Alkaline Phosphatase, Intestinal (ALPI, IAP)

Alkaline phosphatase, intestinal also known as ALPI is digestive brush-border enzyme which is upregulated during small intestinal epithelial cell differentiation. ALPI is also referred to as IAP and it is released into the lumen after a high-fat diet. ALPI / IAP is a hydrolase enzyme responsible for removing phosphate groups from many types of molecules, including nucleotides, proteins, and alkaloids. Lysophosphatidylcholine (LysoPC) releases IAP into the apical medium more than other intestinal brush-border enzymes, sucrose, aminopeptidase N, and lactase, without comparable lactate dehydrogenase release or cell injury. There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver / bone / kidney (tissue non-specific). Intestinal ALP shows 86.5% amino acid identity to placental ALP and 56.6% amino acid identity to liver / bone / kidney ALP.

Alkaline Phosphatase, Intestinal (ALPI, IAP) Related Areas

Enzyme>>Protease & Regulator>>Metalloprotease & Regulator>> ALPI / IAP

Enzyme>>Lipid Metabolism Enzymes>> ALPI / IAP

Cardiovascular>>Lipid Metabolism>>Lipid Metabolism Enzymes>> ALPI / IAP

Enzyme>>Other>> ALPI / IAP

Alkaline Phosphatase, Intestinal (ALPI, IAP) Alternative Names

Kasahara isozyme; alkaline phosphomonoesterase; glycerophosphatase; intestinal alkaline phosphatase; intestinal-type alkaline phosphatase [Homo sapiens]

Summaries for Alkaline Phosphatase, Intestinal (ALPI, IAP)

Entrez Gene summary for Alkaline Phosphatase, Intestinal (ALPI, IAP):

There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The intestinal alkaline phosphatase gene encodes a digestive brush-border enzyme. This enzyme is upregulated during small intestinal epithelial cell differentiation. [provided by RefSeq, Jul 2008]

Wikipedia summary for Alkaline Phosphatase, Intestinal (ALPI, IAP):

Alkaline phosphatase, intestinal also known as ALPI is a type of alkaline phosphatase that in humans is encoded by the ALPI gene.

Human Alkaline Phosphatase, Intestinal (ALPI, IAP) Protein General Information

 

• Protein names: Intestinal-type alkaline phosphatase
  Short name=IAP
• Sequence length: 528 AA.
• Domain: Signal
  Transmembrane
• Sequence similarities: Belongs to the alkaline phosphatase family.
• Cofactor: Binds 1 magnesium ion .
  Binds 2 zinc ions .
• Subunit structure: Homodimer.
• Subcellular location: Cell membrane; Lipid-anchor › GPI-anchor.
• Catalytic activity: A phosphate monoester + H₂O = an alcohol + phosphate.
• Miscellaneous: In most mammals there are four different isozymes: placental, placental-like, intestinal and tissue non-specific (liver/bone/kidney).

General information above from UniProt

Function for Alkaline Phosphatase, Intestinal (ALPI, IAP) Protein

Genatlas:

• unknown