10259-RP01 10259-RP03	MG50030-M HG10374-M HG10260-M HG10259-M
CD16a	RP11-5K23.1, CD16, CD16A, FCG3, FCGR3, FCGRIII, FCR-10, FCRIII, FCRIIIA, IGFR3	In human, CD16 is expressed as two distinct forms (CD16a and CD16b) encoded by two different highly homologous genes in a cell type-specific manner. CD16a has an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain and delivers an activation signal in the immune responses. As an inflammatory mediator, CD16a receptor is involved in phagocytosis, secretion of enzymes, antibody-dependent cellular cytotoxicity (ADCC), mast cell degranulation, and clearance of immune complexes. Aberrant expression or mutations in this gene are implicated in susceptibility to recurrent viral infections, systemic lupus erythematosus, and alloimmune neonatal neutropenia.	10389-H08H	10389-MM01 10389-MM02 10389-MM03	HG10389-M
CD16b	CD16, FCG3, FCGR3,FCGR3B	CD16b is unique in that it is the only Fc receptor linked to the plasma membrane. The GPI-anchored proteins often preferentially localize to DRMs (detergent-resistant membranes) that are rich in sphingolipids and cholesterol and play an important role in signal transduction. CD16b associates with complement receptor 3 (CR3, Mac-1, CD11b/CD18) which can indirectly link CD16b to the actin cytoskeleton.	11046-H08H	11046-RP01	HG11046-M
CD16-2	4833442P21Rik, FcgRIV, FcgammaRIV, Fcgr3a, Fcrl3, Fcgr4	Mouse FCGR4, also referred to as CD16-2, has been proposed to be the mouse homolog of human Fc γ RIIIA because of high sequence homology (60 % aa identity). Although mouse FCGR4 functioned as a low-affinity IgE receptor for all IgE allotypes, ligation of FCGR4 by antigen-IgE(b) immune complexes promotes macrophage-mediated phagocytosis, presentation of antigen to T cells, production of proinflammatory cytokines and the late phase of cutaneous allergic reactions.	50036-M08H	50036-RP01 50036-RP01	MG50036-M