Alkaline Phosphatase Protein (ALPL, TNAP Protein)

 Tissue-Nonspecific Alkaline Phosphatase

Alkaline Phosphatase Products

Alkaline Phosphatase Protein, Recombinant

Molecule	Species	Description	Cat. No
ALPL/TNAP	Human	ALPL/TNAP Protein, Recombinant	10440-H08H

Alkaline Phosphatase cDNA Clone

Molecule	Species	Description	Cat. No
ALPL/TNAP	Human	Homo sapiens ALPL/TNAP cDNA Clone(NM_000478.3)	HG10440-M

Alkaline Phosphatase Related Areas

Enzyme>>Phosphatase & Regulator>>ALPL/TNAP

Signal Transduction>>Phosphatase & Regulator>>ALPL/TNAP

Stem Cell>>Mesenchymal Stem Cell (MSC)>>Osteoblast & Osteoclast Marker>>ALPL/TNAP

Stem Cell>>Embryonic Stem Cell (ESC)>>Embryonic Stem Cell Marker>>ALPL/TNAP

Alkaline Phosphatase Alternative Names

Alkaline Phosphatase, ALPL, TNAP, AP-TNAP, FLJ40094, FLJ93059, HOPS, MGC161443, MGC167935, TNSALP [Homo sapiens]

Alkaline Phosphatase, Alpl, TNAP, AP-TNAP, RP23-277N22.4, Akp-2, Akp2, TNSALP [Mus musculus]

Alkaline Phosphatase Background

Alkaline phosphatase (ALPL) is a hydrolase enzyme responsible for removing phosphate groups from many types of molecules, including nucleotides, proteins, and alkaloids. The process of removing the phosphate group is called dephosphorylation. As the name suggests, alkaline phosphatases are most effective in an alkaline environment. It is sometimes used synonymously as basic phosphatase. Alkaline phosphatases (APs) are ubiquitous in many species, from bacteria to human. Four genes encode AP isoenzymes in humans and rodents. Three AP genes are expressed in a tissue-specific manner (i.e., placental, embryonic, and intestinal AP isoenzymes). Expression of the fourth AP gene is nonspecific to a single tissue and is especially abundant in bone, liver, and kidney. This isoenzyme is also called tissue-nonspecific alkaline phosphatase (TNAP). The enzyme tissue non-specific alkaline phosphatase (TNAP) belongs to the ectophosphatase family. TNAP is present in large amounts in bone in which it plays a role in mineralization.

Alkaline Phosphatase Related Studies

1. Brun-Heath I, et al. (2011) Differential expression of the bone and the liver tissue non-specific alkaline phosphatase isoforms in brain tissues. Cell Tissue Res. 343(3): 521-36.
2. Whyte MP, et al. (1995) Alkaline phosphatase: placental and tissue-non-specific isoenzymes hydrolyze phosphoethanolamine, inorganic pyrophosphate, and pyridoxal 5′-phosphate. J Clin Invest. 95: 1440–5.
3. Whyte MP. (1994) Hypophosphatasia and the role of alkaline phosphatase in skeletal mineralization. Endocrinol Rev. 4: 439–61.
4. Weinreb M, et al. (1990) Different pattern of alkaline phosphatase, osteopontin and osteocalcin expression in developing rat bone visualized by in situ hybridization. J Bone Miner Res. 5: 831–42.