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Adaptor Protein

Adaptor proteins mostly function as flexible molecular scaffolds that mediate protein–protein and protein–lipid interactions in signal transduction pathways. Adaptor proteins usually contain several domains within their structure which allow specific interactions with several other specific proteins, and are positioned to regulate cell signaling in a spatial and temporal fashion. By this means, adaptor proteins can amplify a receptor-mediated signal and facilitate coupling of the signal to different signal transduction pathways.

Sino Biological offers a comprehensive set of products that directed towards molecules that act as adaptor proteins in signaling pathways. These high quality research tools include recombinant proteins, antibodies (rabbit MAbs, mouse MAbs, rabbit PAbs), ELISA kits, and gene cDNA clones.

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    Adaptor Protein Background

    Adaptor proteins mostly function as flexible molecular scaffolds that mediate protein–protein and protein–lipid interactions in signal transduction pathways. Specificity in signaling would be achieved by the type of protein binding modules encoded by the adaptor protein, the sequence of these domains or motifs that would dictate specificity in binding, as well as the subcellular localization and the proximity of binding partners. Thus, adaptor proteins are positioned to regulate cell signaling in a spatial and temporal fashion. Adaptor proteins usually contain several domains within their structure which allow specific interactions with several other specific proteins. For example, SH2 domains recognize specific amino acid sequences within proteins containing phosphotyrosine residues and SH3 domains recognize proline-rich sequences within specific peptide sequence contexts of proteins. Lipid-interaction modules like the PH (pleckstrin homology) or PX (phox homology) domains bind phosphatidylinositides and determine the localization of the adaptor protein. By this means adaptor proteins can amplify a receptor-mediated signal and facilitate coupling of the signal to different signal transduction pathways.

    Adaptor Protein References

      1. Daniel C Flynn (2001) Adaptor proteins. Oncogene 20:6270-6272.
      2. Najib S, et al. (2005) Role of Sam68 as an adaptor protein in signal transduction. Cell Mol Life Sci. 62(1):36-43.
      3. Park SK, et al. (2009) Src-like adaptor protein (SLAP) is upregulated in antigen-stimulated mast cells and acts as a negative regulator. Mol Immunol. 46(10):2133-9.
      4. Román-Hernández G, et al. (2009) Molecular basis of substrate selection by the N-end rule adaptor protein ClpS. Proc Natl Acad Sci U S A. 106(22):8888-93.