Anti-Factor D Antibody (Rabbit Monoclonal antibody) General Information
Anti-Factor D Antibody
Reacts with: Human
Human Factor D
Recombinant Human Adipsin / Complement Factor D protein (Catalog#10160-H08H)
This antibody was obtained from a rabbit immunized with purified, recombinant Human Adipsin / Complement Factor D (rh Adipsin / Complement Factor D; Catalog#10160-H08H; P00746; Ile26-Ala253).
Monoclonal Rabbit IgG Clone #005
0.2 μm filtered solution in PBS
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-Factor D Antibody (Rabbit Monoclonal antibody) Validated Applications
**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********
Anti-Factor D Antibody Alternative Names
Anti-ADIPSIN Antibody;Anti-ADN Antibody;Anti-DF Antibody;Anti-FACTOR D Antibody;Anti-PFD Antibody
Factor D Background Information
Complement factor D, also known as Adipsin, C3 convertase activator, Properdin factor D and CFD is a secreted protein which belongs to the peptidase S1 family. CFD / Adipsin contains one peptidase S1 domain. Complement factor D ( CFD / Adipsin ) is a component of the alternative complement pathway best known for its role in humoral suppression of infectious agents. Complement factor D ( CFD / Adipsin ) has a high level of expression in fat, suggesting a role for adipose tissue in immune system biology. This protein is also a serine protease that is secreted by adipocytes into the bloodstream. Complement factor D ( CFD / Adipsin ) cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classical pathway. Complement factor D ( CFD / Adipsin ) is a serine protease that stimulates glucose transport for triglyceride accumulation in fats cells and inhibits lipolysis. Defects in CFD / Adipsin are the cause of complement factor D deficiency (CFD deficiency) which predisposes to invasive meningococcal disease.
complement factor D (adipsin)
Volanakis JE, et al.,1996, Protein Sci. 5 (4): 553-64. Searfoss,G.H et al., 2003, J Biol Chem. 278 (46):46107-16. Ukkola,O. et al., 2003, Eur J Clin Nutr. 57 (9):1073-8. Ronti T, et al., 2006, Clin. Endocrinol. (Oxf) 64 (4): 355-65.