Anti-AXL Antibody

Cat: 10279-RP01
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Anti-AXL Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-AXL Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Human
Specificity
Human AXL
Immunogen
Recombinant Human AXL protein (Catalog#10279-H08H)
Preparation
Produced in rabbits immunized with purified, recombinant Human AXL (rh AXL; Catalog#10279-H08H; NP_068713.2; Met 1-Pro 449). Total IgG was purified by Protein A affinity chromatography .
Source
Polyclonal Rabbit IgG
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-AXL Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:1000-1:2000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-AXL Antibody Alternative Names
Anti-ARK Antibody;Anti-JTK11 Antibody;Anti-Tyro7 Antibody;Anti-UFO Antibody
AXL Background Information

Axl receptor tyrosine kinase, together with Tyro3 and Mer, constitute the TAM family of receptor tyrosine kinases. In the nervous system, Axl and its ligand Growth-arrest-specific protein 6 (Gas6) are expressed on multiple cell types. Axl functions in dampening the immune response, regulating cytokine secretion, clearing apoptotic cells and debris, and maintaining cell survival. Axl is upregulated in various disease states, such as in the cuprizone toxicity-induced model of demyelination and in multiple sclerosis (MS) lesions, suggesting that it plays a role in disease pathogenesis. Axl expression correlates with poor prognosis in several cancers. Axl mediates multiple oncogenic phenotypes and activation of these RTKs constitutes a mechanism of chemoresistance in a variety of solid tumors. Axl contributes to cell survival, migration, invasion, metastasis and chemosensitivity justify further investigation of Axl as novel therapeutic targets in cancer. The receptor tyrosine kinase AXL is thought to play a role in metastasis. The soluble AXL receptor as a therapeutic candidate agent for treatment of metastatic ovarian cancer. GAS6/AXL targeting as an effective strategy for inhibition of metastatic tumor progression in vivo.

Full Name
AXL receptor tyrosine kinase
References
  • Weinger JG, et al. (2011) Loss of the receptor tyrosine kinase Axl leads to enhanced inflammation in the CNS and delayed removal of myelin debris during Experimental Autoimmune Encephalomyelitis. J Neuroinflammation. 8: 49.
  • Linger RM, et al. (2010) Taking aim at Mer and Axl receptor tyrosine kinases as novel therapeutic targets in solid tumors. Expert Opin Ther Targets. 14(10): 1073-90.
  • Cavet ME, et al. (2010) Gas6-Axl pathway: the role of redox-dependent association of Axl with nonmuscle myosin IIB. Hypertension. 56(1): 105-11.
  • Rankin EB, et al. (2010) AXL is an essential factor and therapeutic target for metastatic ovarian cancer. Cancer Res. 70(19): 7570-9.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-AXL Antibody Rabbit Monoclonal ELISA,ELISA(Det) 50126-R015
    Anti-AXL Antibody Rabbit Polyclonal ELISA 50126-RP02
    Anti-AXL Antibody Rabbit Polyclonal ELISA 50126-T16
    Anti-AXL Antibody Rabbit Monoclonal ELISA,ELISA(Cap) 50126-R109
    Anti-AXL Antibody Rabbit Polyclonal ELISA 50126-RP01
    Anti-AXL Antibody Rabbit Polyclonal ELISA 10279-RP02
    Anti-AXL Antibody Rabbit Monoclonal ELISA 10279-R003
    Anti-AXL Antibody Rabbit Monoclonal FCM 10279-R101
    Anti-AXL Antibody Rabbit Polyclonal ELISA 10279-T16
    Anti-AXL Antibody Mouse Monoclonal ELISA 10279-MM17
    Anti-AXL Antibody (FITC) Rabbit Monoclonal FCM 10279-R101-F
    Anti-AXL Antibody Mouse Monoclonal ELISA 10279-MM05
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