Adenylate kinase 1 (AK1)

Adenylate kinase 1 (AK1) belongs to the Adenylate kinase family that contains three isozymes: AK1, AK2 and AK3. Adenylate kinases are involved in regulating the adenine nucleotide composition within a cell by catalyzing the reversible transfer of phosphate groups among adenine nucleotides. AK1 / ADK has functions in delivering AMP signals to metabolic sensors. It facilitates decoding of cellular information by catalyzing nucleotide exchange in the intimate "sensing zone" of metabolic sensors. With presence of ADK / AK1 in mitochondrial and myofibrillar compartments, the energy of two high-energy phosphoryls, ?- and ?- phosphoryls in the ATP molecule is available. ADK / AK1 can read the cellular energy state, communicates AMP signals to metabolic sensors. This kinase is able to convey information about the overall energy balance. ADK / AK1 is related with several diseases, including nucleoside diphosphate kinase deficiency, hemolytic anemia, AK1 and post-ischemic coronary reflow and ADK2 deficiency.

Adenylate kinase 1 (AK1) Related Areas

Enzyme>>Phosphatase & Regulator>> AK1

Signal Transduction>>Phosphatase & Regulator>> AK1

Adenylate kinase 1 (AK1) Alternative Names

RP11-203J24.1[Homo sapiens]

RP23-17P12.3, Ak-1, B430205N08Rik[Mus musculus]

Summaries for Adenylate kinase 1 (AK1)

Entrez Gene summary for Adenylate kinase 1 (AK1):

Adenylate kinase is an enzyme involved in regulating the adenine nucleotide composition within a cell by catalyzing the reversible transfer of phosphate group among adinine nucleotides. Three isozymes of adenylate kinase have been identified in vertebrates, adenylate isozyme 1 (AK1), 2 (AK2) and 3 (AK3). AK1 is found in the cytosol of skeletal muscle, brain and erythrocytes, whereas AK2 and AK3 are found in the mitochondria of other tissues including liver and heart. AK1 was identified because of its association with a rare genetic disorder causing nonspherocytic hemolytic anemia where a mutation in the AK1 gene was found to reduce the catalytic activity of the enzyme.

OMIM - description for Adenylate kinase 1 (AK1):

Adenylate kinase (EC 2.7.4.3) is a ubiquitous monomeric enzyme that catalyzes the reversible conversion of MgATP plus AMP to MgADP plus ADP and contributes to homeostasis of the adenine nucleotide composition in the cell

Wikipedia summary for Adenylate kinase 1 (AK1):

Human Adenylate kinase 1 (AK1) Protein General Information

 

• Protein names: Recommended name: Adenylate kinase 1 Short name=AK 1
• Sequence length: 222 AA.
• Sequence similarities: Belongs to the adenylate kinase family. AK2 subfamily.
• Miscellaneous: Present with 123000 molecules/cell in log phase SD medium
• Subunit structure: Monomer.
• Subcellular location: Cytoplasm › cytosol. Mitochondrion intermembrane space
• Catalytic activity: ATP + AMP = 2 ADP.

General information above from UniProt

Function for Adenylate kinase 1 (AK1) Protein

UniProtKB:

Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Small ubiquitous enzyme involved in energy metabolism and nucleotide synthesis that is essential for maintenance and cell growth. Functions both in the cytoplasm and mitochondrion intermembrane space.