Acetoacetyl-CoA Synthetase Protein & Antibody (AACS)

Acetoacetyl-CoA Synthetase Products

Acetoacetyl-CoA Synthetase Protein, Recombinant

Molecule	Species	Description	Cat. No
Acetoacetyl-CoA Synthetase/AACS	Human	Acetoacetyl-CoA Synthetase/AACS Protein, Recombinant	11117-H07B

Acetoacetyl-CoA Synthetase Antibody

Molecule	Application	Description	Cat. No
Human Acetoacetyl-CoA Synthetase/AACS	WB, ELISA	Acetoacetyl-CoA Synthetase/AACS Antibody, Mouse Mab	11117-MM03

Acetoacetyl-CoA Synthetase cDNA Clone

Molecule	Species	Description	Cat. No
Acetoacetyl-CoA Synthetase/AACS	Human	Homo sapiens Acetoacetyl-CoA Synthetase/AACS cDNA Clone	HG11117-M

Acetoacetyl-CoA Synthetase Related Areas

Enzyme>>Lipid Metabolism Enzymes>>Acetoacetyl-CoA Synthetase/AACS

Cardiovascular>>Lipid Metabolism>>Lipid Metabolism Enzymes>>Acetoacetyl-CoA Synthetase/AACS

Acetoacetyl-CoA Synthetase Alternative Names

Acetoacetyl-CoA Synthetase, AACS, ACSF1, FLJ12389, FLJ41251, SUR-5 [Homo sapiens]

Acetoacetyl-CoA Synthetase, Aacs, 2210408B16Rik, SUR5 [Mus musculus]

Acetoacetyl-CoA Synthetase Background

Acetoacetyl-CoA Synthetase (AACS) is a novel cytosolic ketone body (acetoacetate)-specific ligase. The AACS in adipose tissue plays an important role in utilizing ketone body for the fatty acid-synthesis during adipose tissue development. It had been improved that Acetoacetyl-CoA Synthetase is an essential enzyme for the synthesis of fatty acid and cholesterol from ketone bodies, was found to be highly expressed in mouse adipose tissue, and GC box and C/EBPs motif were crucial for AACS promoter activity in 3T3-L1 adipocytes. Moreover, AACS promoter activity was controlled mainly by C/EBPalpha during adipogenesis. AACS gene expression is particularly abundant in white adipose tissue, as it is induced during adipocyte differentiation. The human AACS promoter is a PPARgamma target gene and that this nuclear receptor is recruited to the AACS promoter by direct interaction with Sp1 (stimulating protein-1). The Acetoacetyl-CoA Synthetase has important roles in the regulation of ketone body utilization in rat liver and that these hypocholesterolemic agents have the ability to remedy the impaired utilization of ketone bodies under the diabetic condition.

Acetoacetyl-CoA Synthetase Related Studies

1. Aguiló F, et al. (2010) Transcriptional regulation of the human acetoacetyl-CoA synthetase gene by PPARgamma. Biochem J. 427(2): 255-64.
2. Hasegawa S, et al. (2008) Transcriptional regulation of ketone body-utilizing enzyme, acetoacetyl-CoA synthetase, by C/EBPalpha during adipocyte differentiation. Biochim Biophys Acta. 1779(6-7): 414-9.
3. Sato H, et al. (2002) Effects of streptozotocin-induced diabetes on acetoacetyl-CoA synthetase activity in rats. Biochem Pharmacol. 63(10): 1851-5.