Adipsin (Complement Factor D)

Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classical pathway.

Adipsin (Complement Factor D) Related Areas

Enzyme>>Protease & Regulator>>Serine Protease & Regulator>>Complement System>>Adipsin/Complement Factor D

Immunology>>Innate Immunity>>Complement System>>Adipsin/Complement Factor D

Adipsin (Complement Factor D) Alternative Names

Adipsin, Complement Factor D, CFD, ADN, DF, PFD [Homo sapiens]

Adipsin, Complement Factor D, Cfd, Adn, DF [Mus musculus]

Summaries for Adipsin (Complement Factor D)

Entrez Gene summary for Adipsin (Complement Factor D):

The protein encoded by this gene is a member of the trypsin family of peptidases. The encoded protein is a component of the alternative complement pathway best known for its role in humoral suppression of infectious agents. This protein is also a serine protease that is secreted by adipocytes into the bloodstream. Finally, the encoded protein has a high level of expression in fat, suggesting a role for adipose tissue in immune system biology.

OMIM - description for Adipsin (Complement Factor D):

The CFD gene encodes complement factor D, a serine protease that acts in the alternative complement pathway to complete the formation of the C3 convertase enzyme by cleaving factor B (CFB; 138470) bound to C3b (120700), yielding C3bBb. Factor D is the initial obligatory and rate-limiting catalytic component in the alternative complement pathway

Wikipedia summary for Adipsin (Complement Factor D):

Factor D also known as complement factor D(CFD) or adipsin a protein which in humans is encoded by the CFD gene.[2] Factor D is involved in the alternative complement pathway of the complement system where it cleaves factor B

Human Adipsin (Complement Factor D) Protein General Information

 

• Protein names: Recommended name: Complement factor D
• Sequence length: 253 AA.
• Domain: Signal
• Sequence similarities: Belongs to the peptidase S1 family. Contains 1 peptidase S1 domain.
• Catalytic activity: Selective cleavage of Arg-|-Lys bond in complement factor B when in complex with complement subcomponent C3b or with cobra venom factor.
• Sequence caution: The sequence AAA35527.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
• Subcellular location: Secreted.
• Involvement in disease: Defects in CFD are the cause of complement factor D deficiency (CFDD) [MIM:613912]. CFDD is an immunologic disorder characterized by increased susceptibility to bacterial infections, particularly Neisseria infections, due to a defect in the alternative complement pathway.

General information above from UniProt

Function for Adipsin (Complement Factor D) Protein

UniProtKB:

Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classical pathway.

Genatlas:

• Adipsin (Complement Factor D) serine protease that is secreted by adipocytes into the bloodstream
• Adipsin (Complement Factor D) is cleaving complement factor B from activated C3 (C3bbb)

Phenotype Information for Adipsin (Complement Factor D)

• Gene/Locus: CFD, ADN
• Phenotype: Complement factor D deficiency

Phenotype Information for Adipsin (Complement Factor D) from OMIM (Online Mendelian Inheritance in Man)

Drugs for Adipsin (Complement Factor D)

Target	Drug Name	Disease	Drug Status
Adipsin (Complement Factor D)	Anti-Factor D	Geographic atrophy associated with age-related macular degeneration	Phase I/II

Drugs for Adipsin (Complement Factor D) from TTD (Therapeutic Targets Database)