Acute Lymphoblastic Leukemia Therapeutic Targets

Protein Name	Alternative Names	BioChemical Class / Role	Products (Cat NO)
			Protein	Antibody	Gene cDNA clones
FLT-3/CD135/FLK-2	RP11-153M24.3, STK1	FL cytokine receptor, also known as tyrosine-protein kinase receptor FLT3, Stem cell tyrosine kinase 1, STK-1, FLT3 and CD135, is a single-pass type I membrane protein. Signaling through CD135 plays a role in cell survival, proliferation, and differentiation. CD135 is also important for lymphocyte (B cell and T cell) development, but not for the development of other blood cells (myeloid development). Identified as a proto-oncogene, the mutations of FLTS gene are associated with certain carcinomas.	10445-H08H		HG10445-M
CDK2	p33(CDK2)	CDK2 (cyclin-dependent kinase 2), is a member of the cyclin-dependent kinase family（CDK）of Ser/Thr protein kinases. Some researchers demonstrated an unpredicted participation of CDK2 in the accurate pairing and recombination between homologues during mammalian meiosis. CDK2 was thought to be a crucial regulator of S-phase progression and was evaluated as an anticancer drug target.	10624-H08B		HG10624-M