Acetylcholinesterase Protein & Antibody (ACHE)

Acetylcholinesterase Products

Acetylcholinesterase Protein, Recombinant

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
Acetylcholinesterase/ACHE	Mouse	Acetylcholinesterase/ACHE Protein, Recombinant	50543-M08H

Acetylcholinesterase Antibody

Molecule	Application	Description //For Detailed Info. and Price------CLICK!	Cat. No
Mouse Acetylcholinesterase/ACHE	WB, ELISA	Acetylcholinesterase / ACHE Antibody	50543-RP01
Mouse Acetylcholinesterase/ACHE	WB, ELISA	Acetylcholinesterase / ACHE Antibody (Antigen Affinity Purified)	50543-RP02

Acetylcholinesterase cDNA Clone

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
Acetylcholinesterase/ACHE	Mouse	Mus musculus Acetylcholinesterase/ACHE cDNA Clone	MG50543-M

Acetylcholinesterase Related Areas

Enzyme>>Other>>Acetylcholinesterase/ACHE

Acetylcholinesterase Alternative Names

Acetylcholinesterase, ACHE, ARACHE, N-ACHE, YT [Homo sapiens]

Acetylcholinesterase, Ache, mE1a, mE1b, mE1c, mE1c-long, mE1d, mE1d', mE1e [Mus musculus]

Acetylcholinesteras Background

Acetylcholinesterase, also known as ACHE, is an enzyme that degrades (through its hydrolytic activity) the neurotransmitter acetylcholine, producing choline and an acetate group. Acetylcholinesterase plays a crucial role in nerve impulse transmission at cholinergic synapses by rapid hydrolysis of the neurotransmitter acetylcholine (ACh). ACHE appears to be a potential therapeutic target at muscle injuries including organophosphate myopathy. It is an externally oriented membrane-bound enzyme and its main physiological role is termination of chemical transmission at cholinergic synapses and secretory organs by rapid hydrolysis of the neurotransmitter acetylcholine (ACh). Nevertheless, it is well known that cyclophosphamide (CP; nitrogen mustard derivative) is an eminent anticancer drug. ACHE plays important roles in the cholinergic system, and its dysregulation is involved in a variety of human diseases. ACHE was significantly down-regulated in the cancerous tissues of 69.2% of hepatocellular carcinoma (HCC) patients, and the low ACHE expression in HCC was correlated with tumor aggressiveness, an elevated risk of postoperative recurrence, and a low survival rate. Both the recombinant ACHE protein and the enhanced expression of ACHE significantly inhibited HCC cell growth in vitro and tumorigenicity in vivo. ACHE as a tumor growth suppressor in regulating cell proliferation, the relevant signaling pathways, and the drug sensitivity of HCC cells. Thus, ACHE is a promising independent prognostic predictor for HCC recurrence and the survival of HCC patients. ACHE is responsible for the hydrolysis of acetylcholine in the nervous system. It is inhibited by organophosphate and carbamate pesticides. However, this enzyme is only slightly inhibited by organophosphorothionates.

Acetylcholinesteras Related Studies

1. Zhao Y, et al. (2011) Acetylcholinesterase, a key prognostic predictor for hepatocellular carcinoma, suppresses cell growth and induces chemosensitization. Hepatology. 53(2): 493-503.
2. Kamal MA, et al. (2010) Multiple approaches to analyse the data for rat brain acetylcholinesterase inhibition by cyclophosphamide. Neurochem Res. 35(10): 1501-9.
3. Roepcke CB, et al. (2010) Analysis of phosphorothionate pesticides using a chloroperoxidase pretreatment and acetylcholinesterase biosensor detection. J Agric Food Chem. 58(15): 8748-56.
4. Zaheer-ul-Haq, et al. (2010) Benchmarking docking and scoring protocol for the identification of potential acetylcholinesterase inhibitors. J Mol Graph Model. 28(8): 870-82.
5. Pegan K, et al. (2010) Acetylcholinesterase is involved in apoptosis in the precursors of human muscle regeneration. Chem Biol Interact. 187(1-3): 96-100.